Entry |
|
Name |
Salmeterol xinafoate (JAN/USP); Serevent (TN) |
Product |
|
Formula |
C25H37NO4. C11H8O3
|
Exact mass |
603.3196
|
Mol weight |
603.74
|
Structure |
|
Class |
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
|
Remark |
Therapeutic category: | 2259 |
Product (DG01051): | D00687<JP/US> |
Product (mixture): | D08699<JP/US> |
|
Efficacy |
Bronchodilator, beta2-Adrenergic receptor agonist |
Disease |
Asthma [DS: H00079] Chronic obstructive pulmonary disease [DS: H01714] |
Comment |
Phenethylamine derivative
|
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
|
Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
Interaction |
|
Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
R RESPIRATORY SYSTEM
R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
R03A ADRENERGICS, INHALANTS
R03AC Selective beta-2-adrenoreceptor agonists
R03AC12 Salmeterol
D00687 Salmeterol xinafoate (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
Respiratory Tract/Pulmonary Agents
Bronchodilators, Sympathomimetic
Salmeterol
D00687 Salmeterol xinafoate (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
22 Respiratory organ agents
225 Bronchodilators
2259 Others
D00687 Salmeterol xinafoate (JAN/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
DG01051 Salmeterol
D00687 Salmeterol xinafoate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01051 Salmeterol
D00687 Salmeterol xinafoate
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRB2
D00687 Salmeterol xinafoate (JAN/USP) <JP/US>
New drug approvals in Japan [br08318.html]
Drugs with new active ingredients
D00687
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00687
Drug groups [BR:br08330]
Cardiovascular agent
DG01456 Adrenergic receptor agonist
DG01455 beta-Adrenergic receptor agonist
DG01452 beta2-Adrenergic receptor agonist
DG01051 Salmeterol
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG01051 Salmeterol
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 44
1 C8y C 17.7390 -20.3518
2 C8y C 17.7390 -18.9454
3 C8x C 18.9597 -21.0586
4 C8x C 16.5111 -21.0586
5 C8y C 18.9597 -18.2528
6 C8x C 16.5181 -18.2315
7 C8x C 20.1663 -20.3518
8 C8x C 15.2831 -20.3518
9 C8y C 20.1663 -18.9454
10 O1a O 18.9597 -16.8607
11 C8x C 15.2901 -18.9311
12 C6a C 21.3656 -18.2528
13 O6a O 22.5720 -18.9454
14 O6a O 21.3656 -16.8607
15 C8y C 10.9900 -13.7200
16 C8x C 9.8000 -14.4200
17 C8x C 10.9900 -12.3200
18 C1c C 12.1800 -14.4200
19 C8y C 8.5400 -13.7200
20 C8x C 9.8000 -11.6200
21 C1b C 13.3700 -13.7200
22 O1a O 12.1800 -15.8200
23 C8y C 8.5400 -12.3200
24 C1b C 7.3500 -14.4200
25 N1b N 14.6300 -14.4200
26 O1a O 7.3500 -11.6200
27 O1a O 6.0900 -13.7200
28 C1b C 15.8200 -13.7200
29 C1b C 17.0100 -14.4200
30 C1b C 18.2700 -13.7200
31 C1b C 19.4600 -14.4200
32 C1b C 20.6500 -13.7200
33 C1b C 21.8400 -14.4200
34 O2a O 23.1000 -13.7900
35 C1b C 24.2900 -14.4900
36 C1b C 25.4800 -13.7900
37 C1b C 26.7400 -14.4900
38 C1b C 27.9300 -13.7900
39 C8y C 29.1200 -14.4900
40 C8x C 30.3800 -13.7900
41 C8x C 29.1200 -15.8900
42 C8x C 31.5700 -14.4900
43 C8x C 30.3100 -16.5900
44 C8x C 31.5700 -15.8900
BOND 46
1 1 2 2
2 1 3 1
3 1 4 1
4 2 5 1
5 2 6 1
6 3 7 2
7 4 8 2
8 5 9 2
9 5 10 1
10 6 11 2
11 9 12 1
12 12 13 1
13 12 14 2
14 7 9 1
15 8 11 1
16 15 16 2
17 15 17 1
18 15 18 1
19 16 19 1
20 17 20 2
21 18 21 1
22 18 22 1
23 19 23 2
24 19 24 1
25 21 25 1
26 23 26 1
27 24 27 1
28 25 28 1
29 28 29 1
30 29 30 1
31 30 31 1
32 31 32 1
33 32 33 1
34 33 34 1
35 34 35 1
36 35 36 1
37 36 37 1
38 37 38 1
39 38 39 1
40 39 40 2
41 39 41 1
42 40 42 1
43 41 43 2
44 42 44 2
45 20 23 1
46 43 44 1
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