| Entry |
|
|---|
| Name |
Prochlorperazine edisylate (USP);
Compazine syrup (TN) |
|---|
| Product |
|
|---|
| Generic |
PROCHLORPERAZINE EDISYLATE (Amneal Pharmaceuticals LLC), PROCHLORPERAZINE EDISYLATE (Avenacy), PROCHLORPERAZINE EDISYLATE (Baxter Healthcare Corporation), PROCHLORPERAZINE EDISYLATE (Caplin Steriles Limited), PROCHLORPERAZINE EDISYLATE (Cardinal Health 107), PROCHLORPERAZINE EDISYLATE (Civica), PROCHLORPERAZINE EDISYLATE (Cosette Pharmaceuticals), PROCHLORPERAZINE EDISYLATE (Eugia US LLC), PROCHLORPERAZINE EDISYLATE (FOSUN PHARMA USA), PROCHLORPERAZINE EDISYLATE (Gland Pharma Limited), PROCHLORPERAZINE EDISYLATE (HF Acquisition Co LLC), PROCHLORPERAZINE EDISYLATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PROCHLORPERAZINE EDISYLATE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PROCHLORPERAZINE EDISYLATE (Hikma Pharmaceuticals USA), PROCHLORPERAZINE EDISYLATE (Hikma Pharmaceuticals USA), PROCHLORPERAZINE EDISYLATE (Mylan Institutional LLC), PROCHLORPERAZINE EDISYLATE (Nexus Pharmaceuticals LLC), PROCHLORPERAZINE EDISYLATE (Sagent Pharmaceuticals), PROCHLORPERAZINE EDISYLATE (Somerset Therapeutics) |
|---|
| Formula |
C20H24ClN3S. C2H6O6S2
|
|---|
| Exact mass |
563.0985
|
|---|
| Mol weight |
564.14
|
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| Structure |
|
|---|
| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
|
|---|
| Remark |
| Product (DG00876): | D00493<US> D00479<JP/US> D02022<JP> D02609<US> |
|
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| Efficacy |
Anti-emetic, Antipsychotic, Dopamine D2 receptor antagonist |
|---|
| Comment |
Phenothiazine derivative
|
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| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
| map07029 | Antipsychotics - phenothiazines |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AB Phenothiazines with piperazine structure
N05AB04 Prochlorperazine
D02609 Prochlorperazine edisylate (USP) <US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Prochlorperazine
D02609 Prochlorperazine edisylate (USP)
Antipsychotics
1st Generation/Typical
Prochlorperazine
D02609 Prochlorperazine edisylate (USP)
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00876 Prochlorperazine
D02609 Prochlorperazine edisylate
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00876 Prochlorperazine
D02609 Prochlorperazine edisylate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D02609 Prochlorperazine edisylate (USP) <US>
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00876 Prochlorperazine
DG03200 Antipsychotic agent
DG01905 Phenothiazine antipsychotics
DG00876 Prochlorperazine
|
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| Other DBs |
|
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| LinkDB |
|
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| KCF data |
ATOM 35
1 C8x C 24.0100 -14.8400
2 C8x C 24.0100 -16.2400
3 C8x C 25.2000 -16.9400
4 C8y C 26.4600 -16.2400
5 C8y C 26.4600 -14.8400
6 C8x C 25.2000 -14.1400
7 S2x S 27.6500 -16.9400
8 C8y C 28.8400 -16.2400
9 C8y C 28.8400 -14.8400
10 N4y N 27.6500 -14.1400
11 C8x C 30.1000 -16.9400
12 C8x C 31.2900 -16.2400
13 C8y C 31.2900 -14.8400
14 C8x C 30.1000 -14.1400
15 C1b C 27.6500 -12.7400
16 X Cl 32.4800 -14.1400
17 C1b C 28.8400 -12.0400
18 C1b C 30.0300 -12.7400
19 N1y N 31.2200 -12.0400
20 C1x C 32.4100 -12.7400
21 C1x C 33.6700 -12.0400
22 N1y N 33.6700 -10.6400
23 C1x C 32.4800 -9.9400
24 C1x C 31.2200 -10.6400
25 C1a C 34.8600 -9.9400
26 S4a S 37.9624 -13.5100
27 C1b C 39.1749 -14.2100
28 C1b C 40.3873 -13.5100
29 S4a S 41.5997 -14.2100
30 O1d O 36.7500 -12.8100
31 O1d O 38.6566 -12.3073
32 O1d O 37.2570 -14.7321
33 O1d O 42.8122 -14.9100
34 O1d O 42.2947 -13.0061
35 O1d O 40.8950 -15.4310
BOND 37
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 8 11 2
13 11 12 1
14 12 13 2
15 13 14 1
16 9 14 2
17 10 15 1
18 13 16 1
19 15 17 1
20 17 18 1
21 18 19 1
22 19 20 1
23 20 21 1
24 21 22 1
25 22 23 1
26 23 24 1
27 19 24 1
28 22 25 1
29 26 27 1
30 27 28 1
31 28 29 1
32 26 30 1
33 26 31 2
34 26 32 2
35 29 33 1
36 29 34 2
37 29 35 2
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