KEGG   DRUG: CosyntropinHelp
Entry
D00284                      Drug                                   

Name
Cosyntropin (USAN);
Tetracosactide (INN);
Cortrosyn (TN)
Product
  Generic
Formula
C136H210N40O31S
Exact mass
2931.5806
Mol weight
2933.437
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Sequence
Ser Tyr Ser Met Glu His Phe Arg Trp Gly Lys Pro Val Gly Lys Lys
Arg Arg Pro Val Lys Val Tyr Pro
  Type
Peptide
Class
Other
 DG01629  Adrenocorticotropic hormone (ACTH)
Remark
Same as: C06926
ATC code: H01AA02
Chemical structure group: DG00493
Product (DG00493): D00284<US> D02105<JP>
Efficacy
Diagnostic (adrenocortical function), Melanocortin receptor agonist
Comment
syntheses drenocorticotropic hormone (ACTH)
Target
MC2R [HSA:4158] [KO:K04200]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04925  Aldosterone synthesis and secretion
hsa04927  Cortisol synthesis and secretion
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AA ACTH
     H01AA02 Tetracosactide
      D00284  Cosyntropin (USAN) <US>
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Melanocortin
    MC2R
     D00284  Cosyntropin (USAN) <US>
Drug classes of therapeutic agents [br08360.html]
 Endocrine and hormonal agents
  D00284
BRITE hierarchy
Other DBs
CAS: 16960-16-0
PubChem: 7847350
ChEBI: 3901
DrugBank: DB01284
NIKKAJI: J9.064F
LinkDB All DBs
KCF data Show

ATOM        208
            1   C8y C    31.4015  -47.5464
            2   C8y C    30.9959  -46.2317
            3   C8y C    32.7545  -47.5464
            4   C8x C    30.7014  -48.7173
            5   C1b C    29.4651  -46.2317
            6   C8x C    32.1072  -45.4080
            7   N4x N    33.2126  -46.2317
            8   C8x C    33.4417  -48.7500
            9   C8x C    31.3816  -49.9666
            10  C1c C    28.2290  -45.5974
            11  C8x C    32.7417  -49.9666
            12  N1b N    28.2290  -44.2243
            13  C5a C    27.0978  -46.4083
            14  C5a C    29.3168  -43.4460
            15  N1b N    27.1106  -47.8211
            16  O5a O    25.8814  -45.7609
            17  C1c C    29.3472  -42.0660
            18  O5a O    30.5835  -44.0538
            19  C1b C    25.9737  -48.5793
            20  N1b N    30.4351  -41.2480
            21  C1b C    28.1308  -41.4188
            22  C5a C    24.6674  -47.9062
            23  C5a C    30.4597  -39.8552
            24  C1b C    28.1308  -40.0188
            25  N1b N    24.6392  -46.5193
            26  O5a O    23.6448  -48.7956
            27  C1c C    31.6434  -39.0968
            28  O5a O    29.2630  -39.2535
            29  C1b C    26.9085  -39.3714
            30  C1c C    23.4484  -45.8719
            31  N1b N    31.5978  -37.7041
            32  C1b C    32.8398  -39.7243
            33  N1b N    26.8758  -37.9786
            34  C5a C    23.4228  -44.4662
            35  C1b C    22.2845  -46.6374
            36  C5a C    32.7545  -36.9187
            37  C8y C    32.8225  -41.1371
            38  C2c C    25.6791  -37.3639
            39  N1y N    22.2320  -43.8190
            40  O5a O    24.6193  -43.7007
            41  C1b C    21.0740  -46.0355
            42  C1c C    32.7358  -35.4802
            43  O5a O    33.9711  -37.5602
            44  C8x C    31.7017  -41.8896
            45  C8x C    34.0890  -41.7587
            46  N1a N    25.6896  -35.9511
            47  N2a N    24.5014  -38.1294
            48  C1y C    22.0556  -42.4390
            49  C1x C    20.9758  -44.4990
            50  C1b C    19.9172  -46.7811
            51  C1b C    31.6434  -34.9311
            52  N1b N    33.8729  -34.7348
            53  C8x C    31.6842  -43.3082
            54  C8x C    34.0775  -43.1517
            55  C1x C    20.6955  -42.2624
            56  C5a C    23.0500  -41.6080
            57  C1x C    20.0352  -43.4787
            58  C1b C    18.7207  -46.1536
            59  C8y C    30.3813  -35.5259
            60  C5a C    33.8729  -33.3476
