KEGG   DRUG: Furosemide
Entry
D00331                      Drug                                   
Name
Furosemide (JP18/USP/INN);
Frusemide;
Lasix (TN)
Product
FUROSCIX (scPharmaceuticals), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Chartwell RX), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Fresenius Kabi USA), FUROSEMIDE (Golden State Medical Supply), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (HF Acquisition Co LLC), FUROSEMIDE (Hikma Pharmaceuticals USA), FUROSEMIDE (Hikma Pharmaceuticals USA), FUROSEMIDE (Hospira), FUROSEMIDE (Hospira), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (Phlow Corporation), LASIX (Validus Pharmaceuticals LLC)
  Generic
FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (A-S Medication Solutions), FUROSEMIDE (Accord Healthcare), FUROSEMIDE (Amneal Pharmaceuticals LLC), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Aphena Pharma Solutions - Tennessee), FUROSEMIDE (Athenex Pharmaceutical Division), FUROSEMIDE (AvKARE), FUROSEMIDE (Avenacy), FUROSEMIDE (Baxter Healthcare Corporation), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Bryant Ranch Prepack), FUROSEMIDE (Calvin Scott &), FUROSEMIDE (Calvin Scott &), FUROSEMIDE (Cardinal Health 107), FUROSEMIDE (Civica), FUROSEMIDE (DIRECT RX), FUROSEMIDE (Devatis), FUROSEMIDE (Direct_Rx), FUROSEMIDE (Eugia US LLC), FUROSEMIDE (Gland Pharma Limited), FUROSEMIDE (Graviti Pharmaceuticals Private Limited), FUROSEMIDE (Henry Schein), FUROSEMIDE (Henry Schein), FUROSEMIDE (Henry Schein), FUROSEMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), FUROSEMIDE (Ipca Laboratories Limited), FUROSEMIDE (Lake Erie Medical DBA Quality Care Products LLC), FUROSEMIDE (Leading Pharma), FUROSEMIDE (Lifestar Pharma LLC), FUROSEMIDE (Major Pharmaceuticals), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Medical Purchasing Solutions), FUROSEMIDE (Meitheal Pharmaceuticals), FUROSEMIDE (NCS HealthCare of KY), FUROSEMIDE (NorthStar Rx LLC), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (Northwind Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (NuCare Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (PD-Rx Pharmaceuticals), FUROSEMIDE (Precision Dose), FUROSEMIDE (Precision Dose), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Preferred Pharmaceuticals), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (Proficient Rx LP), FUROSEMIDE (QPharma), FUROSEMIDE (QPharma), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (REMEDYREPACK), FUROSEMIDE (RPK Pharmaceuticals), FUROSEMIDE (RPK Pharmaceuticals), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (RedPharm Drug), FUROSEMIDE (Redpharm Drug), FUROSEMIDE (Rising Pharma Holdings), FUROSEMIDE (ST. MARY'S MEDICAL PARK PHARMACY), FUROSEMIDE (Sagent Pharmaceuticals), FUROSEMIDE (Solco Healthcare LLC), FUROSEMIDE (St Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy), FUROSEMIDE (St. Mary's Medical Park Pharmacy)
Formula
C12H11ClN2O5S
Exact mass
330.0077
Mol weight
330.74
Structure
Simcomp
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01747  Furosemide type diuretic
 DG01748  Loop diuretic
  DG01747  Furosemide type diuretic
Transporter substrate
 DG02920  ABCC4 substrate
 DG02859  SLC22A6 substrate
 DG02860  SLC22A8 substrate
Remark
Same as: C07017
Therapeutic category: 2139
ATC code: C03CA01
Chemical structure group: DG00272
Product (DG00272): D00331<JP/US>
Efficacy
Diuretic, Na-K-Cl cotransporter inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Loop diuretic
Sulfonamide derivative
Target
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
SLC12A2 (NKCC1) [HSA:6558] [KO:K10951]
Metabolism
Transporter: SLC22A6 [HSA:9356], SLC22A8 [HSA:9376], ABCC4 [HSA:10257]
Interaction
Structure map
map07017  Sulfonamide derivatives - diuretics
map07055  Sulfonamide derivatives - overview
map07233  Ion transporter inhibitors
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03C HIGH-CEILING DIURETICS
    C03CA Sulfonamides, plain
     C03CA01 Furosemide
      D00331  Furosemide (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Loop
   Furosemide
    D00331  Furosemide (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   213  Diuretics
    2139  Others
     D00331  Furosemide (JP18/USP/INN)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00272  Furosemide
     D00331  Furosemide
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00272  Furosemide
     D00331  Furosemide
 Transporter substrate
  DG02920  ABCC4 substrate
   DG00272  Furosemide
    D00331  Furosemide
  DG02859  SLC22A6 substrate
   DG00272  Furosemide
    D00331  Furosemide
  DG02860  SLC22A8 substrate
   DG00272  Furosemide
    D00331  Furosemide
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00331  Furosemide (JP18/USP/INN) <JP/US>
    SLC12A2 (NKCC1)
     D00331  Furosemide (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00331  Furosemide
  D00331  Furosemide tablets
  D00331  Furosemide injection
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00331
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01690  Sulfonamide diuretic
   DG01747  Furosemide type diuretic
    DG00272  Furosemide
  DG01748  Loop diuretic
   DG01747  Furosemide type diuretic
    DG00272  Furosemide
 Transporter substrate
  DG02920  ABCC4 substrate
   DG00272  Furosemide
  DG02859  SLC22A6 substrate
   DG00272  Furosemide
  DG02860  SLC22A8 substrate
   DG00272  Furosemide
Other DBs
CAS: 54-31-9
PubChem: 7847397
ChEBI: 47426
PDB-CCD: FUN[PDBj]
LigandBox: D00331
NIKKAJI: J1.913E
LinkDB
KCF data

ATOM        21
            1   C8y C    33.0198  -14.5445
            2   C8y C    31.8035  -15.2369
            3   C8x C    34.2301  -15.2545
            4   C6a C    33.0314  -13.1420
            5   C8x C    31.7978  -16.6395
            6   N1b N    30.5932  -14.5270
            7   C8y C    34.2185  -16.6511
            8   O6a O    31.8211  -12.4379
            9   O6a O    34.2477  -12.4553
            10  C8y C    33.0024  -17.3436
            11  C1b C    29.3827  -15.2253
            12  S4a S    35.4290  -17.3552
            13  X   Cl   32.9965  -18.7402
            14  C8y C    28.1781  -14.5153
            15  N1a N    36.6336  -18.0652
            16  O3c O    34.7364  -18.5772
            17  O3c O    36.1506  -16.1623
            18  O2x O    28.1781  -13.1153
            19  C8x C    26.8466  -12.6826
            20  C8x C    26.0237  -13.8153
            21  C8x C    26.8466  -14.9479
BOND        22
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 1
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   12  16 2
            16   12  17 2
            17    7  10 1
            18   14  18 1
            19   18  19 1
            20   19  20 2
            21   20  21 1
            22   14  21 2

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