KEGG   DISEASE: Peptic ulcer
H01634                      Disease                                
Peptic ulcer
Peptic ulcer is a common disorder of gastrointestinal system characterized by mucosal damage secondary to pepsin and gastric acid secretion. It usually occurs in the stomach and proximal duodenum. Typical symptoms include episodic burning epigastric pain, loss of appetite, and weight loss. Pain usually occurs two to five hours after meals or on an empty stomach. The most common causes of peptic ulcer are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Smoking increases the risk of ulcer recurrence and slows healing. Most patients are treated successfully with eradication of H. pylori and/or avoidance of NSAIDs, along with the appropriate use of antisecretory therapy. About 25 percent of patients with peptic ulcer have a serious complication such as hemorrhage, perforation, or gastric outlet obstruction. Administration of proton pump inhibitors (PPIs) and endoscopic therapy control most bleeds.
Digestive system disease
Human diseases [BR:br08402]
 Digestive system diseases
  Gastrointestinal diseases
   H01634  Peptic ulcer
Human diseases in ICD-11 classification [BR:br08403]
 13 Diseases of the digestive system
  Diseases of the stomach or the duodenum
   Ulcer of stomach or duodenum
    DA60  Gastric ulcer
     H01634  Peptic ulcer
    DA61  Peptic ulcer, site unspecified
     H01634  Peptic ulcer
    DA62  Anastomotic ulcer
     H01634  Peptic ulcer
    DA63  Duodenal ulcer
     H01634  Peptic ulcer
Cimetidine [DR:D00295]
Cimetidine hydrochloride [DR:D03503]
Ranitidine hydrochloride [DR:D00673]
Famotidine [DR:D00318]
Nizatidine [DR:D00440]
Misoprostol [DR:D00419]
Omeprazole [DR:D00455]
Omeprazole magnesium [DR:D05259]
Lansoprazole [DR:D00355]
Rabeprazole sodium [DR:D00724]
Esomeprazole magnesium [DR:D01984]
Esomeprazole sodium [DR:D04056]
Esomeprazole strontium [DR:D10120]
Esomeprazole magnesium dihydrate [DR:D11114]
Sucralfate [DR:D00446]
Glycopyrrolate [DR:D00540]
Propantheline bromide [DR:D00481]
Hyoscyamine sulfate [DR:D00719]
Chlordiazepoxide hydrochloride and clidinium bromide [DR:D10247]
Ibuprofen and famotidine [DR:D11575]
Naproxen and esomeprazole magnesium [DR:D11576]
Methscopolamine bromide [DR:D00715]
Omeprazole and sodium bicarbonate [DR:D11706]
See also H00320 Helicobacter pylori infection.
Other DBs
ICD-11: DA60 DA61 DA62 DA63
ICD-10: K25 K26 K27 K28
MeSH: D010437
Ramakrishnan K, Salinas RC
Peptic ulcer disease.
Am Fam Physician 76:1005-12 (2007)
Fashner J, Gitu AC
Diagnosis and Treatment of Peptic Ulcer Disease and H. pylori Infection.
Am Fam Physician 91:236-42 (2015)
Weir DG
Peptic ulceration.
Br Med J (Clin Res Ed) 296:195-200 (1988)

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