KEGG   DISEASE: Herpes simplex virus infection
Entry
H00365                      Disease                                
Name
Herpes simplex virus infection;
HSV infection
Description
Herpes simplex virus infection is caused by Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), Simplex viruses in the order Herpesvirales of dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. HSV infects the human host via mucosal surfaces or damaged skin, and most primary infections are asymptomatic. HSV-1 is mainly associated with orofacial lesions, yet it is also the cause of infectious blindness and viral encephalitis in adults. HSV-2 is mainly associated with genital lesions and neonatal encephalitis.
Category
Infectious disease
Brite
Infectious diseases [BR:br08401]
 Viral infections
  Infections caused by dsDNA viruses
   H00365  Herpes simplex virus infection
Human diseases in ICD-11 classification [BR:br08403]
 01 Certain infectious or parasitic diseases
  Predominantly sexually transmitted infections
   1A94  Anogenital herpes simplex infection
    H00365  Herpes simplex virus infection
  Viral infections characterised by skin or mucous membrane lesions
   1F00  Herpes simplex infections
    H00365  Herpes simplex virus infection
Pathway
hsa05168  Herpes simplex virus 1 infection
Network
nt06114  PI3K signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06133  RLR signaling (viruses)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06136  Complement activation (viruses)
nt06137  OAS/RNase L pathway (viruses)
nt06138  PKR-eIF2alpha signaling (viruses)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06168  Herpes simplex virus 1 (HSV-1)
Pathogen
Human herpesvirus 1 [GN:T40073]
Human herpesvirus 2 [GN:T40074]
Drug
Acyclovir [DR:D00222]
Acyclovir sodium [DR:D02764]
Penciclovir [DR:D05407]
Ganciclovir [DR:D00333]
Famciclovir [DR:D00317]
Valacyclovir hydrochloride [DR:D00398]
Foscarnet sodium [DR:D00579]
Trifluridine [DR:D00391]
Acyclovir and hydrochortisone [DR:D11627]
Other DBs
ICD-11: 1A94 1F00
ICD-10: B00 A60 O26.4 P35.2
MeSH: D006561
MedlinePlus: 001324
Reference
  Authors
Steiner I, Benninger F
  Title
Update on herpes virus infections of the nervous system.
  Journal
Curr Neurol Neurosci Rep 13:414 (2013)
DOI:10.1007/s11910-013-0414-8
Reference
  Authors
Hill GM, Ku ES, Dwarakanathan S
  Title
Herpes simplex keratitis.
  Journal
Dis Mon 60:239-46 (2014)
DOI:10.1016/j.disamonth.2014.03.003
Reference
  Authors
Tognarelli EI, Palomino TF, Corrales N, Bueno SM, Kalergis AM, Gonzalez PA
  Title
Herpes Simplex Virus Evasion of Early Host Antiviral Responses.
  Journal
Front Cell Infect Microbiol 9:127 (2019)
DOI:10.3389/fcimb.2019.00127
Reference
  Authors
Chisholm C, Lopez L
  Title
Cutaneous infections caused by Herpesviridae: a review.
  Journal
Arch Pathol Lab Med 135:1357-62 (2011)
DOI:10.5858/arpa.2010-0156-RS
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