KEGG   DRUG: NevirapineHelp
Entry
D00435                      Drug                                   

Name
Nevirapine (JAN/USP/INN);
Viramune (TN)
Product
  Generic
NEVIRAPINE (Alvogen), NEVIRAPINE EXTENDED RELEASE (Alvogen), NEVIRAPINE (Amneal Pharmaceuticals of New York), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Aurobindo Pharma Limited), NEVIRAPINE (Breckenridge Pharmaceutical), NEVIRAPINE (Camber Pharmaceuticals), NEVIRAPINE (Carlsbad Technology), NEVIRAPINE (Cipla), NEVIRAPINE (Cipla USA), NEVIRAPINE (Golden State Medical Supply), NEVIRAPINE (Macleods Pharmaceuticals Limited), NEVIRAPINE (Micro Labs Limited), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Mylan Pharmaceuticals), NEVIRAPINE (Sandoz), NEVIRAPINE (State of Florida DOH Central Pharmacy), NEVIRAPINE (State of Florida DOH Central Pharmacy), NEVIRAPINE (Strides Shasun Limited), NEVIRAPINE (West-Ward Pharmaceuticals Corp.)
Formula
C15H14N4O
Exact mass
266.1168
Mol weight
266.2979
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antiviral
 DG01889  Non-nucleoside reverse transcriptase inhibitor (NNRTI)
 DG01656  HIV reverse transcriptase inhibitor
Enzyme substrate
 DG01644  CYP2D6 substrate
Enzyme inducer
 DG01897  CYP3A5 inducer
Remark
Same as: C07263
Therapeutic category: 6250
ATC code: J05AG01
Product: D00435<JP/US>
Efficacy
Antiviral, Reverse transcriptase inhibitor
  Disease
HIV-1 infection [DS:H01563]
Target
RNA-directed DNA polymerase
Metabolism
Enzyme: CYP3A4 [HSA:1576], CYP2B6 [HSA:1555], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07053  Anti-HIV agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AG Non-nucleoside reverse transcriptase inhibitors
     J05AG01 Nevirapine
      D00435  Nevirapine (JAN/USP/INN) <JP/US>
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Non-nucleoside Reverse Transcriptase Inhibitors (NNRTI)
   Nevirapine
    D00435  Nevirapine (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 6  Agents against pathologic organisms and parasites
  62  Chemotherapeutics
   625  Antivirals
    6250  Antivirals
     D00435  Nevirapine (JAN/USP/INN)
Antiinfectives [br08350.html]
 Antivirals
  D00435
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00435
BRITE hierarchy
Other DBs
CAS: 129618-40-2
PubChem: 7847501
ChEBI: 63613
ChEMBL: CHEMBL57
DrugBank: DB00238
PDB-CCD: NVP[PDBj]
LigandBox: D00435
NIKKAJI: J420.601K
LinkDB All DBs
KCF data Show

ATOM        20
            1   C5x C    16.4500  -10.0100
            2   C8y C    15.6100   -8.8900
            3   C8y C    15.9600   -7.5600
            4   N1y N    17.2200   -7.0000
            5   N1x N    17.8500  -10.0100
            6   C8y C    18.4800   -7.6300
            7   C8y C    18.7600   -8.9600
            8   N5x N    14.9100   -6.5800
            9   C8x C    13.5800   -7.0000
            10  C8x C    13.2300   -8.3300
            11  C8x C    14.2800   -9.3100
            12  C8y C    20.0900   -9.3800
            13  C8x C    21.1400   -8.4700
            14  C8x C    20.8600   -7.0700
            15  N5x N    19.5300   -6.6500
            16  O5x O    15.8200  -11.2700
            17  C1y C    17.2200   -5.6000
            18  C1a C    20.3700  -10.7800
            19  C1x C    17.9200   -4.4100
            20  C1x C    16.5200   -4.4100
BOND        23
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17    6  15 2
            18    1  16 2
            19    4  17 1
            20   12  18 1
            21   19  20 1
            22   20  17 1
            23   17  19 1

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