            61  C8x C    32.9508  -43.9497
            62  N1b N    23.0338  -40.1298
            63  O5a O    24.3646  -42.2624
            64  N1a N    17.5427  -46.8919
            65  C8x C    30.1324  -36.9386
            66  N5x N    29.1124  -34.8786
            67  C1c C    35.0108  -32.5892
            68  O5a O    32.6435  -32.7201
            69  C1c C    21.9073  -39.4826
            70  N4x N    28.7197  -37.1350
            71  C8x C    28.0922  -35.8729
            72  N1b N    34.9911  -31.1708
            73  C1b C    36.2473  -33.2309
            74  C5a C    21.9178  -38.0896
            75  C1c C    20.7996  -40.2935
            76  C5a C    36.1491  -30.4054
            77  C1b C    36.2473  -34.6238
            78  N1b N    20.7410  -37.4621
            79  O5a O    23.1284  -37.3312
            80  C1a C    20.7690  -41.6806
            81  C1a C    19.5830  -39.6460
            82  C1c C    36.1233  -29.0183
            83  O5a O    37.3456  -31.0528
            84  C6a C    37.4637  -35.2314
            85  C1b C    20.7014  -36.0493
            86  N1b N    37.2172  -28.2471
            87  C1b C    34.8428  -28.3908
            88  O6a O    37.4463  -36.6441
            89  O6a O    38.6345  -34.4601
            90  C5a C    19.5245  -35.4021
            91  C5a C    37.2417  -26.8473
            92  C1b C    34.8742  -26.9980
            93  N1b N    19.5047  -33.9893
            94  O5a O    18.3479  -36.1534
            95  C1c C    38.3857  -26.0759
            96  O5a O    36.0251  -26.2127
            97  S2a S    33.6836  -26.3705
            98  C1c C    20.6255  -33.2368
            99  N1b N    38.3599  -24.7332
            100 C1b C    39.6219  -26.7035
            101 C1a C    32.4613  -27.4035
            102 C5a C    20.6628  -31.8438
            103 C1b C    21.8991  -33.8981
            104 C5a C    39.4667  -23.8980
            105 O1a O    39.6348  -28.0965
            106 N1b N    21.8196  -31.0726
            107 O5a O    19.4661  -31.1966
            108 C1b C    23.0500  -33.1327
            109 C1c C    39.4982  -22.5050
            110 O5a O    40.7531  -24.5453
            111 C1c C    21.8137  -29.6598
            112 C1b C    24.2467  -33.7204
            113 C1b C    40.6549  -21.7466
            114 N1b N    38.2817  -21.8377
            115 C5a C    22.9518  -28.8945
            116 C1b C    20.6032  -29.0780
            117 C1b C    25.4045  -32.9622
            118 C8y C    40.6421  -20.3538
            119 C5a C    37.1108  -22.6489
            120 N1b N    22.9518  -27.5273
            121 O5a O    24.1682  -29.5617
            122 C1b C    19.4464  -29.8036
            123 N1a N    26.6209  -33.6035
            124 C8x C    39.3300  -19.7123
            125 C8x C    41.7930  -19.5685
            126 C1c C    35.9072  -22.0214
            127 O5a O    37.0735  -23.7616
            128 C1c C    24.0584  -26.7819
            129 C1b C    18.2497  -29.1890
            130 C8x C    39.3602  -18.2995
            131 C8x C    41.7733  -18.1558
            132 C1b C    34.7364  -22.7797
            133 N1a N    35.9445  -20.6284
            134 C5a C    24.0899  -25.3562
            135 C1b C    25.3321  -27.4035
            136 C1b C    17.0333  -29.9345
            137 C8y C    40.5569  -17.5283
            138 O1a O    34.6863  -24.2906
            139 N1b N    25.2363  -24.6107
            140 O5a O    22.9191  -24.7217
            141 C1b C    26.5030  -26.6451
            142 N1a N    15.8753  -29.2872
            143 O1a O    40.4984  -16.1155
            144 C1c C    25.2667  -23.2177
            145 C1b C    27.6997  -27.2726
            146 C5a C    24.0700  -22.5835
            147 C1b C    26.4632  -22.4526
            148 N1b N    28.8703  -26.5071
            149 N1y N    24.1075  -21.1776
            150 O5a O    22.8536  -23.3486
            151 C1b C    27.6598  -23.0742
            152 C2c C    30.0869  -27.1161
            153 C1y C    24.6976  -19.8830
