Homo sapiens (human): 3274
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Entry
3274 CDS
T01001
Symbol
HRH2, H2R, HH2R
Name
(RefSeq) histamine H2 receptor isoform 1
KO
K04150
histamine receptor H2
Organism
hsa
Homo sapiens (human)
Pathway
hsa04020
Calcium signaling pathway
hsa04080
Neuroactive ligand-receptor interaction
hsa04082
Neuroactive ligand signaling
hsa04971
Gastric acid secretion
Drug target
Betazole:
D01187
Cimetidine (
DG00017
):
D00295
<JP/US>
D03503
<US>
Dalcotidine:
D01698
Donetidine:
D03889
Etintidine hydrochloride:
D04098
Famotidine:
D00318
<JP/US>
Histamine:
D08040
Histamine phosphate:
D04445
<US>
Icotidine:
D04494
Impromidine hydrochloride:
D04517
Lafutidine:
D01131
<JP>
Lavoltidine succinate:
D04680
Lupitidine hydrochloride:
D04794
Methantheline (
DG00036
):
D00721
Metiamide:
D05004
Niperotidine:
D07072
Nizatidine:
D00440
<JP/US>
Osutidine:
D01193
Oxmetidine (
DG01225
):
D05306
D05307
Pibutidine hydrochloride:
D01861
Ranitidine (
DG00018
):
D00422
D00673
<US>
Ranitidine bismuth citrate:
D05699
Roxatidine (
DG00019
):
D01467
<JP>
D08494
D08495
Sufotidine:
D05939
Tiotidine:
D06157
Zaltidine hydrochloride:
D06355
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04020 Calcium signaling pathway
3274 (HRH2)
09133 Signaling molecules and interaction
04080 Neuroactive ligand-receptor interaction
3274 (HRH2)
04082 Neuroactive ligand signaling
3274 (HRH2)
09150 Organismal Systems
09154 Digestive system
04971 Gastric acid secretion
3274 (HRH2)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04030 G protein-coupled receptors [BR:
hsa04030
]
3274 (HRH2)
G protein-coupled receptors [BR:
hsa04030
]
Rhodopsin family
Biogenic amine
Histamine
3274 (HRH2)
SSDB
Ortholog
Paralog
GFIT
Motif
Pfam:
7tm_1
7TM_GPCR_Srsx
7tm_4
Motif
Other DBs
NCBI-GeneID:
3274
NCBI-ProteinID:
NP_001124527
OMIM:
142703
HGNC:
5183
UniProt:
P25021
Structure
PDB
PDBj
LinkDB
All DBs
Position
5:175658071..175710756
Genome browser
AA seq
397 aa
AA seq
DB search
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSL
AITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAV
MDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNE
VYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVM
GAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQ
QLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDRP
WLCLPECWSVELTHSFIHLFIHSFANIHPIPTTCQEL
NT seq
1194 nt
NT seq
+upstream
nt +downstream
nt
atggcacccaatggcacagcctcttccttttgcctggactctaccgcatgcaagatcacc
atcaccgtggtccttgcggtcctcatcctcatcaccgttgctggcaatgtggtcgtctgt
ctggccgtgggcttgaaccgccggctccgcaacctgaccaattgtttcatcgtgtccttg
gctatcactgacctgctcctcggcctcctggtgctgcccttctctgccatctaccagctg
tcctgcaagtggagctttggcaaggtcttctgcaatatctacaccagcctggatgtgatg
ctctgcacagcctccattcttaacctcttcatgatcagcctcgaccggtactgcgctgtc
atggacccactgcggtaccctgtgctggtcaccccagttcgggtcgccatctctctggtc
ttaatttgggtcatctccattaccctgtcctttctgtctatccacctggggtggaacagc
aggaacgagaccagcaagggcaatcataccacctctaagtgcaaagtccaggtcaatgaa
gtgtacgggctggtggatgggctggtcaccttctacctcccgctactgatcatgtgcatc
acctactaccgcatcttcaaggtcgcccgggatcaggccaagaggatcaatcacattagc
tcctggaaggcagccaccatcagggagcacaaagccacagtgacactggccgccgtcatg
ggggccttcatcatctgctggtttccctacttcaccgcgtttgtgtaccgtgggctgaga
ggggatgatgccatcaatgaggtgttagaagccatcgttctgtggctgggctatgccaac
tcagccctgaaccccatcctgtatgctgcgctgaacagagacttccgcaccgggtaccaa
cagctcttctgctgcaggctggccaaccgcaactcccacaaaacttctctgaggtccaac
gcctctcagctgtccaggacccaaagccgagaacccaggcaacaggaagagaaacccctg
aagctccaggtgtggagtgggacagaagtcacggccccccagggagccacagacagacca
tggctttgccttccagaatgctggtctgtggaactgacccattcattcattcatttgttc
attcattcatttgcaaacattcatccaattcccaccacatgccaggaattatga
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