| Entry |
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| Name |
Ranitidine hydrochloride (JP18/USP);
Zantac (TN) |
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| Product |
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| Generic |
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| Formula |
C13H22N4O3S. HCl
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| Exact mass |
350.1179
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| Mol weight |
350.87
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| Structure |
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| Simcomp |
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| Class |
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
Transporter substrate
DG02854 SLC22A2 substrate
Transporter inhibitor
DG02863 SLC22A2 inhibitor
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| Remark |
| Product (DG00018): | D00673<US> |
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| Efficacy |
Anti-ulcerative, H2 receptor antagonist |
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| Disease |
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| Target |
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
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| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565], CYP3A [HSA: 1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA: 6582]
|
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| Structure map |
| map07227 | Histamine H2/H3 receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A02 DRUGS FOR ACID RELATED DISORDERS
A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
A02BA H2-receptor antagonists
A02BA02 Ranitidine
D00673 Ranitidine hydrochloride (JP18/USP) <US>
USP drug classification [BR:br08302]
Gastrointestinal Agents
Histamine2 (H2) Receptor Antagonists
Ranitidine
D00673 Ranitidine hydrochloride (JP18/USP)
Classification of Japanese OTC drugs [BR:br08313]
Agents for digestive organs
09 Histamine H2 receptor blocker containing drugs
D00673 Ranitidine hydrochloride (JP18/USP)
Risk category of Japanese OTC drugs [BR:br08312]
First-class OTC drugs
Inorganic and organic chemicals
Ranitidine
D00673 Ranitidine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00018 Ranitidine
D00673 Ranitidine hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00018 Ranitidine
D00673 Ranitidine hydrochloride
DG02852 CYP3A/CYP3A4 inhibitor
DG00018 Ranitidine
D00673 Ranitidine hydrochloride
Transporter substrate
DG02854 SLC22A2 substrate
DG00018 Ranitidine
D00673 Ranitidine hydrochloride
Transporter inhibitor
DG02863 SLC22A2 inhibitor
DG00018 Ranitidine
D00673 Ranitidine hydrochloride
Drug classes [BR:br08332]
Gastrointestinal agent
DG01481 Histamine receptor H2 antagonist
D00673 Ranitidine hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Histamine
HRH2
D00673 Ranitidine hydrochloride (JP18/USP) <US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D00673 Ranitidine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00673
Drug transporters
D00673
Rx-to-OTC switch list in Japan [br08314.html]
D00673
Drug groups [BR:br08330]
Gastrointestinal agent
DG01975 Agents for peptic ulcer
DG01481 Histamine receptor H2 antagonist
DG00018 Ranitidine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00018 Ranitidine
DG02852 CYP3A/CYP3A4 inhibitor
DG00018 Ranitidine
Transporter substrate
DG02854 SLC22A2 substrate
DG00018 Ranitidine
Transporter inhibitor
DG02863 SLC22A2 inhibitor
DG00018 Ranitidine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8y C 19.1062 -21.6933
2 O2x O 20.2292 -22.5356
3 C8x C 19.5273 -20.3597
4 C1b C 17.8427 -22.3952
5 C8y C 21.3523 -21.6933
6 C8x C 20.9311 -20.3597
7 N1c N 16.6495 -21.6933
8 C1b C 22.5455 -22.3952
9 C1a C 15.4562 -22.3952
10 C1a C 16.6495 -20.2895
11 S2a S 23.7388 -21.6933
12 C1b C 25.0022 -22.3952
13 C1b C 26.1956 -21.6933
14 N1b N 27.3890 -22.3952
15 C2c C 28.5822 -21.6933
16 C2b C 29.8457 -22.3952
17 N1b N 28.5822 -20.2895
18 N2b N 31.0389 -21.6933 #+
19 C1a C 27.3890 -19.5875
20 O3a O 31.0389 -20.2895 #-
21 O3a O 32.2322 -22.3952
22 X Cl 30.1262 -25.5343
BOND 21
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 3 6 1
6 4 7 1
7 5 8 1
8 7 9 1
9 7 10 1
10 8 11 1
11 11 12 1
12 12 13 1
13 13 14 1
14 14 15 1
15 15 16 2
16 15 17 1
17 16 18 1
18 17 19 1
19 18 20 1
20 18 21 2
21 5 6 2
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