            154 C1x C    22.6772  -20.9614
            155 C1b C    28.7978  -22.3087
            156 N1a N    31.2248  -26.3764
            157 N2a N    30.1066  -28.5217
            158 C1x C    23.7430  -18.9410
            159 C5a C    25.8755  -19.1175
            160 C1x C    22.5067  -19.5685
            161 N1b N    30.0085  -22.9561
            162 N1b N    25.9057  -17.7505
            163 O5a O    27.0919  -19.7848
            164 C2c C    31.1852  -22.1977
            165 C1c C    26.9237  -16.9652
            166 N1a N    32.3888  -22.7797
            167 N2a N    31.2167  -20.7849
            168 C5a C    26.9740  -15.5466
            169 C1c C    28.2290  -17.6066
            170 N1b N    28.0608  -14.7882
            171 O5a O    25.7576  -14.9447
            172 C1a C    29.3868  -16.8412
            173 C1a C    28.2290  -19.0193
            174 C1c C    28.0922  -13.3754
            175 C5a C    29.2688  -12.6357
            176 C1b C    26.8957  -12.7865
            177 N1b N    29.2303  -11.2171
            178 O5a O    30.5051  -13.2971
            179 C1b C    25.7048  -13.5718
            180 C1c C    30.4069  -10.4717
            181 C1b C    24.4686  -12.9044
            182 C5a C    30.3615   -9.1576
            183 C1c C    31.6761  -11.1189
            184 C1b C    23.2919  -13.6699
            185 N1b N    29.0223   -8.4353
            186 O5a O    31.5779   -8.4130
            187 C1a C    31.7215  -12.5703
            188 C1a C    32.8726  -10.3735
            189 N1a N    22.0556  -13.0026
            190 C1c C    29.0667   -7.0003
            191 C5a C    30.2387   -6.1570
            192 C1b C    27.7580   -6.2559
            193 N1y N    30.2633   -4.7514
            194 O5a O    31.6175   -6.9016
            195 C8y C    26.4831   -7.0988
            196 C1y C    31.5978   -4.0832
            197 C1x C    29.2630   -3.6122
            198 C8x C    25.1884   -6.3390
            199 C8x C    26.4715   -8.5340
            200 C1x C    31.3816   -2.5718
            201 C6a C    32.9124   -4.7514
            202 C1x C    29.9103   -2.3427
            203 C8x C    23.9393   -7.1212
            204 C8x C    25.3063   -9.3162
            205 O6a O    34.1672   -3.9459
            206 O6a O    32.9007   -6.2559
            207 C8y C    23.9218   -8.6866
            208 O1a O    22.7357   -9.3772
BOND        216
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9    10   5 1 #Up
            10    8  11 2
            11   10  12 1
            12   10  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 2
            16   14  17 1
            17   14  18 2
            18   15  19 1
            19   17  20 1
            20   17  21 1 #Down
            21   19  22 1
            22   20  23 1
            23   21  24 1
            24   22  25 1
            25   22  26 2
            26   23  27 1
            27   23  28 2
            28   24  29 1
            29   25  30 1
            30   27  31 1
            31   27  32 1 #Up
            32   29  33 1
            33   30  34 1
            34   30  35 1 #Up
            35   31  36 1
            36   32  37 1
            37   33  38 1
            38   34  39 1
            39   34  40 2
            40   35  41 1
            41   36  42 1
            42   36  43 2
            43   37  44 2
            44   37  45 1
            45   38  46 1
            46   38  47 2
            47   39  48 1
            48   39  49 1
            49   41  50 1
            50   42  51 1 #Down
            51   42  52 1
            52   44  53 1
            53   45  54 2
            54   48  55 1
            55   48  56 1 #Up
            56   49  57 1
            57   50  58 1
            58   51  59 1
            59   52  60 1
            60   53  61 2
            61   56  62 1
            62   56  63 2
            63   58  64 1
            64   59  65 2
            65   59  66 1
            66   60  67 1
            67   60  68 2
            68   62  69 1
