 | | DRUG: Metronidazole | |
Entry |
|
Name |
Metronidazole (JP18/USP/INN); Flagyl (TN); Noritate (TN); Nuvessa (TN); Vandazole (TN) |
Product |
METRONIDAZOLE (B. Braun Medical), NORITATE (Bausch Health US), METRONIDAZOLE (Baxter Healthcare Corporation), METRONIDAZOLE (Baxter Healthcare Corporation), NUVESSA (Exeltis USA), METROCREAM (Galderma Laboratories), METROGEL (Galderma Laboratories), METROLOTION (Galderma Laboratories), METRONIDAZOLE (General Injectables and Vaccines), METRONIDAZOLE (Henry Schein), METRONIDAZOLE (Hospira), FLAGYL (Pfizer Laboratories Div Pfizer), VANDAZOLE (RPK Pharmaceuticals), VANDAZOLE (Upsher-Smith Laboratories) |
Generic |
METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE VAGINAL (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (A-S Medication Solutions), METRONIDAZOLE (AMICI PHARMACEUTICALS LLC), METRONIDAZOLE (AMICI PHARMACEUTICALS LLC), METRONIDAZOLE (Alembic Labs LLC), METRONIDAZOLE (Alembic Pharmaceuticals), METRONIDAZOLE (Alembic Pharmaceuticals), METRONIDAZOLE (Alembic Pharmaceuticals Limited), METRONIDAZOLE (Alembic Pharmaceuticals Limited), METRONIDAZOLE (Alembic Pharmaceuticals Limited), METRONIDAZOLE (Alembic Pharmaceuticals), METRONIDAZOLE (Aleor Dermaceuticals Limited), METRONIDAZOLE (American Health Packaging), METRONIDAZOLE (Amneal Pharmaceuticals of New York LLC), METRONIDAZOLE (Aurobindo Pharma Limited), METRONIDAZOLE (AvPAK), METRONIDAZOLE (Baxter Healthcare Corporation), METRONIDAZOLE (BluePoint Laboratories), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE VAGINAL (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Bryant Ranch Prepack), METRONIDAZOLE (Cadila Pharmaceuticals Limited), METRONIDAZOLE500 MG (Cambridge Therapeutics Technologies), METRONIDAZOLE250 MG (Cambridge Therapeutics Technologies), METRONIDAZOLE (Cardinal Health), METRONIDAZOLE (Cardinal Health), METRONIDAZOLE (Clinical Solutions Wholesale), METRONIDAZOLE (Cosette Pharmaceuticals), METRONIDAZOLE (Cosette Pharmaceuticals), METRONIDAZOLE (Cosette Pharmaceuticals), METRONIDAZOLE (Cronus Pharma LLC), METRONIDAZOLE (DIRECT RX), METRONIDAZOLE (DIRECT RX), METRONIDAZOLE (DIRECT RX), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Denton Pharma), METRONIDAZOLE (Direct Rx), METRONIDAZOLE (Direct_Rx), METRONIDAZOLE (Direct_Rx), METRONIDAZOLE (Fougera Pharmaceuticals), METRONIDAZOLE (Fougera Pharmaceuticals), METRONIDAZOLE (Fougera Pharmaceuticals), METRONIDAZOLE (GLENMARK PHARMACEUTICALS), METRONIDAZOLE (Gland Pharma Limited), METRONIDAZOLE (Golden State Medical Supply), METRONIDAZOLE (Golden State Medical Supply), METRONIDAZOLE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), METRONIDAZOLE (Hospira), METRONIDAZOLE (Lake Erie Medical DBA Quality Care Products LLC), METRONIDAZOLE (Major Pharmaceuticals), METRONIDAZOLE (Major Pharmaceuticals), ROSADAN (Medimetriks Pharmaceuticals), ROSADAN (Medimetriks Pharmaceuticals), METRONIDAZOLE (Northstar Rx LLC), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (NuCare Pharmaceuticals), METRONIDAZOLE (Oceanside Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE (PD-Rx Pharmaceuticals), METRONIDAZOLE VAGINAL (Padagis Israel Pharmaceuticals), METRONIDAZOLE (PharmPak), METRONIDAZOLE (PharmPak), METRONIDAZOLE TOPICAL GEL (Prasco Laboratories), METRONIDAZOLE (Prasco Laboratories), METRONIDAZOLE (Prasco Laboratories), METRONIDAZOLE (Prasco Laboratories), METRONIDAZOLE (Preferred Pharmaceuticals), METRONIDAZOLE (Preferred Pharmaceuticals), METRONIDAZOLE (Preferred Pharmaceuticals), METRONIDAZOLE (Preferred Pharmaceutiicals), METRONIDAZOLE (Proficient Rx LP), METRONIDAZOLE (Proficient Rx LP), METRONIDAZOLE (Proficient Rx LP), METRONIDAZOLE (Quality Care Products), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE VAGINAL (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (REMEDYREPACK), METRONIDAZOLE (RPK Pharmaceuticals), METRONIDAZOLE (RPK Pharmaceuticals), METRONIDAZOLE (RPK Pharmaceuticals), METRONIDAZOLE (RPK Pharmaceuticals), METRONIDAZOLE (RedPharm Drug), METRONIDAZOLE (RedPharm Drug), METRONIDAZOLE (RedPharm Drug), METRONIDAZOLE (RedPharm Drug), METRONIDAZOLE (RedPharm Drug), METRONIDAZOLE (Rising Pharma Holdings), METRONIDAZOLE (Rising Pharmaceuticals), METRONIDAZOLE (ST. MARY'S MEDICAL PARK PHARMACY), METRONIDAZOLE (Sagent Pharmaceuticals), METRONIDAZOLE (Sandoz), METRONIDAZOLE (Sandoz), METRONIDAZOLE (Solaris Pharma Corporation), METRONIDAZOLE (St. Mary's Medical Park Pharmacy), METRONIDAZOLE (St. Mary's Medical Park Pharmacy), METRONIDAZOLE (Strides Pharma Science Limited), METRONIDAZOLE (Sun Pharmaceutical Industries), METRONIDAZOLE (Taro Pharmaceuticals U.S.A.), METRONIDAZOLE (Taro Pharmaceuticals U.S.A.), METRONIDAZOLE (Taro Pharmaceuticals U.S.A.), METRONIDAZOLE (Teva Pharmaceuticals USA), METRONIDAZOLE (Unichem Pharmaceuticals (USA)), METRONIDAZOLE (Viona Pharmaceuticals), METRONIDAZOLE (medsource pharmaceuticals), METRONIDAZOLE TOPICAL CREAM (DirectRx) |
