KEGG   DRUG: Divalproex sodium
Entry
D00304                      Drug                                   
Name
Divalproex sodium (USP);
Valproate semisodium (INN);
Depakote (TN)
Product
DEPAKOTE (AbbVie), DEPAKOTE (AbbVie), DEPAKOTE (AbbVie)
  Generic
DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (ATLANTIC BIOLOGICALS CORP.), DIVALPROEX SODIUM (ATLANTIC BIOLOGICALS CORP.), DIVALPROEX SODIUM (Ajanta Pharma USA), DIVALPROEX SODIUM (Alembic Pharmaceuticals Limited), DIVALPROEX SODIUM (Alembic Pharmaceuticals), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (Amneal Pharmaceuticals LLC), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (AvPAK), DIVALPROEX SODIUM (Bionpharma), DIVALPROEX SODIUM (BluePoint Laboratories), DIVALPROEX SODIUM (BluePoint Laboratories), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Camber Pharmaceuticals), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Cardinal Health 107), DIVALPROEX SODIUM (Coupler LLC), DIVALPROEX SODIUM (Coupler LLC), DIVALPROEX SODIUM (Coupler LLC), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr.Reddy's Laboratories Limited), DIVALPROEX SODIUM (Lupin Pharmaceuticals), DIVALPROEX SODIUM (Lupin Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (McKesson Corporation dba SKY Packaging), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Pharmaceuticals), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NorthStar Rx LLC), DIVALPROEX SODIUM (NorthStar Rx LLC), DIVALPROEX SODIUM (Northwind Pharmaceuticals), DIVALPROEX SODIUM (NuCare Pharmaceuticals), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (Preferred Pharmaceuticals), DIVALPROEX SODIUM (Preferred Pharmaceuticals), DIVALPROEX SODIUM (Preferred Pharmaceuticals), DIVALPROEX SODIUM (Proficient Rx LP), DIVALPROEX SODIUM (Quality Care Products), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (Rising Pharma Holdings), DIVALPROEX SODIUM (Sun Pharmaceutical Industries), DIVALPROEX SODIUM (Unichem Pharmaceuticals (USA)), DIVALPROEX SODIUM (Unichem Pharmaceuticals (USA)), DIVALPROEX SODIUM (Upsher-Smith Laboratories), DIVALPROEX SODIUM (Zydus Lifesciences Limited), DIVALPROEX SODIUM (Zydus Lifesciences Limited), DIVALPROEX SODIUM (Zydus Pharmaceuticals USA), DIVALPROEX SODIUM ER (Direct_Rx)
Formula
(C8H15O2. Na)n. (C8H16O2)m
Structure
Simcomp
Class
Cardiovascular agent
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Neuropsychiatric agent
 DG03199  Antiepileptic agent
  DG02035  Fatty acid antiepileptic
Remark
ATC code: N03AG01
Chemical structure group: DG00849
Product (DG00849): D00399<US> D00304<US> D00710<JP/US>
Efficacy
Anticonvulsant
  Disease
Bipolar disorder [DS:H01653]
Comment
Fatty acid derivative
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse
Interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00304  Divalproex sodium (USP) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Anticonvulsants, Other
   Divalproex
    D00304  Divalproex sodium (USP)
 Antimigraine Agents
  Antimigraine Agents, Other
   Divalproex
    D00304  Divalproex sodium (USP)
 Bipolar Agents
  Mood Stabilizers
   Divalproex
    D00304  Divalproex sodium (USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00849  Valproic acid
     D00304  Divalproex sodium
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02035  Fatty acid antiepileptic
    DG00849  Valproic acid
     D00304  Divalproex sodium
Drug classes [BR:br08332]
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   D00304  Divalproex sodium
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00304  Divalproex sodium (USP) <US>
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SSADH
     D00304  Divalproex sodium (USP) <US>
  Transferases (EC2)
   Aminotransferase
    ABAT
     D00304  Divalproex sodium (USP) <US>
  Lyases (EC4)
   Carboxy-lyases
    GAD
     D00304  Divalproex sodium (USP) <US>
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and mutations affecting drug response
  D00304
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01575  Calcium channel blocker
   DG01573  Calcium channel T type blocker
    DG00849  Valproic acid
 Neuropsychiatric agent
  DG03199  Antiepileptic agent
   DG02035  Fatty acid antiepileptic
    DG00849  Valproic acid
Other DBs
CAS: 76584-70-8
PubChem: 7847370
ChEBI: 4667
LigandBox: D00304
LinkDB
KCF data

ATOM        21
            1   C1c C    22.5400  -21.0000
            2   C1b C    22.5400  -19.6000
            3   C1b C    21.2800  -21.7000
            4   C6a C    23.7300  -21.7000
            5   C1b C    21.2800  -18.9000
            6   C1b C    20.0900  -21.0000
            7   O6a O    23.7300  -23.1000
            8   O6a O    24.9200  -21.0000
            9   C1a C    20.0900  -19.6000
            10  C1a C    18.9000  -21.7000
            11  C1c C    33.1100  -21.2100
            12  C1b C    33.1100  -19.8100
            13  C1b C    31.8500  -21.9100
            14  C6a C    34.3000  -21.9100
            15  C1b C    31.8500  -19.1100
            16  C1b C    30.6600  -21.2100
            17  O6a O    34.3000  -23.3100 #-
            18  O6a O    35.4900  -21.2100
            19  C1a C    30.6600  -19.8100
            20  C1a C    29.4700  -21.9100
            21  Z   Na   35.9100  -23.3800 #+
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1
            10   11  12 1
            11   11  13 1
            12   11  14 1
            13   12  15 1
            14   13  16 1
            15   14  17 1
            16   14  18 2
            17   15  19 1
            18   16  20 1
BRACKET     1    16.6600  -24.1500   16.6600  -18.2700
            1    25.6900  -18.2700   25.6900  -24.1500
            1  m
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10
 REPEAT    1
            2    27.8600  -24.3600   27.8600  -18.1300
            2    37.4500  -18.1300   37.4500  -24.3600
            2  n
 ORIGINAL  2   11  12  13  14  15  16  17  18  19  20  21
 REPEAT    2

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