            69   65  70 1
            70   66  71 2
            71   67  72 1
            72   67  73 1 #Up
            73   69  74 1
            74   69  75 1 #Up
            75   72  76 1
            76   73  77 1
            77   74  78 1
            78   74  79 2
            79   75  80 1
            80   75  81 1
            81   76  82 1
            82   76  83 2
            83   77  84 1
            84   78  85 1
            85   82  86 1
            86   82  87 1 #Down
            87   84  88 1
            88   84  89 2
            89   85  90 1
            90   86  91 1
            91   87  92 1
            92   90  93 1
            93   90  94 2
            94   91  95 1
            95   91  96 2
            96   92  97 1
            97   93  98 1
            98   95  99 1
            99   95 100 1 #Up
            100  97 101 1
            101  98 102 1
            102  98 103 1 #Up
            103  99 104 1
            104 100 105 1
            105 102 106 1
            106 102 107 2
            107 103 108 1
            108 104 109 1
            109 104 110 2
            110 106 111 1
            111 108 112 1
            112 109 113 1
            113 109 114 1 #Up
            114 111 115 1
            115 111 116 1 #Down
            116 112 117 1
            117 113 118 1
            118 114 119 1
            119 115 120 1
            120 115 121 2
            121 116 122 1
            122 117 123 1
            123 118 124 1
            124 118 125 2
            125 119 126 1
            126 119 127 2
            127 120 128 1
            128 122 129 1
            129 124 130 2
            130 125 131 1
            131 126 132 1
            132 126 133 1
            133 128 134 1
            134 128 135 1 #Up
            135 129 136 1
            136 130 137 1
            137 132 138 1
            138 134 139 1
            139 134 140 2
            140 135 141 1
            141 136 142 1
            142 137 143 1
            143 139 144 1
            144 141 145 1
            145 144 146 1
            146 144 147 1 #Up
            147 145 148 1
            148 146 149 1
            149 146 150 2
            150 147 151 1
            151 148 152 1
            152 149 153 1
            153 149 154 1
            154 151 155 1
            155 152 156 1
            156 152 157 2
            157 153 158 1
            158 153 159 1 #Up
            159 154 160 1
            160 155 161 1
            161 159 162 1
            162 159 163 2
            163 161 164 1
            164 162 165 1
            165 164 166 1
            166 164 167 2
            167 165 168 1
            168 165 169 1 #Down
            169 168 170 1
            170 168 171 2
            171 169 172 1
            172 169 173 1
            173 170 174 1
            174 174 175 1
            175 174 176 1 #Up
            176 175 177 1
            177 175 178 2
            178 176 179 1
            179 177 180 1
            180 179 181 1
            181 180 182 1
            182 180 183 1 #Down
            183 181 184 1
            184 182 185 1
            185 182 186 2
            186 183 187 1
            187 183 188 1
            188 184 189 1
            189 185 190 1
            190 190 191 1
            191 190 192 1 #Up
            192 191 193 1
            193 191 194 2
            194 192 195 1
            195 193 196 1
            196 193 197 1
            197 195 198 2
            198 195 199 1
            199 196 200 1
            200 196 201 1 #Up
            201 197 202 1
            202 198 203 1
            203 199 204 2
            204 201 205 1
            205 201 206 2
            206 203 207 2
            207 207 208 1
            208   6   7 1
            209   9  11 1
            210  54  61 1
            211  55  57 1
            212  70  71 1
            213 131 137 2
            214 158 160 1
            215 200 202 1
            216 204 207 1

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