KEGG   DRUG: Prochlorperazine maleate
Entry
D00479                      Drug                                   
Name
Prochlorperazine maleate (JP18/USP);
Compazine (TN)
Product
  Generic
Formula
C20H24ClN3S. (C4H4O4)2
Exact mass
605.1599
Mol weight
606.087
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
 DG03200  Antipsychotic agent
  DG01905  Phenothiazine antipsychotics
Remark
Therapeutic category: 1172
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist
  Disease
Schizophrenia [DS:H01649]
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D00479  Prochlorperazine maleate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D00479  Prochlorperazine maleate (JP18/USP)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D00479  Prochlorperazine maleate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1172  Phenothiazines
     D00479  Prochlorperazine maleate (JP18/USP)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
     D00479  Prochlorperazine maleate
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
     D00479  Prochlorperazine maleate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00479  Prochlorperazine maleate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00479  Prochlorperazine maleate
  D00479  Prochlorperazine maleate tablets
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01478  Dopamine antagonist
   DG01474  Dopamine D2-receptor antagonist
    DG00876  Prochlorperazine
  DG03200  Antipsychotic agent
   DG01905  Phenothiazine antipsychotics
    DG00876  Prochlorperazine
Other DBs
CAS: 84-02-6
PubChem: 7847545
ChEBI: 8436
LigandBox: D00479
NIKKAJI: J215.253C
LinkDB
KCF data

ATOM        41
            1   C2b C    39.0699  -17.9328
            2   C2b C    37.4396  -17.9386
            3   C6a C    39.7454  -19.1089
            4   C6a C    36.7699  -19.1205
            5   O6a O    39.0756  -20.2792
            6   O6a O    41.1078  -19.0915
            7   O6a O    35.4074  -19.1205
            8   O6a O    37.4510  -20.2909
            9   C8x C    22.1200  -19.3900
            10  C8x C    22.1200  -20.7900
            11  C8x C    23.3100  -21.4900
            12  C8y C    24.5700  -20.7900
            13  C8y C    24.5700  -19.3900
            14  C8x C    23.3100  -18.6900
            15  S2x S    25.7600  -21.4900
            16  C8y C    26.9500  -20.7900
            17  C8y C    26.9500  -19.3900
            18  N4y N    25.7600  -18.6900
            19  C8x C    28.2100  -21.4900
            20  C8x C    29.4000  -20.7900
            21  C8y C    29.4000  -19.3900
            22  C8x C    28.2100  -18.6900
            23  C1b C    25.7600  -17.2900
            24  X   Cl   30.5900  -18.6900
            25  C1b C    26.9500  -16.5900
            26  C1b C    28.1400  -17.2900
            27  N1y N    29.3300  -16.5900
            28  C1x C    30.5200  -17.2900
            29  C1x C    31.7800  -16.5900
            30  N1y N    31.7800  -15.1900
            31  C1x C    30.5900  -14.4900
            32  C1x C    29.3300  -15.1900
            33  C1a C    32.9700  -14.4900
            34  C2b C    39.0699  -17.9328
            35  C2b C    37.4396  -17.9386
            36  C6a C    36.7699  -19.1205
            37  O6a O    35.4074  -19.1205
            38  O6a O    37.4510  -20.2909
            39  C6a C    39.7454  -19.1089
            40  O6a O    39.0756  -20.2792
            41  O6a O    41.1078  -19.0915
BOND        42
            1     9  10 2
            2    10  11 1
            3    11  12 2
            4    12  13 1
            5    13  14 2
            6     9  14 1
            7    12  15 1
            8    15  16 1
            9    16  17 1
            10   17  18 1
            11   13  18 1
            12   16  19 2
            13   19  20 1
            14   20  21 2
            15   21  22 1
            16   17  22 2
            17   18  23 1
            18   21  24 1
            19   23  25 1
            20   25  26 1
            21   26  27 1
            22   27  28 1
            23   28  29 1
            24   29  30 1
            25   30  31 1
            26   31  32 1
            27   27  32 1
            28   30  33 1
            29    1   2 2
            30    1   3 1
            31    2   4 1
            32    3   5 1
            33    3   6 2
            34    4   7 1
            35    4   8 2
            36   34  35 2
            37   34  39 1
            38   35  36 1
            39   39  40 1
            40   39  41 2
            41   36  37 1
            42   36  38 2
BRACKET     1    34.1600  -21.1400   34.1600  -16.9400
            1    41.6500  -16.9400   41.6500  -21.1400
            1  2
 ORIGINAL  1    1   2   4   7   8   3   5   6
 REPEAT    1   34  35  36  37  38  39  40  41

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