KEGG   DRUG: TemazepamHelp
Entry
D00370                      Drug                                   

Name
Temazepam (USP/INN);
Restoril (TN)
Product
  Generic
TEMAZEPAM (Actavis Pharma), TEMAZEPAM (Aidarex Pharmaceuticals LLC), TEMAZEPAM (Aidarex Pharmaceuticals LLC), TEMAZEPAM (Aidarex Pharmaceuticals LLC), TEMAZEPAM (Amneal Pharmaceuticals LLC), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Aphena Pharma Solutions - Tennessee), TEMAZEPAM (Ascend Laboratories), TEMAZEPAM (AvKARE), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Bryant Ranch Prepack), TEMAZEPAM (Cardinal Health), TEMAZEPAM (DIRECT RX), TEMAZEPAM (Direct Rx), TEMAZEPAM (DirectRX), TEMAZEPAM (DirectRX), TEMAZEPAM (GSMS), TEMAZEPAM (H.J. Harkins Company), TEMAZEPAM (KAISER FOUNDATION HOSPITALS), TEMAZEPAM (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), TEMAZEPAM (Lake Erie Medical DBA Quality Care Products LLC), TEMAZEPAM (Liberty Pharmaceuticals), TEMAZEPAM (Major Pharmaceuticals), TEMAZEPAM (McKesson Corporation), TEMAZEPAM (McKesson Packaging Services a business unit of McKesson Corporation), TEMAZEPAM (Mylan Institutional), TEMAZEPAM (Mylan Pharmaceuticals), TEMAZEPAM (NCS HealthCare of KY), TEMAZEPAM (Novel Laboratories), TEMAZEPAM (PD-Rx Pharmaceuticals), TEMAZEPAM (PD-Rx Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Preferred Pharmaceuticals), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (Proficient Rx LP), TEMAZEPAM (REMEDYREPACK), TEMAZEPAM (Rebel Distributors Corp), TEMAZEPAM (Rebel Distributors Corp), TEMAZEPAM (RxChange), TEMAZEPAM (Sandoz), TEMAZEPAM (Sun Pharmaceutical Industries), TEMAZEPAM (TYA Pharmaceuticals), TEMAZEPAM (TYA Pharmaceuticals), TEMAZEPAM (Unit Dose Services), TEMAZEPAM (Unit Dose Services), TEMAZEPAM (Unit Dose Services), TEMAZEPAM (NuCare Pharmaceuticals), TEMAZEPAM (NuCare Pharmaceuticals), TEMAZEPAM (NuCare Pharmaceuticals)
Formula
C16H13ClN2O2
Exact mass
300.0666
Mol weight
300.7396
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01835  Benzodiazepine sedative-hypnotics
 DG01567  GABA-A receptor agonist
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C07125
ATC code: N05CD07
Product: D00370<US>
Efficacy
Minor tranquilizer
Comment
Temazepam is metabolite of Diazepam.
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07032  Hypnotics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CD Benzodiazepine derivatives
     N05CD07 Temazepam
      D00370  Temazepam (USP/INN) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Temazepam
    D00370  Temazepam (USP/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00370  Temazepam (USP/INN) <US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00370
BRITE hierarchy
Other DBs
CAS: 846-50-4
PubChem: 7847436
ChEBI: 9435
ChEMBL: CHEMBL967
DrugBank: DB00231
LigandBox: D00370
NIKKAJI: J7.138B
LinkDB All DBs
KCF data Show

ATOM        21
            1   C2y C    17.3534   -8.3394
            2   C8y C    16.5113   -7.2298
            3   C8y C    16.8465   -5.8730
            4   N1y N    18.1075   -5.2949
            5   N2x N    18.7592   -8.3646
            6   C5x C    19.3611   -5.9172
            7   C1y C    19.6476   -7.2859
            8   C8x C    15.8394   -4.9046
            9   C8x C    14.4974   -5.2927
            10  C8y C    14.1622   -6.6495
            11  C8x C    15.1693   -7.6176
            12  O1a O    20.9788   -7.7230
            13  O5x O    20.4052   -4.9828
            14  X   Cl   12.7974   -7.0439
            15  C8y C    16.7189   -9.5891
            16  C8x C    15.3173   -9.5891
            17  C8x C    14.6173  -10.8016
            18  C8x C    15.3173  -12.0140
            19  C8x C    16.7189  -12.0140
            20  C8x C    17.4189  -10.8016
            21  C1a C    18.1075   -3.8949
BOND        23
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14    6  13 2
            15   10  14 1
            16    1  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   15  20 2
            23    4  21 1

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