| Entry |
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| Name |
Herpes simplex virus infection;
HSV infection |
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| Description |
Herpes simplex virus infection is caused by Herpes simplex virus type 1 (HSV-1) and Herpes simplex virus type 2 (HSV-2), Simplex viruses in the order Herpesvirales of dsDNA viruses. Humans are the only natural host and reservoir for the HSV virus. HSV are human neurotropic viruses that establish latent infection in dorsal root ganglia (DRG) for the entire life of the host. HSV infects the human host via mucosal surfaces or damaged skin, and most primary infections are asymptomatic. HSV-1 is mainly associated with orofacial lesions, yet it is also the cause of infectious blindness and viral encephalitis in adults. HSV-2 is mainly associated with genital lesions and neonatal encephalitis.
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| Category |
Infectious disease
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| Brite |
Infectious diseases [BR:br08401]
Viral infections
Infections caused by dsDNA viruses
H00365 Herpes simplex virus infection
Human diseases in ICD-11 classification [BR:br08403]
01 Certain infectious or parasitic diseases
Predominantly sexually transmitted infections
1A94 Anogenital herpes simplex infection
H00365 Herpes simplex virus infection
Viral infections characterised by skin or mucous membrane lesions
1F00 Herpes simplex infections
H00365 Herpes simplex virus infection
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| Pathway |
| hsa05168 | Herpes simplex virus 1 infection |
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| Network |
nt06114 PI3K signaling (viruses) nt06121 TLR signaling (viruses and bacteria) nt06122 IFN signaling (viruses) nt06123 TNF signaling (viruses and bacteria) nt06129 MHC presentation (viruses) nt06131 Apoptosis (viruses and bacteria) nt06133 RLR signaling (viruses) nt06134 CGAS-STING signaling (viruses and bacteria) nt06136 Complement activation (viruses) nt06137 OAS/RNase L pathway (viruses) nt06138 PKR-eIF2alpha signaling (viruses) nt06140 Transcription (viruses) nt06150 Cytokine-cytokine receptor interaction (viruses) nt06168 Herpes simplex virus 1 (HSV-1) |
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| Element |
| N00560 | HSV gD to HVEM-NFKB signaling pathway |
| N00561 | HSV ICP0 to TLR2/4-NFKB signaling pathway |
| N00562 | HSV US3 to TLR2/4-NFKB signaling pathway |
| N00564 | HSV US3 to TLR3-NFKB signaling pathway |
| N00565 | HSV US11 to RIG-I-like receptor signaling pathway |
| N00566 | HSV UL36USP to RIG-I-like receptor signaling pathway |
| N00567 | HSV ICP34.5 to TBK1 signaling pathway |
| N00568 | HSV US3 to IRF3 signaling pathway |
| N00569 | HSV UL41 to cGAS-STING signaling pathway |
| N00570 | HSV ICP0 to cGAS-STING signaling pathway |
| N00572 | HSV ICP34.5 to PKR-eIF2alpha signaling pathway |
| N00573 | HSV US11 to PKR-eIF2alpha signaling pathway |
| N00574 | HSV US11 to oligoadenylate synthetase (OAS)/RNase L pathway |
| N00575 | HSV ICP27 to IFN signaling pathway |
| N00576 | HSV UL41/UL13 to IFN signaling pathway |
| N00577 | HSV UL41 to IFN signaling pathway |
| N00578 | HSV UL41 to IFN signaling pathway |
| N00579 | HSV ICP6 to extrinsic apoptotic pathway |
| N00580 | HSV ICP0 to crosstalk between extrinsic and intrinsic apoptotic pathways |
| N00581 | HSV ICP47 to antigen processing and presentation by MHC class I molecules |
| N00583 | HSV VP11/12 to PI3K signaling pathway |
| N00584 | HSV US3 to MTOR signaling pathway |
| N00585 | HSV US3 to intrinsic apoptotic pathway |
| N00587 | HSV ICP27 to Nuclear export of mRNA |
| N00588 | HSV VP16 to Oct-1-mediated transcription |
| N00589 | HSV gC to alternative pathway of complement activation |
| N00591 | HSV gB to antigen processing and presentation by MHC class II molecules |
| N00592 | HSV ICP0 to p53-mediated transcription |
| N01186 | HSV1 SgG1 to CCR signaling |
| N01187 | HSV2 SgG2 to CCR signaling |
| N01192 | HSV2 SgG2 to CCR signaling |
| N01222 | HSV1 SgG1 to CCR signaling |
| N01223 | HSV2 SgG2 to CCR signaling |
| N01227 | HSV1 SgG1 to CCR signaling |
| N01228 | HSV2 SgG2 to CCR signaling |
| N01244 | HSV1 SgG1 to CXCR signaling |
| N01245 | HSV2 SgG2 to CXCR signaling |
| N01249 | HSV1 SgG1 to CXCR signaling |
| N01250 | HSV2 SgG2 to CXCR signaling |
| N01256 | HSV1 SgG1 to CXCR signaling |
| N01257 | HSV2 SgG2 to CXCR signaling |
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| Pathogen |
Human herpesvirus 1 [GN: T40073] Human herpesvirus 2 [GN: T40074] |
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| Drug |
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| Other DBs |
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| Reference |
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| Authors |
Steiner I, Benninger F |
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| Title |
Update on herpes virus infections of the nervous system. |
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| Journal |
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| Reference |
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| Authors |
Hill GM, Ku ES, Dwarakanathan S |
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| Title |
Herpes simplex keratitis. |
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| Journal |
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| Reference |
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| Authors |
Tognarelli EI, Palomino TF, Corrales N, Bueno SM, Kalergis AM, Gonzalez PA |
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| Title |
Herpes Simplex Virus Evasion of Early Host Antiviral Responses. |
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| Journal |
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| Reference |
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| Authors |
Chisholm C, Lopez L |
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| Title |
Cutaneous infections caused by Herpesviridae: a review. |
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| Journal |
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| LinkDB |
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