KEGG   DRUG: ClonazepamHelp
Entry
D00280                      Drug                                   

Name
Clonazepam (JP17/USP/INN);
Clonazepam fine granules (JP17);
Clonazepam tablets (JP17);
Klonopin (TN)
Product
  Generic
CLONAZEPAM (A-S Medication Solutions), CLONAZEPAM (ATLANTIC BIOLOGICALS CORP.), CLONAZEPAM (ATLANTIC BIOLOGICALS CORP.), CLONAZEPAM (Accord Healthcare), CLONAZEPAM (Actavis Pharma), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aidarex Pharmaceuticals LLC), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Aphena Pharma Solutions - Tennessee), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Bryant Ranch Prepack), CLONAZEPAM (Caraco Pharmaceutical Laboratories), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Cardinal Health), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (Contract Pharmacy Services-PA), CLONAZEPAM (DIRECT RX), CLONAZEPAM (DIRECT RX), CLONAZEPAM (Direct Rx), CLONAZEPAM (Dispensing Solutions), CLONAZEPAM (Eon Labs), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (Golden State Medical Supply), CLONAZEPAM (H.J. Harkins Company), CLONAZEPAM (KAISER FOUNDATION HOSPITALS), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), CLONAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), CLONAZEPAM (Major Pharmaceuticals), CLONAZEPAM (McKesson Corporation), CLONAZEPAM (Medsource Pharmaceuticals), CLONAZEPAM (Mylan Institutional), CLONAZEPAM (Mylan Pharmaceuticals), CLONAZEPAM (NCS HealthCare of KY), CLONAZEPAM (NCS HealthCare of KY), CLONAZEPAM (NCS HealthCare of KY), CLONAZEPAM (Northstar RxLLC), CLONAZEPAM (Northwind Pharmaceuticals), CLONAZEPAM (Nu Care Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (NuCare Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (PD-Rx Pharmaceuticals), CLONAZEPAM (Par Pharmaceutical), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Preferred Pharmaceuticals), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Proficient Rx LP), CLONAZEPAM (Qualitest Pharmaceuticals), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (REMEDYREPACK), CLONAZEPAM (RPK Pharmaceuticals), CLONAZEPAM (Rebel Distributors), CLONAZEPAM (Sandoz), CLONAZEPAM (Solco Healthcare LLC), CLONAZEPAM (St Marys Medical Park Pharmacy), CLONAZEPAM (Sun Pharmaceutical Industries), CLONAZEPAM (TYA Pharmaceuticals), CLONAZEPAM (TYA Pharmaceuticals), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (Teva Pharmaceuticals USA), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services), CLONAZEPAM (Unit Dose Services)
Formula
C15H10ClN3O3
Exact mass
315.0411
Mol weight
315.7112
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG02036  Antiepileptics, benzodiazepine derivatives
Remark
Therapeutic category: 1139
ATC code: N03AE01
Product: D00280<JP/US>
Efficacy
Anticonvulsant, Antiepileptic
  Disease
Lennox-Gastaut syndrome [DS:H01813]
Panic disorder [DS:H01664]
Comment
Benzodiazepine derivative
Cytochrome P-450 including CYP3A, may play an important role in clonazepam reduction and oxidation.
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AE Benzodiazepine derivatives
     N03AE01 Clonazepam
      D00280  Clonazepam (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Clonazepam
    D00280  Clonazepam (JP17/USP/INN)
 Anxiolytics
  Benzodiazepines
   Clonazepam
    D00280  Clonazepam (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00280  Clonazepam (JP17/USP/INN); Clonazepam fine granules (JP17); Clonazepam tablets (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00280  Clonazepam (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00280  Clonazepam
  D00280  Clonazepam tablets
  D00280  Clonazepam fine granules
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00280
BRITE hierarchy
Other DBs
CAS: 1622-61-3
PubChem: 7847346
ChEBI: 3756
ChEMBL: CHEMBL452
DrugBank: DB01068
LigandBox: D00280
NIKKAJI: J5.233G
LinkDB All DBs
KCF data Show

ATOM        22
            1   C2y C    18.3334  -14.2894
            2   C8y C    17.4913  -13.1798
            3   C8y C    17.8265  -11.8230
            4   N1x N    19.0875  -11.2449
            5   N2x N    19.7392  -14.3146
            6   C5x C    20.3411  -11.8672
            7   C1x C    20.6276  -13.2359
            8   C8x C    16.8194  -10.8546
            9   C8x C    15.4774  -11.2427
            10  C8y C    15.1422  -12.5995
            11  C8x C    16.1493  -13.5676
            12  N2b N    13.7774  -12.9939 #+
            13  C8y C    17.6989  -15.5391
            14  C8x C    16.2973  -15.5391
            15  O5x O    21.4503  -11.0095
            16  C8x C    15.5973  -16.7516
            17  C8x C    16.2973  -17.9640
            18  C8x C    17.6989  -17.9640
            19  C8y C    18.3989  -16.7516
            20  X   Cl   19.8098  -16.7517
            21  O3a O    12.6477  -11.9025 #-
            22  O3a O    13.4361  -14.3745
BOND        24
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16    6  15 2
            17   14  16 2
            18   16  17 1
            19   17  18 2
            20   18  19 1
            21   13  19 2
            22   19  20 1
            23   12  21 1
            24   12  22 2

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