KEGG   DISEASE: Ulcerative colitis
Entry
H01466                      Disease                                
Name
Ulcerative colitis
  Supergrp
Inflammatory bowel disease (IBD) [DS:H01227]
Description
Ulcerative colitis (UC) is one subtype of inflammatory bowel disease (IBD) whose pathogenesis is multifactorial and includes influences from genes, the environment, and the gut microbiome. In UC the inflammatory is limited to the mucosa of the colon and rectum. Clinically, the most common manifestation of UC may include bloody diarrhea, abdominal pain. In most severe cases, patients may experience fever, weight loss, anemia, and the intestine can get distended, presenting deep ulceration and possibly intestinal perforation.The long-time duration of the disease increases a colorectal cancer risk. UC is associated with a Th2 immune response. Recent genetic analyses have linked genes including interleukin 23 receptor, interleukin 10 and macrophage stimulating 1.
Category
Immune system disease
Brite
Human diseases [BR:br08402]
 Immune system diseases
  Other immune system diseases
   H01466  Ulcerative colitis
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Inflammatory bowel diseases
   DD71  Ulcerative colitis
    H01466  Ulcerative colitis
Pathway
hsa05321  Inflammatory bowel disease
Related
pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway
Gene
IL23R [HSA:149233] [KO:K05065]
IL10 [HSA:3586] [KO:K05443]
IL37 [HSA:27178] [KO:K05485]
MST1 [HSA:4485] [KO:K23441]
Pathogen
Fusobacterium varium [GN:fva]
Drug
Triamcinolone acetonide [DR:D00983]
Dexamethasone [DR:D00292]
Dexamethasone sodium phosphate [DR:D00975]
Hydrocortisone [DR:D00088]
Hydrocortisone acetate [DR:D00165]
Hydrocortisone sodium succinate [DR:D00978]
Prednisolone [DR:D00472]
Prednisolone sodium phosphate [DR:D00981]
Prednisone [DR:D00473]
Budesonide [DR:D00246]
Sulfasalazine [DR:D00448]
Mesalamine [DR:D00377]
Olsalazine sodium [DR:D00727]
Balsalazide disodium [DR:D02715]
Methylprednisolone [DR:D00407]
Methylprednisolone sodium succinate [DR:D00751]
Methylprednisolone acetate [DR:D00979]
Cortisone acetate [DR:D00973]
Tofacitinib citrate [DR:D09783]
Vedolizumab [DR:D08083]
Upadacitinib hydrate [DR:D11048]
Infliximab [DR:D02598]
Adalimumab [DR:D02597]
Golimumab [DR:D04358]
Ustekinumab [DR:D09214]
Other DBs
ICD-11: DD71
ICD-10: K51
MeSH: D003093
OMIM: 612261 619398
Reference
  Authors
de Mattos BR, Garcia MP, Nogueira JB, Paiatto LN, Albuquerque CG, Souza CL, Fernandes LG, Tamashiro WM, Simioni PU
  Title
Inflammatory Bowel Disease: An Overview of Immune Mechanisms and Biological Treatments.
  Journal
Mediators Inflamm 2015:493012 (2015)
DOI:10.1155/2015/493012
Reference
  Authors
Abraham C, Cho JH
  Title
Inflammatory bowel disease.
  Journal
N Engl J Med 361:2066-78 (2009)
DOI:10.1056/NEJMra0804647
Reference
PMID:17068223 (IL23R)
  Authors
Duerr RH, Taylor KD, Brant SR, Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, Abraham C, Regueiro M, Griffiths A, Dassopoulos T, Bitton A, Yang H, Targan S, Datta LW, Kistner EO, Schumm LP, Lee AT, Gregersen PK, Barmada MM, Rotter JI, Nicolae DL, Cho JH
  Title
A genome-wide association study identifies IL23R as an inflammatory bowel disease gene.
  Journal
Science 314:1461-3 (2006)
DOI:10.1126/science.1135245
Reference
PMID:18836448 (IL10)
  Authors
Franke A, Balschun T, Karlsen TH, Sventoraityte J, Nikolaus S, Mayr G, Domingues FS, Albrecht M, Nothnagel M, Ellinghaus D, Sina C, Onnie CM, Weersma RK, Stokkers PC, Wijmenga C, Gazouli M, Strachan D, McArdle WL, Vermeire S, Rutgeerts P, Rosenstiel P, Krawczak M, Vatn MH, Mathew CG, Schreiber S
  Title
Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility.
  Journal
Nat Genet 40:1319-23 (2008)
DOI:10.1038/ng.221
Reference
PMID:33674380 (IL37)
  Authors
Zhang ZZ, Zhang Y, He T, Sweeney CL, Baris S, Karakoc-Aydiner E, Yao Y, Ertem D, Matthews HF, Gonzaga-Jauregui C, Malech HL, Su HC, Ozen A, Smith KGC, Lenardo MJ
  Title
Homozygous IL37 mutation associated with infantile inflammatory bowel disease.
  Journal
Proc Natl Acad Sci U S A 118:e2009217118 (2021)
DOI:10.1073/pnas.2009217118
Reference
PMID:22237417 (MST1)
  Authors
Hauser F, Deyle C, Berard D, Neukirch C, Glowacki C, Bickmann JK, Wenzel JJ, Lackner KJ, Rossmann H
  Title
Macrophage-stimulating protein polymorphism rs3197999 is associated with a gain of function: implications for inflammatory bowel disease.
  Journal
Genes Immun 13:321-7 (2012)
DOI:10.1038/gene.2011.88
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