KEGG   DRUG: Tolazamide
Entry
D00379                      Drug                                   
Name
Tolazamide (JAN/USP/INN);
Tolinase (TN)
Formula
C14H21N3O3S
Exact mass
311.1304
Mol weight
311.3998
Structure
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
  DG01734  Sulfonylurea
 DG02044  Hypoglycemic agent
  DG01734  Sulfonylurea
Remark
ATC code: A10BB05
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Type II diabetes mellitus [DS:H00409]
Comment
Sulfonylurea
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB05 Tolazamide
      D00379  Tolazamide (JAN/USP/INN)
Drug groups [BR:br08330]
 Antidiabetic agent
  DG01508  Sulfonylurea receptor agonist
   DG01734  Sulfonylurea
    D00379  Tolazamide
  DG02044  Hypoglycemic agent
   DG01734  Sulfonylurea
    D00379  Tolazamide
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00379  Tolazamide (JAN/USP/INN)
Other DBs
CAS: 1156-19-0
PubChem: 7847445
ChEBI: 9613
LigandBox: D00379
NIKKAJI: J3.663C
LinkDB
KCF data

ATOM        21
            1   C8y C    15.9600  -16.6600
            2   C8x C    15.9600  -18.0600
            3   C8x C    14.7700  -18.7600
            4   C8y C    13.4400  -18.0600
            5   C8x C    13.4400  -16.6600
            6   C8x C    14.7700  -15.9600
            7   C1a C    12.2500  -18.7600
            8   S4a S    17.1500  -15.9600
            9   N1b N    18.3400  -16.6600
            10  C5a C    19.5300  -15.9600
            11  N1b N    20.7200  -16.6600
            12  N1y N    21.9100  -15.9600
            13  O5a O    19.5300  -14.5600
            14  O3c O    16.1700  -14.9800
            15  O3c O    18.1300  -14.9800
            16  C1x C    21.9100  -14.5600
            17  C1x C    23.0300  -13.5800
            18  C1x C    24.3600  -13.9300
            19  C1x C    24.9900  -15.2600
            20  C1x C    24.3600  -16.5200
            21  C1x C    23.0300  -16.8000
BOND        22
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     1   8 1
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   10  13 2
            14    8  14 2
            15    8  15 2
            16   18  19 1
            17   16  12 1
            18   19  20 1
            19   17  18 1
            20   12  21 1
            21   16  17 1
            22   20  21 1

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