KEGG   DRUG: Valproate sodiumHelp
Entry
D00710                      Drug                                   

Name
Valproate sodium (USAN);
Sodium valproate (JP17);
Depakene (TN);
Selenica (TN)
Product
  Generic
Formula
C8H15O2. Na
Exact mass
166.097
Mol weight
166.1933
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02035  Fatty acid antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1139 1179
ATC code: N03AG01
Chemical structure group: DG00849
Product (DG00849): D00399<US> D00304<US> D00710<JP/US>
Efficacy
Anticonvulsant, Antimanic, Antimigraine, Antiepileptic
Comment
Fatty acid derivative
Target
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00710  Valproate sodium (USAN) <JP/US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Valproate
    D00710  Valproate sodium (USAN)
 Antimigraine Agents
  Prophylactic
   Valproate
    D00710  Valproate sodium (USAN)
 Bipolar Agents
  Mood Stabilizers
   Valproate
    D00710  Valproate sodium (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   113  Antiepileptics
    1139  Others
     D00710  Valproate sodium (USAN); Sodium valproate (JP17)
   117  Psychotropics
    1179  Others
     D00710  Valproate sodium (USAN); Sodium valproate (JP17)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00710  Valproate sodium (USAN) <JP/US>
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SSADH
     D00710  Valproate sodium (USAN) <JP/US>
  Transferases (EC2)
   Aminotransferase
    ABAT
     D00710  Valproate sodium (USAN) <JP/US>
  Lyases (EC4)
   Carboxy-lyases
    GAD
     D00710  Valproate sodium (USAN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D00710  Sodium valproate
  D00710  Sodium valproate tablets
  D00710  Sodium valproate syrup
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00710
 Anesthetics, analgesics and anti-inflammatory drugs
  D00710
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00710
BRITE hierarchy
Other DBs
CAS: 1069-66-5
PubChem: 7847775
ChEBI: 9925
ChEMBL: CHEMBL433
LigandBox: D00710
NIKKAJI: J7.236B
LinkDB All DBs
KCF data Show

ATOM        11
            1   C1c C    24.8619  -18.6957
            2   C1b C    24.8619  -17.3175
            3   C1b C    23.6530  -19.4139
            4   C6a C    26.0650  -19.4139
            5   C1b C    23.6472  -16.6109
            6   C1b C    22.4441  -18.6957
            7   O6a O    27.2738  -18.6957
            8   O6a O    26.0650  -20.8098 #-
            9   C1a C    22.4384  -17.3175
            10  C1a C    21.2412  -19.4139
            11  Z   Na   28.5001  -20.7280 #+
BOND        9
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 2
            7     4   8 1
            8     5   9 1
            9     6  10 1

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