Homo sapiens (human): 2572 Help Entry 2572              CDS       T01001                                  Symbol GAD2, GAD65 Name (RefSeq) glutamate decarboxylase 2   KO K01580   glutamate decarboxylase [EC:4.1.1.15] Organism hsa  Homo sapiens (human) Pathway hsa00250   Alanine, aspartate and glutamate metabolism hsa00410   beta-Alanine metabolism hsa00430   Taurine and hypotaurine metabolism hsa00650   Butanoate metabolism hsa01100   Metabolic pathways hsa04727   GABAergic synapse hsa04940   Type I diabetes mellitus Module hsa_M00027   GABA (gamma-Aminobutyrate) shunt Network nt06544  Neuroactive ligand signaling   Element N01893   Glutamine metabolism and transport in neuron Drug target Valproic acid (DG00849):  D00304<US> D00399<US> D00710<JP/US> D08667 Brite KEGG Orthology (KO) [BR:hsa00001]  09100 Metabolism   09101 Carbohydrate metabolism    00650 Butanoate metabolism     2572 (GAD2)   09105 Amino acid metabolism    00250 Alanine, aspartate and glutamate metabolism     2572 (GAD2)   09106 Metabolism of other amino acids    00410 beta-Alanine metabolism     2572 (GAD2)    00430 Taurine and hypotaurine metabolism     2572 (GAD2)  09150 Organismal Systems   09156 Nervous system    04727 GABAergic synapse     2572 (GAD2)  09160 Human Diseases   09167 Endocrine and metabolic disease    04940 Type I diabetes mellitus     2572 (GAD2) Enzymes [BR:hsa01000]  4. Lyases   4.1  Carbon-carbon lyases    4.1.1  Carboxy-lyases     4.1.1.15  glutamate decarboxylase      2572 (GAD2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Pyridoxal_deC Aminotran_5 Beta_elim_lyase Motif Other DBs NCBI-GeneID:  2572 NCBI-ProteinID:  NP_000809 OMIM:  138275 HGNC:  4093 Ensembl:  ENSG00000136750 UniProt:  Q05329 Q5VZ30 Structure PDBPDBj LinkDB All DBs Position 10:26216372..26304558 Genome browser AA seq 585 aa AA seqDB search MASPGSGFWSFGSEDGSGDSENPGTARAWCQVAQKFTGGIGNKLCALLYGDAEKPAESGG SQPPRAAARKAACACDQKPCSCSKVDVNYAFLHATDLLPACDGERPTLAFLQDVMNILLQ YVVKSFDRSTKVIDFHYPNELLQEYNWELADQPQNLEEILMHCQTTLKYAIKTGHPRYFN QLSTGLDMVGLAADWLTSTANTNMFTYEIAPVFVLLEYVTLKKMREIIGWPGGSGDGIFS PGGAISNMYAMMIARFKMFPEVKEKGMAALPRLIAFTSEHSHFSLKKGAAALGIGTDSVI LIKCDERGKMIPSDLERRILEAKQKGFVPFLVSATAGTTVYGAFDPLLAVADICKKYKIW MHVDAAWGGGLLMSRKHKWKLSGVERANSVTWNPHKMMGVPLQCSALLVREEGLMQNCNQ MHASYLFQQDKHYDLSYDTGDKALQCGRHVDVFKLWLMWRAKGTTGFEAHVDKCLELAEY LYNIIKNREGYEMVFDGKPQHTNVCFWYIPPSLRTLEDNEERMSRLSKVAPVIKARMMEY GTTMVSYQPLGDKVNFFRMVISNPAATHQDIDFLIEEIERLGQDL NT seq 1758 nt NT seq  +upstreamnt  +downstreamnt atggcatctccgggctctggcttttggtctttcgggtcggaagatggctctggggattcc gagaatcccggcacagcgcgagcctggtgccaagtggctcagaagttcacgggcggcatc ggaaacaaactgtgcgccctgctctacggagacgccgagaagccggcggagagcggcggg agccaacccccgcgggccgccgcccggaaggccgcctgcgcctgcgaccagaagccctgc agctgctccaaagtggatgtcaactacgcgtttctccatgcaacagacctgctgccggcg tgtgatggagaaaggcccactttggcgtttctgcaagatgttatgaacattttacttcag tatgtggtgaaaagtttcgatagatcaaccaaagtgattgatttccattatcctaatgag cttctccaagaatataattgggaattggcagaccaaccacaaaatttggaggaaattttg atgcattgccaaacaactctaaaatatgcaattaaaacagggcatcctagatacttcaat caactttctactggtttggatatggttggattagcagcagactggctgacatcaacagca aatactaacatgttcacctatgaaattgctccagtatttgtgcttttggaatatgtcaca ctaaagaaaatgagagaaatcattggctggccagggggctctggcgatgggatattttct cccggtggcgccatatctaacatgtatgccatgatgatcgcacgctttaagatgttccca gaagtcaaggagaaaggaatggctgctcttcccaggctcattgccttcacgtctgaacat agtcatttttctctcaagaagggagctgcagccttagggattggaacagacagcgtgatt ctgattaaatgtgatgagagagggaaaatgattccatctgatcttgaaagaaggattctt gaagccaaacagaaagggtttgttcctttcctcgtgagtgccacagctggaaccaccgtg tacggagcatttgaccccctcttagctgtcgctgacatttgcaaaaagtataagatctgg atgcatgtggatgcagcttggggtgggggattactgatgtcccgaaaacacaagtggaaa ctgagtggcgtggagagggccaactctgtgacgtggaatccacacaagatgatgggagtc cctttgcagtgctctgctctcctggttagagaagagggattgatgcagaattgcaaccaa atgcatgcctcctacctctttcagcaagataaacattatgacctgtcctatgacactgga gacaaggccttacagtgcggacgccacgttgatgtttttaaactatggctgatgtggagg gcaaaggggactaccgggtttgaagcgcatgttgataaatgtttggagttggcagagtat ttatacaacatcataaaaaaccgagaaggatatgagatggtgtttgatgggaagcctcag cacacaaatgtctgcttctggtacattcctccaagcttgcgtactctggaagacaatgaa gagagaatgagtcgcctctcgaaggtggctccagtgattaaagccagaatgatggagtat ggaaccacaatggtcagctaccaacccttgggagacaaggtcaatttcttccgcatggtc atctcaaacccagcggcaactcaccaagacattgacttcctgattgaagaaatagaacgc cttggacaagatttataa

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