KEGG   DRUG: ProchlorperazineHelp
Entry
D00493                      Drug                                   

Name
Prochlorperazine (JAN/USP/INN);
Compro (TN)
Product
  Generic
Formula
C20H24ClN3S
Exact mass
373.1379
Mol weight
373.9427
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01905  Phenothiazine antipsychotics
 DG01478  Dopamine antagonist
  DG01474  Dopamine D2-receptor antagonist
Remark
Same as: C07403
ATC code: N05AB04
Chemical structure group: DG00876
Product (DG00876): D00493<US> D00479<JP/US> D02022<JP> D02609<US>
Efficacy
Antipsychotic, Anti-emetic, Dopamine D2 receptor antagonist
Comment
Phenothiazine derivative
Target
DRD2 [HSA:1813] [KO:K04145]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04728  Dopaminergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AB Phenothiazines with piperazine structure
     N05AB04 Prochlorperazine
      D00493  Prochlorperazine (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Antiemetics
  Antiemetics, Other
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
 Antipsychotics
  1st Generation/Typical
   Prochlorperazine
    D00493  Prochlorperazine (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Dopamine
    DRD2
     D00493  Prochlorperazine (JAN/USP/INN) <US>
BRITE hierarchy
Other DBs
CAS: 58-38-8
PubChem: 7847559
ChEBI: 8435
ChEMBL: CHEMBL728
DrugBank: DB00433
PDB-CCD: P77[PDBj]
LigandBox: D00493
NIKKAJI: J1.386B
LinkDB All DBs
KCF data Show

ATOM        25
            1   C8x C     9.8700  -14.4200
            2   C8x C     9.8700  -15.8200
            3   C8x C    11.0824  -16.5200
            4   C8y C    12.2949  -15.8200
            5   C8y C    12.2949  -14.4200
            6   C8x C    11.0824  -13.7200
            7   S2x S    13.5073  -16.5200
            8   C8y C    14.7197  -15.8200
            9   C8y C    14.7197  -14.4200
            10  N4y N    13.5073  -13.7200
            11  C8x C    15.9322  -16.5200
            12  C8x C    17.1446  -15.8200
            13  C8y C    17.1446  -14.4200
            14  C8x C    15.9322  -13.7200
            15  C1b C    13.5073  -12.3200
            16  X   Cl   18.3611  -13.7177
            17  C1b C    14.7218  -11.6188
            18  C1b C    15.9183  -12.3098
            19  N1y N    17.1051  -11.6246
            20  C1x C    18.2966  -12.3128
            21  C1x C    19.5091  -11.6129
            22  N1y N    19.5093  -10.2129
            23  C1x C    18.3178   -9.5248
            24  C1x C    17.1053  -10.2246
            25  C1a C    20.7341   -9.5058
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    8  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16    9  14 2
            17   10  15 1
            18   13  16 1
            19   15  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   19  24 1
            28   22  25 1

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