| Entry |
|
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| Name |
Cimetidine (JP18/USP/INN);
Tagamet (TN) |
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| Product |
|
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| Generic |
|
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| Formula |
C10H16N6S
|
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| Exact mass |
252.1157
|
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| Mol weight |
252.34
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
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| Remark |
| Therapeutic category: | 2325 |
| Product (DG00017): | D00295<JP/US> D03503<US> |
|
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| Efficacy |
Anti-ulcerative, H2 receptor antagonist |
|---|
| Disease |
Duodenal ulcer [DS: H01634] Gastric ulcer [DS: H01634] Gastroesophageal reflux disease [DS: H01602] Zollinger-Ellison syndrome [DS: H01522] |
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565], CYP3A4 [HSA: 1576]
|
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| Structure map |
| map07227 | Histamine H2/H3 receptor agonists/antagonists |
|
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| Other map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BA H2-receptor antagonists
A02BA01 Cimetidine
D00295 Cimetidine (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Histamine2 (H2) Receptor Antagonists
Cimetidine
D00295 Cimetidine (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
23 Digestive organ agents
232 Peptic ulcer agents
2325 H2 blockers
D00295 Cimetidine (JP18/USP/INN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for digestive organs
09 Histamine H2 receptor blocker containing drugs
D00295 Cimetidine (JP18/USP/INN)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
Inorganic and organic chemicals
Cimetidine
D00295 Cimetidine (JP18/USP/INN)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00017 Cimetidine
D00295 Cimetidine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00017 Cimetidine
D00295 Cimetidine
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00017 Cimetidine
D00295 Cimetidine
Drug classes [BR:br08332]
Gastrointestinal agent
DG01481 Histamine receptor H2 antagonist
D00295 Cimetidine
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH2
D00295 Cimetidine (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00295 Cimetidine
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00295
Rx-to-OTC switch list in the USA [br08315.html]
D00295
Rx-to-OTC switch list in Japan [br08314.html]
D00295
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00017 Cimetidine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00017 Cimetidine
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00017 Cimetidine
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 17
1 C1b C 24.5609 -17.1206
2 S2a S 25.7722 -16.4242
3 C1b C 26.9833 -17.1206
4 C1b C 28.1944 -16.4242
5 N1b N 29.4055 -17.1206
6 C2c C 30.6226 -16.4242
7 N2b N 30.6226 -15.0201
8 N1b N 31.8337 -17.1206
9 C3b C 31.8337 -14.3237
10 C1a C 33.0449 -16.4242
11 N3a N 33.0598 -13.6286
12 C8y C 23.3693 -16.4301
13 N5x N 23.3693 -15.0301
14 C8x C 22.0378 -14.5975
15 N4x N 21.2149 -15.7301
16 C8y C 22.0378 -16.8627
17 C1a C 21.6042 -18.1971
BOND 17
1 1 2 1
2 2 3 1
3 3 4 1
4 4 5 1
5 5 6 1
6 6 7 2
7 6 8 1
8 7 9 1
9 8 10 1
10 9 11 3
11 1 12 1
12 12 13 1
13 13 14 2
14 14 15 1
15 15 16 1
16 12 16 2
17 16 17 1
|
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