KEGG   DRUG: GanciclovirHelp
Entry
D00333                      Drug                                   

Name
Ganciclovir (JAN/USP/INN);
Cytovene (TN);
Vitrasert (TN);
Zirgan (TN)
Product
  Generic
Formula
C9H13N5O4
Exact mass
255.0968
Mol weight
255.2306
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG02840  Herpesvirus DNA polymerase inhibitor
 DG01937  Anti-cytomegalovirus agent
Remark
Same as: C07019
Therapeutic category: 6250
ATC code: J05AB06 S01AD09
Chemical structure group: DG00646
Product (DG00646): D00333<JP/US> D04301<US>
Efficacy
Antiviral, DNA polymerase inhibitor
  Disease
CMV retinitis, Prevention of CMV disease [DS:H00368]
Acute herpetic keratitis [DS:H00365]
Target
Herpesvirus DNA polymerase [KO:K18964]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AB Nucleosides and nucleotides excl. reverse transcriptase inhibitors
     J05AB06 Ganciclovir
      D00333  Ganciclovir (JAN/USP/INN) <JP/US>
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AD Antivirals
     S01AD09 Ganciclovir
      D00333  Ganciclovir (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-cytomegalovirus (CMV) Agents
   Ganciclovir
    D00333  Ganciclovir (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00333  Ganciclovir (JAN/USP/INN)
Antiinfectives [br08350.html]
 Antivirals
  D00333
Prodrugs [br08324.html]
 D00333
BRITE hierarchy
Other DBs
CAS: 82410-32-0
PubChem: 7847399
ChEBI: 465284
ChEMBL: CHEMBL182
DrugBank: DB01004
PDB-CCD: GA2[PDBj]
LigandBox: D00333
NIKKAJI: J22.096E
LinkDB All DBs
KCF data Show

ATOM        18
            1   N4y N    23.5894  -15.7792
            2   C8y C    24.8354  -15.3006
            3   C8y C    24.8570  -13.9009
            4   N5x N    23.5108  -13.5146
            5   C8x C    22.7274  -14.6754
            6   N5x N    26.2117  -15.9583
            7   C8y C    27.3295  -15.2166
            8   N4x N    27.2810  -13.8170
            9   C8y C    26.0446  -13.1592
            10  O5x O    26.0667  -11.7758
            11  N1a N    28.5757  -15.8792
            12  C1b C    23.5894  -17.1792
            13  O2a O    22.3901  -17.8713
            14  C1c C    21.1762  -17.1701
            15  C1b C    19.9977  -17.8502
            16  C1b C    21.1759  -15.7504
            17  O1a O    19.9890  -15.0651
            18  O1a O    18.8022  -17.1595
BOND        19
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     1   5 1
            6     2   6 1
            7     6   7 2
            8     7   8 1
            9     8   9 1
            10    3   9 1
            11    9  10 2
            12    7  11 1
            13    1  12 1
            14   12  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 1
            18   16  17 1
            19   15  18 1

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