Homo sapiens (human): 6559
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Entry
6559 CDS
T01001
Symbol
SLC12A3, NCC, NCCT, TSC
Name
(RefSeq) solute carrier family 12 member 3
KO
K14426
solute carrier family 12 (sodium/chloride transporter), member 3
Organism
hsa
Homo sapiens (human)
Pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
Network
nt06325
Hormone/cytokine signaling
Element
N01823
FGF23-NCC/NPT signaling pathway
Disease
H00240
Gitelman syndrome
Drug target
Bendroflumethiazide:
D00650
Benzthiazide:
D00651
Benzylhydrochlorothiazide:
D01246
Chlorothiazide (
DG00268
):
D00519
<US>
D03471
<US>
Chlortalidone:
D00272
<US>
Flumethiazide:
D02453
Hydrochlorothiazide:
D00340
<JP/US>
Hydroflumethiazide:
D00654
Indapamide (
DG00269
):
D00345
<JP/US>
D06401
Mefruside:
D01877
<JP>
Methyclothiazide:
D00656
Meticrane:
D01605
Metolazone:
D00431
<US>
Penflutizide:
D01241
Polythiazide:
D00657
Quinethazone:
D00461
Trichlormethiazide:
D00658
<JP>
Tripamide:
D01895
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09152 Endocrine system
04928 Parathyroid hormone synthesis, secretion and action
6559 (SLC12A3)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
02000 Transporters [BR:
hsa02000
]
6559 (SLC12A3)
04147 Exosome [BR:
hsa04147
]
6559 (SLC12A3)
Transporters [BR:
hsa02000
]
Solute carrier family (SLC)
SLC12: Electroneutral cation-coupled Cl cotransporter
6559 (SLC12A3)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of other body fluids (saliva and urine)
6559 (SLC12A3)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
SLC12
AA_permease
AA_permease_N
AA_permease_2
Motif
Other DBs
NCBI-GeneID:
6559
NCBI-ProteinID:
NP_001119580
OMIM:
600968
HGNC:
10912
Ensembl:
ENSG00000070915
UniProt:
P55017
Structure
PDB
PDBj
LinkDB
All DBs
Position
16:56865207..56915850
Genome browser
AA seq
1021 aa
AA seq
DB search
MAELPTTETPGDATLCSGRFTISTLLSSDEPSPPAAYDSSHPSHLTHSSTFCMRTFGYNT
IDVVPTYEHYANSTQPGEPRKVRPTLADLHSFLKQEGRHLHALAFDSRPSHEMTDGLVEG
EAGTSSEKNPEEPVRFGWVKGVMIRCMLNIWGVILYLRLPWITAQAGIVLTWIIILLSVT
VTSITGLSISAISTNGKVKSGGTYFLISRSLGPELGGSIGLIFAFANAVGVAMHTVGFAE
TVRDLLQEYGAPIVDPINDIRIIAVVSVTVLLAISLAGMEWESKAQVLFFLVIMVSFANY
LVGTLIPPSEDKASKGFFSYRADIFVQNLVPDWRGPDGTFFGMFSIFFPSATGILAGANI
SGDLKDPAIAIPKGTLMAIFWTTISYLAISATIGSCVVRDASGVLNDTVTPGWGACEGLA
CSYGWNFTECTQQHSCHYGLINYYQTMSMVSGFAPLITAGIFGATLSSALACLVSAAKVF
QCLCEDQLYPLIGFFGKGYGKNKEPVRGYLLAYAIAVAFIIIAELNTIAPIISNFFLCSY
ALINFSCFHASITNSPGWRPSFQYYNKWAALFGAIISVVIMFLLTWWAALIAIGVVLFLL
LYVIYKKPEVNWGSSVQAGSYNLALSYSVGLNEVEDHIKNYRPQCLVLTGPPNFRPALVD
FVGTFTRNLSLMICGHVLIGPHKQRMPELQLIANGHTKWLNKRKIKAFYSDVIAEDLRRG
VQILMQAAGLGRMKPNILVVGFKKNWQSAHPATVEDYIGILHDAFDFNYGVCVMRMREGL
NVSKMMQAHINPVFDPAEDGKEASARVDPKALVKEEQATTIFQSEQGKKTIDIYWLFDDG
GLTLLIPYLLGRKRRWSKCKIRVFVGGQINRMDQERKAIISLLSKFRLGFHEVHILPDIN
QNPRAEHTKRFEDMIAPFRLNDGFKDEATVNEMRRDCPWKISDEEITKNRVKSLRQVRLN
EIVLDYSRDAALIVITLPIGRKGKCPSSLYMAWLETLSQDLRPPVILIRGNQENVLTFYC
Q
NT seq
3066 nt
NT seq
+upstream
nt +downstream
nt
atggcagaactgcccacaacagagacgcctggggacgccactttgtgcagcgggcgcttc
accatcagcacactgctgagcagtgatgagccctctccaccagctgcctatgacagcagc
