KEGG   DRUG: LamivudineHelp
Entry
D00353                      Drug                                   

Name
Lamivudine (JAN/USP/INN);
Epivir (TN)
Product
  Generic
LAMIVUDINE (APPCO PHARMA LLC), LAMIVUDINE (American Health Packaging), LAMIVUDINE (American Health Packaging), LAMIVUDINE (Apotex Corp.), LAMIVUDINE (Apotex Corp.), LAMIVUDINE (Aurobindo Pharma Limited), LAMIVUDINE (Aurobindo Pharma Limited), LAMIVUDINE (Aurobindo Pharma Limited), LAMIVUDINE (AvPAK), LAMIVUDINE (Bryant Ranch Prepack), LAMIVUDINE (Camber Pharmaceuticals), LAMIVUDINE (Camber Pharmaceuticals), LAMIVUDINE (Centaur Pharmaceuticals Private Limited), LAMIVUDINE (Cipla USA), LAMIVUDINE (Golden State Medical Supply), LAMIVUDINE (Ingenus Pharmaceuticals), LAMIVUDINE (KAISER FOUNDATION HOSPITALS), LAMIVUDINE (KAISER FOUNDATION HOSPITALS), LAMIVUDINE (Lannett Company), LAMIVUDINE (Lupin Pharmaceuticals), LAMIVUDINE (Major Pharmaceuticals), LAMIVUDINE (Marlex Pharmaceuticals), LAMIVUDINE (Mylan Pharmaceuticals), LAMIVUDINE (Mylan Pharmaceuticals), LAMIVUDINE (Prasco Laboratories), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (REMEDYREPACK), LAMIVUDINE (Rising Health), LAMIVUDINE (State of Florida DOH Central Pharmacy), LAMIVUDINE (Strides Shasun Limited)
Formula
C8H11N3O3S
Exact mass
229.0521
Mol weight
229.2562
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
 DG02859  SLC22A6 (OAT1) substrate
Remark
Same as: C07065
Therapeutic category: 6250
ATC code: J05AF05
Product: D00353<JP/US>
Product (mixture): D07507<JP/US> D08775<JP/US> D10600<JP/US> D10838<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Hepatitis B [DS:H00412]
Target
RNA-directed DNA polymerase
Metabolism
Transporter: SLC22A6 [HSA:9356]
Interaction
Drug interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF05 Lamivudine
      D00353  Lamivudine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00353  Lamivudine (JAN/USP/INN)
Antiinfectives [br08350.html]
 Antivirals
  D00353
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00353
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00353
BRITE hierarchy
Other DBs
CAS: 134678-17-4
PubChem: 7847419
ChEBI: 63577
ChEMBL: CHEMBL141
DrugBank: DB00709
PDB-CCD: 3TC[PDBj]
LigandBox: D00353
NIKKAJI: J457.051K
LinkDB All DBs
KCF data Show

ATOM        15
            1   C1y C    19.1100  -17.9200
            2   O2x O    17.9900  -17.0800
            3   C1x C    18.6900  -19.2500
            4   C1y C    16.8700  -17.9200
            5   S2x S    17.2900  -19.2500
            6   C1b C    15.6800  -17.2900
            7   O1a O    14.3500  -18.1300
            8   C8x C    20.3000  -15.8200
            9   N4y N    20.3000  -17.2200
            10  C8y C    21.4900  -17.9200
            11  N5x N    22.7500  -17.2200
            12  C8y C    22.7500  -15.8200
            13  C8x C    21.4900  -15.1200
            14  O5x O    21.4900  -19.3200
            15  N1a N    23.9400  -15.1200
BOND        16
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Down
            6     6   7 1
            7     4   5 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13    8  13 2
            14    1   9 1 #Down
            15   10  14 2
            16   12  15 1

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