| Entry |
|
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| Name |
Thiothixene (USP);
Tiotixene (JAN);
Navane (TN) |
|---|
| Product |
|
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| Generic |
|
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| Formula |
C23H29N3O2S2
|
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| Exact mass |
443.1701
|
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| Mol weight |
443.63
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
|
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| Remark |
| Product (DG00895): | D00374<US> |
|
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| Efficacy |
Antipsychotic, Dopamine receptor antagonist |
|---|
| Disease |
|
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| Comment |
Thioxanthene derivative
|
|---|
| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Interaction |
|
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AF Thioxanthene derivatives
N05AF04 Tiotixene
D00374 Thiothixene (USP) <US>
USP drug classification [BR:br08302]
Antipsychotics
1st Generation/Typical
Thiothixene
D00374 Thiothixene (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG00895 Tiotixene
D00374 Thiothixene
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D00374 Thiothixene (USP) <US>
DRD3
D00374 Thiothixene (USP) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG00895 Tiotixene
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 30
1 C8x C 15.4000 -17.1500
2 C8x C 15.4000 -18.5500
3 C8x C 16.6124 -19.2500
4 C8y C 17.8249 -18.5500
5 C8y C 17.8249 -17.1500
6 C8x C 16.6124 -16.4500
7 S2x S 19.0373 -19.2500
8 C8y C 20.2497 -18.5500
9 C8y C 20.2497 -17.1500
10 C8y C 19.0373 -16.4500
11 C8x C 21.4622 -19.2500
12 C8x C 22.6746 -18.5500
13 C8y C 22.6746 -17.1500
14 C8x C 21.4622 -16.4500
15 C2b C 19.0373 -15.0500
16 C1b C 20.2518 -14.3488
17 C1b C 20.2518 -12.9488
18 N1y N 21.4473 -12.2584
19 C1x C 22.6356 -12.9445
20 C1x C 23.8480 -12.2445
21 N1y N 23.8480 -10.8445
22 C1x C 22.6597 -10.1584
23 C1x C 21.4473 -10.8584
24 C1a C 25.0744 -10.1362
25 S4a S 23.8911 -16.4477
26 N1c N 25.0886 -17.1392
27 O3c O 24.8810 -15.4577
28 O3c O 22.9011 -15.4577
29 C1a C 26.2749 -16.4543
30 C1a C 25.0887 -18.5497
BOND 33
1 1 2 1
2 2 3 2
3 3 4 1
4 4 5 2
5 5 6 1
6 1 6 2
7 4 7 1
8 7 8 1
9 8 9 2
10 9 10 1
11 5 10 1
12 8 11 1
13 11 12 2
14 12 13 1
15 13 14 2
16 9 14 1
17 10 15 2
18 15 16 1
19 16 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 18 23 1
27 21 24 1
28 13 25 1
29 25 26 1
30 25 27 2
31 25 28 2
32 26 29 1
33 26 30 1
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