| Entry |
|
|---|
| Name |
Metolazone (JAN/USP/INN);
Zaroxolyn (TN) |
|---|
| Product |
|
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| Generic |
METOLAZONE (A-S Medication Solutions), METOLAZONE (A-S Medication Solutions), METOLAZONE (Aarkish Pharmaceuticals NJ), METOLAZONE (Advagen Pharma Limited), METOLAZONE (Alembic Pharmaceuticals Limited), METOLAZONE (Alembic Pharmaceuticals), METOLAZONE (American Health Packaging), METOLAZONE (Amici Pharma), METOLAZONE (Aphena Pharma Solutions - Tennessee), METOLAZONE (Aphena Pharma Solutions - Tennessee), METOLAZONE (Aphena Pharma Solutions - Tennessee), METOLAZONE (Aphena Pharma Solutions - Tennessee), METOLAZONE (Bayshore Pharmaceuticals LLC), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Bryant Ranch Prepack), METOLAZONE (Golden State Medical Supply), METOLAZONE (Ingenus Pharmaceuticals LLC), METOLAZONE (Major Pharmaceuticals), METOLAZONE (Marlex Pharmaceuticals), METOLAZONE (Method Pharmaceuticals), METOLAZONE (Micro Labs Limited), METOLAZONE (Mylan Institutional), METOLAZONE (Mylan Pharmaceuticals), METOLAZONE (Sandoz) |
|---|
| Formula |
C16H16ClN3O3S
|
|---|
| Exact mass |
365.0601
|
|---|
| Mol weight |
365.84
|
|---|
| Structure |
|
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| Simcomp |
|
|---|
| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
|
|---|
| Remark |
|
|---|
| Efficacy |
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor |
|---|
| Disease |
Nephrotic syndrome [DS: H01657] |
|---|
| Comment |
Sulfonamide derivative
|
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| Target |
|
|---|
| Interaction |
|
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| Structure map |
| map07017 | Sulfonamide derivatives - diuretics |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C03 DIURETICS
C03B LOW-CEILING DIURETICS, EXCL. THIAZIDES
C03BA Sulfonamides, plain
C03BA08 Metolazone
D00431 Metolazone (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Diuretics, Thiazide
Metolazone
D00431 Metolazone (JAN/USP/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG02992 Thiazide related diuretic
D00431 Metolazone
DG01690 Sulfonamide diuretic
DG02992 Thiazide related diuretic
D00431 Metolazone
Drug classes [BR:br08332]
Cardiovascular agent
DG02992 Thiazide related diuretic
D00431 Metolazone
DG03231 Antihypertensive
D00431 Metolazone
Target-based classification of drugs [BR:br08310]
Transporters
Solute carrier family
SLC12
SLC12A3 (TSC)
D00431 Metolazone (JAN/USP/INN) <US>
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 24
1 C8y C 22.2608 -17.1556
2 C8y C 22.2434 -18.5423
3 C5x C 23.4727 -16.4797
4 C8x C 21.0664 -16.4448
5 N1x N 23.4319 -19.2532
6 C8x C 21.0256 -19.2299
7 N1y N 24.6613 -17.1906
8 O5x O 23.4260 -15.0871
9 C8y C 19.7786 -17.1206
10 C1y C 24.6439 -18.5773
11 C8y C 19.8312 -18.5190
12 C8y C 25.8791 -16.5147
13 S4a S 18.6542 -16.4040
14 C1a C 25.8384 -19.2939
15 X Cl 18.6134 -19.1949
16 C8y C 25.8908 -15.1221
17 C8x C 27.0676 -17.2313
18 N1a N 17.5123 -15.6699
19 O3c O 19.4933 -15.2444
20 O3c O 17.7220 -17.7091
21 C8x C 27.1085 -14.4462
22 C1a C 24.6904 -14.4112
23 C8x C 28.2854 -16.5554
24 C8x C 28.3087 -15.1570
BOND 26
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 2
9 5 10 1
10 6 11 2
11 7 12 1
12 9 13 1
13 10 14 1
14 11 15 1
15 12 16 1
16 12 17 2
17 13 18 1
18 13 19 2
19 13 20 2
20 16 21 2
21 16 22 1
22 17 23 1
23 21 24 1
24 7 10 1
25 9 11 1
26 23 24 2
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