KEGG   DRUG: Ranitidine hydrochloride
Entry
D00673                      Drug                                   

Name
Ranitidine hydrochloride (JP17/USP);
Zantac (TN)
Product
  Generic
RANITIDINE (A-S Medication Solutions), RANITIDINE (Ajanta Pharma Limited), RANITIDINE (American Health Packaging), RANITIDINE (Amneal Pharmaceuticals LLC), RANITIDINE (Amneal Pharmaceuticals LLC), RANITIDINE (Amneal Pharmaceuticals of New York LLC), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aphena Pharma Solutions - Tennessee), RANITIDINE (Aurobindo Pharma Limited), RANITIDINE (AvKARE), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Bryant Ranch Prepack), RANITIDINE (Clinical Solutions Wholesale), RANITIDINE (Contract Pharmacy Services-PA), RANITIDINE (Contract Pharmacy Services-PA), RANITIDINE (Denton Pharma), RANITIDINE (Denton Pharma), RANITIDINE (Glenmark Pharmaceuticals), RANITIDINE (Golden State Medical Supply), RANITIDINE (Lake Erie Medical DBA Quality Care Products LLC), RANITIDINE (Medsource Pharmaceuticals), RANITIDINE (Mylan Institutional LLC), RANITIDINE (NCS HealthCare of KY), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCare Pharmaceuticals), RANITIDINE (NuCarePharmaceuticals), RANITIDINE (Pharmaceutical Associates), RANITIDINE (Preferred Pharmaceuticals), RANITIDINE (Preferred Pharmaceuticals), RANITIDINE (Preferred Pharmaceuticals), RANITIDINE (Preferred Pharmaceuticals), RANITIDINE (Preferred Pharmaceuticals), RANITIDINE (QPharma), RANITIDINE (Quality Care Products), RANITIDINE (REMEDYREPACK), RANITIDINE (REMEDYREPACK), RANITIDINE (REMEDYREPACK), RANITIDINE (RedPharm Drug), RANITIDINE (St. Mary's Medical Park Pharmacy), RANITIDINE (St. Mary's Medical Park Pharmacy), RANITIDINE (Strides Pharma Science Limited), RANITIDINE (Unit Dose Services), RANITIDINE (Unit Dose Services), RANITIDINE (Unit Dose Services), RANITIDINE (VKT Pharma Private Limited), RANITIDINE (Wockhardt USA LLC.), RANITIDINE (Xiromed), RANITIDINE (A-S Medication Solutions), RANITIDINE HYDROCHLORIDE (ANI Pharmaceuticals), RANITIDINE (American Health Packaging), RANITIDINE (Aurobindo Pharma Limited), RANITIDINE HYDROCHLORIDE (AvKARE), RANITIDINE HYDROCHLORIDE (Cadila Healthcare Limited), RANITIDINE HYDROCHLORIDE (Cadila Healthcare Limited), RANITIDINE HYDROCHLORIDE (Dr. Reddy's Laboratories Limited), RANITIDINE HYDROCHLORIDE (Golden State Medical Supply), RANITIDINE (Lannett Company), RANITIDINE HYDROCHLORIDE (Sandoz), RANITIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA)), RANITIDINE HYDROCHLORIDE (Zydus Pharmaceuticals (USA))
Formula
C13H22N4O3S. HCl
Exact mass
350.1179
Mol weight
350.8647
Structure
Simcomp
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Metabolizing enzyme inhibitor
 DG01645  CYP2D6 inhibitor
 DG02852  CYP3A inhibitor
Transporter substrate
 DG02854  SLC22A2 (OCT2) substrate
Transporter inhibitor
 DG02863  SLC22A2 (OCT2) inhibitor
Remark
Therapeutic category: 2325
ATC code: A02BA02
Chemical structure group: DG00018
Product (DG00018): D00673<JP/US>
Efficacy
Anti-ulcerative, H2 receptor antagonist
  Disease
Duodenal ulcer [DS:H01634]
Zollinger-Ellison syndrome [DS:H01522]
Gastric ulcer [DS:H01634]
GERD [DS:H01602]
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA:6582]
Structure map
map07038  Antiulcer drugs
map07227  Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA02 Ranitidine
      D00673  Ranitidine hydrochloride (JP17/USP) <JP/US>
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) Receptor Antagonists
   Ranitidine
    D00673  Ranitidine hydrochloride (JP17/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  23  Digestive organ agents
   232  Peptic ulcer agents
    2325  H2 blockers
     D00673  Ranitidine hydrochloride (JP17/USP)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for digestive organs
  09 Histamine H2 receptor blocker containing drugs
   D00673  Ranitidine hydrochloride (JP17/USP)
Risk category of Japanese OTC drugs [BR:br08312]
 First-class OTC drugs
  Inorganic and organic chemicals
   Ranitidine
    D00673  Ranitidine hydrochloride (JP17/USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    HRH2
     D00673  Ranitidine hydrochloride (JP17/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00673  Ranitidine hydrochloride
Drug metabolizing enzymes and transporters [br08309.html]
 Drug metabolizing enzymes
  D00673
 Drug transporters
  D00673
Rx-to-OTC switch list in Japan [br08314.html]
 D00673
Other DBs
CAS: 66357-59-3
PubChem: 7847739
ChEBI: 8777
ChEMBL: CHEMBL1092473
DrugBank: DB00863
LigandBox: D00673
NIKKAJI: J245.455F
LinkDB
KCF data

ATOM        22
            1   C8y C    19.1062  -21.6933
            2   O2x O    20.2292  -22.5356
            3   C8x C    19.5273  -20.3597
            4   C1b C    17.8427  -22.3952
            5   C8y C    21.3523  -21.6933
            6   C8x C    20.9311  -20.3597
            7   N1c N    16.6495  -21.6933
            8   C1b C    22.5455  -22.3952
            9   C1a C    15.4562  -22.3952
            10  C1a C    16.6495  -20.2895
            11  S2a S    23.7388  -21.6933
            12  C1b C    25.0022  -22.3952
            13  C1b C    26.1956  -21.6933
            14  N1b N    27.3890  -22.3952
            15  C2c C    28.5822  -21.6933
            16  C2b C    29.8457  -22.3952
            17  N1b N    28.5822  -20.2895
            18  N2b N    31.0389  -21.6933 #+
            19  C1a C    27.3890  -19.5875
            20  O3a O    31.0389  -20.2895 #-
            21  O3a O    32.2322  -22.3952
            22  X   Cl   30.1262  -25.5343
BOND        21
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20   18  21 2
            21    5   6 2

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