KEGG   DRUG: TolazamideHelp
Entry
D00379                      Drug                                   

Name
Tolazamide (JP17/USP/INN);
Tolinase (TN)
Product
  Generic
Formula
C14H21N3O3S
Exact mass
311.1304
Mol weight
311.3998
Structure
Mol fileKCF fileDB search
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
 DG02044  Hypoglycemics
  DG01790  Sulfonamide hypoglycemic
   DG01734  Sulfonamide type sulfonylurea receptor agonist
Remark
ATC code: A10BB05
Product: D00379<US>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Type II diabetes mellitus [DS:H00409]
Comment
Sulfonylurea
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Drug interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB05 Tolazamide
      D00379  Tolazamide (JP17/USP/INN) <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Tolazamide
    D00379  Tolazamide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00379  Tolazamide (JP17/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00379  Tolazamide
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D00379
BRITE hierarchy
Other DBs
CAS: 1156-19-0
PubChem: 7847445
ChEBI: 9613
ChEMBL: CHEMBL817
DrugBank: DB00839
LigandBox: D00379
NIKKAJI: J3.663C
LinkDB All DBs
KCF data Show

ATOM        21
            1   C8y C    15.9600  -16.6600
            2   C8x C    15.9600  -18.0600
            3   C8x C    14.7700  -18.7600
            4   C8y C    13.4400  -18.0600
            5   C8x C    13.4400  -16.6600
            6   C8x C    14.7700  -15.9600
            7   C1a C    12.2500  -18.7600
            8   S4a S    17.1500  -15.9600
            9   N1b N    18.3400  -16.6600
            10  C5a C    19.5300  -15.9600
            11  N1b N    20.7200  -16.6600
            12  N1y N    21.9100  -15.9600
            13  O5a O    19.5300  -14.5600
            14  O3c O    16.1700  -14.9800
            15  O3c O    18.1300  -14.9800
            16  C1x C    21.9100  -14.5600
            17  C1x C    23.0300  -13.5800
            18  C1x C    24.3600  -13.9300
            19  C1x C    24.9900  -15.2600
            20  C1x C    24.3600  -16.5200
            21  C1x C    23.0300  -16.8000
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     1   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   10  13 2
            14    8  14 2
            15    8  15 2
            16   18  19 1
            17   16  12 1
            18   19  20 1
            19   17  18 1
            20   12  21 1
            21   16  17 1
            22   20  21 1

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