Formula |
C6H9N3O3
|
Exact mass |
171.0644
|
Mol weight |
171.154
|
Structure |

|
Simcomp |
|
Class |
Antiparasitic
DG01884 Imidazole antiprotozoal
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
|
Remark |
Product (DG00006): | D00409<JP/US> |
Product (mixture): | D10245<US> D10520<JP> D10774<JP> |
|
Efficacy |
Antibacterial, Antiprotozoal, DNA synthesis inhibitor |
Disease |
Bacterial vaginosis [DS: H01380] Trichomoniasis [DS: H00812] Intestinal amebiasis; amebic dysentery [DS: H00360] Bacterial endocarditis [DS: H00334] Anaerobic bacterial infections [DS: H01410] |
Comment |
Nitroimidazole derivative
|
Target |
DNA |
Metabolism |
Enzyme: CYP2A6 [HSA: 1548]
|
Interaction |
CYP inhibition: CYP2C9 [HSA: 1559]
|
Structure map |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A01 STOMATOLOGICAL PREPARATIONS
A01A STOMATOLOGICAL PREPARATIONS
A01AB Antiinfectives and antiseptics for local oral treatment
A01AB17 Metronidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
D DERMATOLOGICALS
D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
D06B CHEMOTHERAPEUTICS FOR TOPICAL USE
D06BX Other chemotherapeutics
D06BX01 Metronidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
G GENITO URINARY SYSTEM AND SEX HORMONES
G01 GYNECOLOGICAL ANTIINFECTIVES AND ANTISEPTICS
G01A ANTIINFECTIVES AND ANTISEPTICS, EXCL. COMBINATIONS WITH CORTICOSTEROIDS
G01AF Imidazole derivatives
G01AF01 Metronidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
J ANTIINFECTIVES FOR SYSTEMIC USE
J01 ANTIBACTERIALS FOR SYSTEMIC USE
J01X OTHER ANTIBACTERIALS
J01XD Imidazole derivatives
J01XD01 Metronidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P01 ANTIPROTOZOALS
P01A AGENTS AGAINST AMOEBIASIS AND OTHER PROTOZOAL DISEASES
P01AB Nitroimidazole derivatives
P01AB01 Metronidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
USP drug classification [BR:br08302]
Antibacterials
Antibacterials, Other
Metronidazole
D00409 Metronidazole (JP18/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
252 Genital organ agents
2529 Others
D00409 Metronidazole (JP18/USP/INN)
26 Epidermides
269 Miscellaneous
2699 Others
D00409 Metronidazole (JP18/USP/INN)
6 Agents against pathologic organisms and parasites
64 Parasitics (systemic)
641 Antiprotozoans
6419 Others
D00409 Metronidazole (JP18/USP/INN)
Drug groups [BR:br08330]
Antiparasitic
DG01884 Imidazole antiprotozoal
DG00006 Metronidazole
D00409 Metronidazole
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00006 Metronidazole
D00409 Metronidazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00006 Metronidazole
D00409 Metronidazole
Antimicrobials [BR:br08307]
Antibacterials
Bactericidal action
Imidazole
D00409 Metronidazole (JP18/USP/INN) <JP/US>
Antiparasitics
Agents against Amebiasis and other antiprotozoals
Nitroimidazole derivatives
D00409 Metronidazole (JP18/USP/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00409 Metronidazole
D00409 Metronidazole tablets
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00409
Drug groups [BR:br08330]
Antiparasitic
DG01884 Imidazole antiprotozoal
DG00006 Metronidazole
Metabolizing enzyme substrate
DG01638 CYP2A6 substrate
DG00006 Metronidazole
Metabolizing enzyme inhibitor
DG01643 CYP2C9 inhibitor
DG00006 Metronidazole
Antimicrobials abbreviations [BR:br08327]
Antibacterials
Bactericidal action
Imidazole
DG00006 Metronidazole
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Other DBs |
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LinkDB |
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KCF data |
ATOM 12
1 N4y N 22.2483 -16.2228
2 C8y C 21.8345 -17.4879
3 C8y C 21.1640 -15.4301
4 C1b C 23.3153 -15.5992
5 C8x C 20.5053 -17.4879
6 N2b N 22.6157 -18.5665 #+
7 N5x N 20.0855 -16.2228
8 C1a C 21.1640 -14.1009
9 C1b C 24.3995 -16.2812
10 O3a O 23.7875 -19.7150
11 O3a O 21.1582 -19.7207 #-
12 O1a O 25.6763 -15.5992
BOND 12
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 2
7 3 8 1
8 4 9 1
9 6 10 2
10 6 11 1
11 9 12 1
12 5 7 1
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