KEGG   DRUG: Lamivudine
Entry
D00353                      Drug                                   

Name
Lamivudine (JAN/USP/INN);
Epivir (TN)
  Abbr
3TC
Product
  Generic
Formula
C8H11N3O3S
Exact mass
229.0521
Mol weight
229.2562
Structure
Simcomp
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
 DG03107  Anti-HIV agent
  DG01656  HIV reverse transcriptase inhibitor
Transporter substrate
 DG02859  SLC22A6 substrate
Remark
Same as: C07065
Therapeutic category: 6250
ATC code: J05AF05
Product: D00353<JP/US>
Product (mixture): D07507<JP/US> D08775<JP/US> D10600<JP/US> D10838<US> D11392<US> D11395<US> D11396<US> D11522<JP/US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Hepatitis B [DS:H00412]
Target
HBV reverse transcriptase [KO:K21037]
HIV-1 reverse transcriptase [KO:K24802]
  Pathway
ko05161  Hepatitis B
Metabolism
Transporter: SLC22A6 [HSA:9356]
Interaction
Structure map
map07044  Antiviral agents
map07053  Anti-HIV agents
Other map
map04976  Bile secretion
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF05 Lamivudine
      D00353  Lamivudine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-hepatitis B (HBV) Agents
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)
   Lamivudine
    D00353  Lamivudine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00353  Lamivudine (JAN/USP/INN)
Drug groups [BR:br08330]
 Antiviral
  DG01890  Nucleoside reverse transcriptase inhibitor (NRTI)
   D00353  Lamivudine
  DG03107  Anti-HIV agent
   DG01656  HIV reverse transcriptase inhibitor
    D00353  Lamivudine
 Transporter substrate
  DG02859  SLC22A6 substrate
   D00353  Lamivudine
Drug classes [BR:br08332]
 Antiviral
  DG03107  Anti-HIV agent
   D00353  Lamivudine
Antimicrobials [BR:br08307]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D00353  Lamivudine (JAN/USP/INN) <JP/US>
Antimicrobials abbreviations [BR:br08327]
 Antivirals
  Genome replication inhibitor
   HBV reverse transcriptase inhibitor
    D00353  Lamivudine (JAN/USP/INN)
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00353
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00353
Drug metabolizing enzymes and transporters [br08309.html]
 Drug transporters
  D00353
Other DBs
CAS: 134678-17-4
PubChem: 7847419
ChEBI: 63577
ChEMBL: CHEMBL141
DrugBank: DB00709
PDB-CCD: 3TC[PDBj]
LigandBox: D00353
NIKKAJI: J457.051K
LinkDB
KCF data

ATOM        15
            1   C1y C    19.1100  -17.9200
            2   O2x O    17.9900  -17.0800
            3   C1x C    18.6900  -19.2500
            4   C1y C    16.8700  -17.9200
            5   S2x S    17.2900  -19.2500
            6   C1b C    15.6800  -17.2900
            7   O1a O    14.3500  -18.1300
            8   C8x C    20.3000  -15.8200
            9   N4y N    20.3000  -17.2200
            10  C8y C    21.4900  -17.9200
            11  N5x N    22.7500  -17.2200
            12  C8y C    22.7500  -15.8200
            13  C8x C    21.4900  -15.1200
            14  O5x O    21.4900  -19.3200
            15  N1a N    23.9400  -15.1200
BOND        16
            1     1   2 1
            2     1   3 1
            3     2   4 1
            4     3   5 1
            5     4   6 1 #Down
            6     6   7 1
            7     4   5 1
            8     8   9 1
            9     9  10 1
            10   10  11 1
            11   11  12 2
            12   12  13 1
            13    8  13 2
            14    1   9 1 #Down
            15   10  14 2
            16   12  15 1

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