caccccagccacctgacccacagcagcaccttctgcatgcgcacctttggctacaacacg
atcgatgtggtgcccacatatgagcactatgccaacagcacccagcctggtgagccccgg
aaggtccggcccacactggctgacctgcactccttcctcaagcaggaaggcagacacctg
catgccctggcctttgacagccggcccagccacgagatgactgatgggctggtggagggc
gaggcaggcaccagcagcgagaagaaccccgaggagccagtgcgcttcggctgggtcaag
ggggtgatgattcgttgcatgctcaacatttggggcgtgatcctctacctgcggctgccc
tggattacggcccaggcaggcatcgtcctgacctggatcatcatcctgctgtcggtcacg
gtgacctccatcacaggcctctccatctcagccatctccaccaatggcaaggtcaagtca
ggtggcacctacttcctcatctcccggagtctgggcccagagcttgggggctccatcggc
ctcattttcgctttcgccaatgccgtgggtgtggccatgcacacggtgggctttgcagag
accgtgcgggacctgctccaggagtatggggcacccatcgtggaccccattaacgacatc
cgcatcattgccgtggtctcggtcactgtgctgctggccatctccctggctggcatggag
tgggagtccaaggcccaggtgctgttcttccttgtcatcatggtctcctttgccaactat
ttagtggggacgctgatccccccatctgaggacaaggcctccaaaggcttcttcagctac
cgggcggacatttttgtccagaacttggtgcctgactggcggggtccagatggcaccttc
ttcggaatgttctccatcttcttcccctcggccacaggcatcctggcaggggccaacata
tctggtgacctcaaggaccctgctatagccatccccaaggggaccctcatggccattttc
tggacgaccatttcctacctggccatctcagccaccattggctcctgcgtggtgcgtgat
gcctctggggtcctgaatgacacagtgacccctggctggggtgcctgcgaggggctggcc
tgcagctatggctggaacttcaccgagtgcacccagcagcacagctgccactacggcctc
atcaactattaccagaccatgagcatggtgtcaggcttcgcgcccctgatcacggctggc
atcttcggggccaccctctcctctgccctggcctgccttgtctctgctgccaaagtcttc
cagtgcctttgcgaggaccagctgtacccactgatcggcttcttcggcaaaggctatggc
aagaacaaggagcccgtgcgtggctacctgctggcctacgccatcgctgtggccttcatc
atcatcgctgagctcaacaccatagcccccatcatttccaacttcttcctctgctcctat
gccctcatcaacttcagctgcttccacgcctccatcaccaactcgcctgggtggagacct
tcattccaatactacaacaagtgggcggcgctgtttggggctatcatctccgtggtcatc
atgttcctcctcacctggtgggcggccctcatcgccattggcgtggtgctcttcctcctg
ctctatgtcatctacaagaagccagaggtaaattggggctcctcggtacaggctggctcc
tacaacctggccctcagctactcggtgggcctcaatgaggtggaagaccacatcaagaac
taccgcccccagtgcctggtgctcacggggccccccaacttccgcccggccctggtggac
tttgtgggcaccttcacccggaacctcagcctgatgatctgtggccacgtgctcatcgga
ccccacaagcagaggatgcctgagctccagctcatcgccaacgggcacaccaagtggctg
aacaagaggaagatcaaggccttctactcggatgtcattgccgaggacctccgcagaggc
gtccagatcctcatgcaggccgcaggtctcgggagaatgaagcccaacattctggtggtt
gggttcaagaagaactggcagtcggctcacccggccacagtggaagactacattggcatc
ctccatgatgcctttgatttcaactatggcgtgtgtgtcatgaggatgcgggagggactc
aacgtgtccaagatgatgcaggcgcacattaaccccgtgtttgacccagcggaggacggg
aaggaagccagcgccagagtggaccccaaggccctggtgaaggaggagcaggccaccacc
atcttccagtcggagcagggcaagaagaccatagacatctactggctctttgacgatgga
ggcctcaccctcctcattccctatctccttggccgcaagaggaggtggagcaaatgcaag
atccgtgtgttcgtaggcggccagattaacaggatggaccaggagagaaaggcgatcatt
tctctgctgagcaagttccgactgggattccatgaagtccacatcctccctgacatcaac
cagaaccctcgggctgagcacaccaagaggtttgaggacatgattgcacccttccgtctg
aatgatggcttcaaggatgaggccactgtcaacgagatgcggcgggactgcccctggaag
atctcagatgaggagattacgaagaacagagtcaagtcccttcggcaggtgaggctgaat
gagattgtgctggattactcccgagacgctgctctcatcgtcatcactttgcccataggg
aggaaggggaagtgccccagctcgctgtacatggcctggctggagaccctgtcccaggac
ctcagacctccagtcatcctgatccgaggaaaccaggaaaacgtgctcaccttttactgc
cagtaa
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