KEGG   DRUG: NevirapineHelp
Entry
D00435                      Drug                                   

Name
Nevirapine (JAN/USP/INN);
Viramune (TN)
Product
  Generic
Formula
C15H14N4O
Exact mass
266.1168
Mol weight
266.2979
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG01889  Non-nucleoside reverse transcriptase inhibitor (NNRTI)
 DG01656  HIV reverse transcriptase inhibitor
Metabolizing enzyme substrate
 DG02919  CYP2B6 substrate
 DG01644  CYP2D6 substrate
 DG02913  CYP3A4 substrate
Remark
Same as: C07263
Therapeutic category: 6250
ATC code: J05AG01
Product: D00435<JP/US>
Product (mixture): D11521<US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
RNA-directed DNA polymerase
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AG Non-nucleoside reverse transcriptase inhibitors
     J05AG01 Nevirapine
      D00435  Nevirapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00435  Nevirapine (JAN/USP/INN)
Antiinfectives [br08350.html]
 Antivirals
  D00435
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00435
BRITE hierarchy
Other DBs
CAS: 129618-40-2
PubChem: 7847501
ChEBI: 63613
ChEMBL: CHEMBL57
DrugBank: DB00238
PDB-CCD: NVP[PDBj]
LigandBox: D00435
NIKKAJI: J420.601K
LinkDB All DBs
KCF data Show

ATOM        20
            1   C5x C    16.4500  -10.0100
            2   C8y C    15.6100   -8.8900
            3   C8y C    15.9600   -7.5600
            4   N1y N    17.2200   -7.0000
            5   N1x N    17.8500  -10.0100
            6   C8y C    18.4800   -7.6300
            7   C8y C    18.7600   -8.9600
            8   N5x N    14.9100   -6.5800
            9   C8x C    13.5800   -7.0000
            10  C8x C    13.2300   -8.3300
            11  C8x C    14.2800   -9.3100
            12  C8y C    20.0900   -9.3800
            13  C8x C    21.1400   -8.4700
            14  C8x C    20.8600   -7.0700
            15  N5x N    19.5300   -6.6500
            16  O5x O    15.8200  -11.2700
            17  C1y C    17.2200   -5.6000
            18  C1a C    20.3700  -10.7800
            19  C1x C    17.9200   -4.4100
            20  C1x C    16.5200   -4.4100
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 2
            19    4  17 1
            20   12  18 1
            21   19  20 1
            22   20  17 1
            23   17  19 1

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