KEGG   DRUG: MethyclothiazideHelp
Entry
D00656                      Drug                                   

Name
Methyclothiazide (JAN/USP/INN);
Enduron (TN)
Product
  Generic
Formula
C9H11Cl2N3O4S2
Exact mass
358.9568
Mol weight
360.2373
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Cardiovascular agent
 DG01690  Sulfonamide diuretic
  DG01749  Thiazide diuretic
Remark
Same as: C07765
ATC code: C03AA08
Product: D00656<US>
Efficacy
Antihypertensive, Diuretic, Na+-Cl- symport inhibitor
  Disease
Hypertension [DS:H01633]
Comment
Thiazides
Target
SLC12A3 (TSC) [HSA:6559] [KO:K14426]
SLC12A1 (NKCC2) [HSA:6557] [KO:K14425]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C03 DIURETICS
   C03A LOW-CEILING DIURETICS, THIAZIDES
    C03AA Thiazides, plain
     C03AA08 Methyclothiazide
      D00656  Methyclothiazide (JAN/USP/INN) <US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Diuretics, Thiazide
   Methyclothiazide
    D00656  Methyclothiazide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC12
    SLC12A1 (NKCC2)
     D00656  Methyclothiazide (JAN/USP/INN) <US>
    SLC12A3 (TSC)
     D00656  Methyclothiazide (JAN/USP/INN) <US>
BRITE hierarchy
Other DBs
CAS: 135-07-9
PubChem: 7847722
ChEBI: 6847
ChEMBL: CHEMBL1577
DrugBank: DB00232
LigandBox: D00656
NIKKAJI: J5.603K
LinkDB All DBs
KCF data Show

ATOM        20
            1   C8y C    25.7021  -20.2574
            2   C8y C    25.7079  -18.8595
            3   N1x N    24.5022  -20.9563
            4   C8x C    26.9135  -20.9622
            5   C8x C    26.9252  -18.1606
            6   S2x S    24.5022  -18.1548
            7   C1y C    23.2849  -20.2574
            8   C8y C    28.1308  -20.2690
            9   C8y C    28.1367  -18.8654
            10  N1y N    23.2849  -18.8595
            11  O3c O    23.4947  -17.1531
            12  O3c O    25.7021  -17.4500
            13  C1b C    22.0735  -20.9563
            14  X   Cl   29.3307  -20.9622
            15  S4a S    29.3365  -18.1665
            16  C1a C    22.0678  -18.1548
            17  X   Cl   20.8621  -20.2574
            18  N1a N    30.5479  -17.4616
            19  O3c O    28.6448  -16.9792
            20  O3c O    30.0541  -19.3982
BOND        21
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     4   8 2
            8     5   9 2
            9     6  10 1
            10    6  11 2
            11    6  12 2
            12    7  13 1
            13    8  14 1
            14    9  15 1
            15   10  16 1
            16   13  17 1
            17   15  18 1
            18    7  10 1
            19    8   9 1
            20   15  19 2
            21   15  20 2

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