KEGG   DRUG: ZaleplonHelp
Entry
D00530                      Drug                                   

Name
Zaleplon (JAN/USAN/INN);
Sonata (TN)
Product
  Generic
ZALEPLON (A-S Medication Solutions), ZALEPLON (Aidarex Pharmaceuticals LLC), ZALEPLON (Ascend Laboratories), ZALEPLON (Aurobindo Pharma Limited), ZALEPLON (Bryant Ranch Prepack), ZALEPLON (Bryant Ranch Prepack), ZALEPLON (DIRECT RX), ZALEPLON (Dispensing Solutions), ZALEPLON (H.J. Harkins Company), ZALEPLON (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), ZALEPLON (Lake Erie Medical DBA Quality Care Products LLC), ZALEPLON (OrchidPharma), ZALEPLON (PD-Rx Pharmaceuticals), ZALEPLON (PD-Rx Pharmaceuticals), ZALEPLON (Preferred Pharmaceuticals), ZALEPLON (Preferred Pharmaceuticals), ZALEPLON (Rebel Distributors Corp), ZALEPLON (Rebel Distributors Corp), ZALEPLON (Rebel Distributors Corp), ZALEPLON (Rising Health), ZALEPLON (Teva Pharmaceuticals USA), ZALEPLON (Unichem Pharmaceuticals (USA)), ZALEPLON (Unit Dose Services), ZALEPLON (West-Ward Pharmaceuticals Corp.)
Formula
C17H15N5O
Exact mass
305.1277
Mol weight
305.3339
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01836  Non-benzodiazepine sedative-hypnotics
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Same as: C07484
ATC code: N05CF03
Product: D00530<US>
Efficacy
Sedative-hypnotic
Comment
Non-benzodiazepines
Target
GABRA1 [HSA:2554] [KO:K05175]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: AOX1 [HSA:316], CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07032  Hypnotics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05C HYPNOTICS AND SEDATIVES
    N05CF Benzodiazepine related drugs
     N05CF03 Zaleplon
      D00530  Zaleplon (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
 Sleep Disorder Agents
  GABA Receptor Modulators
   Zaleplon
    D00530  Zaleplon (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABRA1
     D00530  Zaleplon (JAN/USAN/INN) <US>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D00530
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D00530
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00530
BRITE hierarchy
Other DBs
CAS: 151319-34-5
PubChem: 7847596
ChEBI: 10102
ChEMBL: CHEMBL1521
DrugBank: DB00962
LigandBox: D00530
NIKKAJI: J575.185C
LinkDB All DBs
KCF data Show

ATOM        23
            1   N4y N    21.5593  -17.9656
            2   C8y C    20.3721  -17.2521
            3   C8y C    21.5593  -19.3283
            4   N5x N    22.8927  -17.5036
            5   C8y C    20.3721  -15.8719
            6   C8x C    19.1615  -17.9656
            7   C8y C    22.8927  -19.7726
            8   N5x N    20.3721  -20.0476
            9   C8x C    23.6998  -18.6499
            10  C8x C    21.5593  -15.1643
            11  C8x C    19.1615  -15.1643
            12  C8x C    19.1615  -19.3283
            13  C3b C    23.3721  -21.1002
            14  C8y C    21.5593  -13.7314
            15  C8x C    19.1322  -13.7899
            16  N1c N    22.7816  -13.0238
            17  C8x C    20.3721  -13.0764
            18  C5a C    22.7465  -11.6554
            19  C1b C    23.9863  -13.6905
            20  C1a C    23.9337  -10.9302
            21  O5a O    21.5183  -10.9829
            22  C1a C    25.1734  -12.9653
            23  N3a N    23.8700  -22.4000
BOND        25
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 2
            6     3   7 2
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 1
            12    7  13 1
            13   10  14 2
            14   11  15 1
            15   14  16 1
            16   14  17 1
            17   16  18 1
            18   16  19 1
            19   18  20 1
            20   18  21 2
            21   19  22 1
            22    7   9 1
            23    8  12 2
            24   15  17 2
            25   13  23 3

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