Herpes simplex virus infection;
HSV infection

Herpes simplex virus infection is caused by Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), Simplex viruses in the order Herpesvirales of dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. HSV infects the human host via mucosal surfaces or damaged skin, and most primary infections are asymptomatic. HSV-1 is mainly associated with orofacial lesions, yet it is also the cause of infectious blindness and viral encephalitis in adults. HSV-2 is mainly associated with genital lesions and neonatal encephalitis.

Infectious disease

nt06114  PI3K signaling (viruses)
nt06121  TLR signaling (viruses and bacteria)
nt06122  IFN signaling (viruses)
nt06123  TNF signaling (viruses and bacteria)
nt06129  MHC presentation (viruses)
nt06131  Apoptosis (viruses and bacteria)
nt06133  RLR signaling (viruses)
nt06134  CGAS-STING signaling (viruses and bacteria)
nt06136  Complement activation (viruses)
nt06137  OAS/RNase L pathway (viruses)
nt06138  PKR-eIF2alpha signaling (viruses)
nt06140  Transcription (viruses)
nt06150  Cytokine-cytokine receptor interaction (viruses)
nt06168  Herpes simplex virus 1 (HSV-1)

Human herpesvirus 1 [GN:T40073]
Human herpesvirus 2 [GN:T40074]

Acyclovir [DR:D00222]
Acyclovir sodium [DR:D02764]
Penciclovir [DR:D05407]
Ganciclovir [DR:D00333]
Famciclovir [DR:D00317]
Valacyclovir hydrochloride [DR:D00398]
Foscarnet sodium [DR:D00579]
Trifluridine [DR:D00391]
Acyclovir and hydrochortisone [DR:D11627]

PMID:24142852

PMID:24906668

PMID:31114761

PMID:21970493