KEGG   DRUG: Propofol
Entry
D00549                      Drug                                   
Name
Propofol (JAN/USP/INN);
Diprivan (TN)
Product
DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA), DIPRIVAN (Fresenius Kabi USA)
  Generic
PROPOFOL (A-S Medication Solutions), PROPOFOL (Actavis Pharma), PROPOFOL (Civica), PROPOFOL (Civica), PROPOFOL (General Injectables & Vaccines), PROPOFOL (General Injectables and Vaccines), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (HF Acquisition Co LLC), PROPOFOL (Henry Schein), PROPOFOL (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), PROPOFOL (Hikma Pharmaceuticals USA), PROPOFOL (Hospira), PROPOFOL (NorthStar Rx LLC), PROPOFOL (Pfizer Laboratories Div Pfizer), PROPOFOL (REMEDYREPACK), PROPOFOL (Sagent Pharmaceuticals), PROPOFOL INJECTABLE EMULSION (Dr. Reddy's Laboratories)
Formula
C12H18O
Exact mass
178.1358
Mol weight
178.2707
Structure
Simcomp
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG02030  Anesthetics
  DG02027  General anesthetics
Remark
Same as: C07523
Therapeutic category: 1119
ATC code: N01AX10
Chemical structure group: DG00797
Product (DG00797): D00549<JP/US>
Efficacy
Anesthetic (intravenous), GABA-A receptor agonist
Comment
Isopropylphenol derivative
Target
GABR [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Interaction
Structure map
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N01 ANESTHETICS
   N01A ANESTHETICS, GENERAL
    N01AX Other general anesthetics
     N01AX10 Propofol
      D00549  Propofol (JAN/USP/INN) <JP/US>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   111  General anesthetics
    1119  Others
     D00549  Propofol (JAN/USP/INN)
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   DG00797  Propofol
    D00549  Propofol
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00797  Propofol
     D00549  Propofol
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D00549  Propofol (JAN/USP/INN) <JP/US>
Prodrugs [br08324.html]
 D00549
Drug groups [BR:br08330]
 Neuropsychiatric agent
  DG01567  GABA-A receptor agonist
   DG00797  Propofol
  DG02030  Anesthetics
   DG02027  General anesthetics
    DG00797  Propofol
Other DBs
CAS: 2078-54-8
PubChem: 7847615
ChEBI: 44915
PDB-CCD: PFL[PDBj]
LigandBox: D00549
NIKKAJI: J102.606B
LinkDB
KCF data

ATOM        13
            1   C8y C    24.1226  -18.3979
            2   C8y C    25.3400  -17.6989
            3   C1c C    22.9112  -17.6989
            4   C8x C    24.1226  -19.7958
            5   C8y C    26.5514  -18.3979
            6   O1a O    25.3457  -16.3010
            7   C1a C    22.9112  -16.3010
            8   C1a C    21.6996  -18.3979
            9   C8x C    25.3400  -20.5005
            10  C1c C    27.7688  -17.6989
            11  C8x C    26.5514  -19.7958
            12  C1a C    28.9804  -18.3979
            13  C1a C    27.7688  -16.3010
BOND        13
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 2
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1
            11   10  12 1
            12   10  13 1
            13    9  11 2

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