KEGG   DRUG: FurosemideHelp
Entry
D00331                      Drug                                   

Name
Furosemide (JP17/USP/INN);
Frusemide;
Lasix (TN)
Product
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Golden State Medical Supply), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (Hospira), FUROSEMIDE (Hospira), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Mylan Institutional), FUROSEMIDE (Mylan Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (Safecor Health), FUROSEMIDE (Sandoz), LASIX (Sanofi-Aventis U.S. LLC), FUROSEMIDE (State of Florida DOH Central Pharmacy), LASIX (Validus Pharmaceuticals LLC), FUROSEMIDE (West-Ward Pharmaceuticals Corp.)
  Generic
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Aidarex Pharmaceuticals LLC), FUROSEMIDE (Aidarex Pharmaceuticals LLC), FUROSEMIDE (Amneal Biosciences), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Apotheca), FUROSEMIDE (Apotheca), FUROSEMIDE (Atlantic Biologicals Corps), FUROSEMIDE (Atlantic Biologicals Corps), FUROSEMIDE (Baxter Healthcare Corporation), FUROSEMIDE (Blenheim Pharmacal), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Cardinal Health), FUROSEMIDE (Clinical Solutions Wholesale), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (Contract Pharmacy Services-PA), FUROSEMIDE (DIRECT RX), FUROSEMIDE (DIRECT RX), FUROSEMIDE (Excellium Pharmaceutical), FUROSEMIDE (General Injectables & Vaccines), FUROSEMIDE (Heritage Pharmaceuticals), FUROSEMIDE (Heritage Pharmaceuticals), DIASCREEN 12-PANEL MEDICATED COLLECTION SYSTEM (IT3 Medical LLC), FUROSEMIDE (IT3 Medical LLC), FUROSEMIDE (IT3 Medical LLC), TOXYCOLOGY MEDICATED COLLECTION SYSTEM (IT3 Medical LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Leading Pharma), FUROSEMIDE (Mas Management Group), FUROSEMIDE (McKesson Packaging Services a business unit of McKesson Corporation), FUROSEMIDE (MedVantx), FUROSEMIDE (MedVantx), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Morton Grove Pharmaceuticals), FUROSEMIDE (New Horizon Rx Group), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Precision Dose), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), LASIX (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (QPharma), FUROSEMIDE (QPharma), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (RPK Pharmaceuticals), FUROSEMIDE (Ranbaxy Pharmaceuticals), FUROSEMIDE (ReadyMeds), FUROSEMIDE (Rebel Distirbutors Corp), FUROSEMIDE (Rebel Distributors Corp), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (Solco Healthcare LLC), FUROSEMIDE (St Marys Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (State of Florida DOH Central Pharmacy), FUROSEMIDE (TYA Pharmaceuticals), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Unit Dose Services), FUROSEMIDE (Wockhardt USA LLC.)
Formula
C12H11ClN2O5S
Exact mass
330.0077
Mol weight
330.7441
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Transporter substrate
 DG02859  SLC22A6 (OAT1) substrate
 DG02860  SLC22A8 (OAT3) substrate
Remark
Same as: C07017
Therapeutic category: 2139 2149
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Drug interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D00331  Furosemide (JP17/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D00331  Furosemide (JP17/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00331  Furosemide (JP17/USP/INN)
   214  Antihypertensives
    2149  Others
     D00331  Furosemide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00331  Furosemide (JP17/USP/INN) <JP/US>
    SLC12A2 (NKCC1)
     D00331  Furosemide (JP17/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00331  Furosemide
  D00331  Furosemide tablets
  D00331  Furosemide injection
Drug classes of therapeutic agents [br08360.html]
 Cardiovascular agents
  D00331
BRITE hierarchy
Other DBs
CAS: 54-31-9
PubChem: 7847397
ChEBI: 47426
ChEMBL: CHEMBL35
DrugBank: DB00695
PDB-CCD: FUN[PDBj]
LigandBox: D00331
NIKKAJI: J1.913E
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    33.0198  -14.5445
            2   C8y C    31.8035  -15.2369
            3   C8x C    34.2301  -15.2545
            4   C6a C    33.0314  -13.1420
            5   C8x C    31.7978  -16.6395
            6   N1b N    30.5932  -14.5270
            7   C8y C    34.2185  -16.6511
            8   O6a O    31.8211  -12.4379
            9   O6a O    34.2477  -12.4553
            10  C8y C    33.0024  -17.3436
            11  C1b C    29.3827  -15.2253
            12  S4a S    35.4290  -17.3552
            13  X   Cl   32.9965  -18.7402
            14  C8y C    28.1781  -14.5153
            15  N1a N    36.6336  -18.0652
            16  O3c O    34.7364  -18.5772
            17  O3c O    36.1506  -16.1623
            18  O2x O    28.1781  -13.1153
            19  C8x C    26.8466  -12.6826
            20  C8x C    26.0237  -13.8153
            21  C8x C    26.8466  -14.9479
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

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