KEGG   DRUG: TolbutamideHelp
Entry
D00380                      Drug                                   

Name
Tolbutamide (JP17/USP/INN);
Orinase (TN)
Product
  Generic
Formula
C12H18N2O3S
Exact mass
270.1038
Mol weight
270.3479
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01790  Sulfonamide hypoglycemic
  DG01734  Sulfonamide type sulfonylurea receptor agonist
 DG01508  Sulfonylurea receptor agonist
 DG02044  Hypoglycemics
  DG01790  Sulfonamide hypoglycemic
   DG01734  Sulfonamide type sulfonylurea receptor agonist
Remark
Same as: C07148
ATC code: A10BB03 V04CA01
Chemical structure group: DG00115
Product (DG00115): D00380<US>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Non-insulin-dependent diabetes mellitus, type II [DS:H00409]
Comment
Sulfonylurea
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Interaction
Drug interaction
Structure map
map07018  Sulfonamide derivatives - hypoglycemic agents
map07051  Antidiabetics
map07055  Sulfonamide derivatives - overview
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BB Sulfonylureas
     A10BB03 Tolbutamide
      D00380  Tolbutamide (JP17/USP/INN) <US>
 V VARIOUS
  V04 DIAGNOSTIC AGENTS
   V04C OTHER DIAGNOSTIC AGENTS
    V04CA Tests for diabetes
     V04CA01 Tolbutamide
      D00380  Tolbutamide (JP17/USP/INN) <US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Tolbutamide
    D00380  Tolbutamide (JP17/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D00380  Tolbutamide (JP17/USP/INN) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00380  Tolbutamide
  D00380  Tolbutamide tablets
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D00380
BRITE hierarchy
Other DBs
CAS: 64-77-7
PubChem: 7847446
ChEBI: 27999
ChEMBL: CHEMBL782
DrugBank: DB01124
LigandBox: D00380
NIKKAJI: J1.406K
LinkDB All DBs
KCF data Show

ATOM        18
            1   C8y C    33.3200  -19.6700
            2   S4a S    34.4400  -18.9700
            3   C8x C    32.0600  -19.0400
            4   C8x C    33.3200  -21.0700
            5   N1b N    35.9800  -19.7400
            6   O3c O    35.2800  -17.7800
            7   O3c O    33.4600  -17.7100
            8   C8x C    30.8700  -19.6700
            9   C8x C    32.1300  -21.7700
            10  C5a C    37.1000  -19.0400
            11  C8y C    30.8700  -21.0700
            12  N1b N    38.3600  -19.6700
            13  O5a O    37.1000  -17.6400
            14  C1a C    29.6800  -21.7700
            15  C1b C    39.4800  -18.9700
            16  C1b C    40.6700  -19.6000
            17  C1b C    41.7900  -18.9000
            18  C1a C    42.9100  -19.5300
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     2   7 2
            7     3   8 2
            8     4   9 1
            9     5  10 1
            10    8  11 1
            11   10  12 1
            12   10  13 2
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   16  17 1
            17   17  18 1
            18    9  11 2

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