KEGG   DRUG: Divalproex sodiumHelp
Entry
D00304                      Drug                                   

Name
Divalproex sodium (USP);
Valproate semisodium (INN);
Depakote (TN)
Product
  Generic
DIVALPROEX SODIUM (A-S Medication Solutions), DIVALPROEX SODIUM (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUMDELAYED-RELEASE (Aidarex Pharmaceuticals LLC), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (American Health Packaging), DIVALPROEX SODIUM (Amneal Pharmaceuticals LLC), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aphena Pharma Solutions - Tennessee), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (Aurobindo Pharma Limited), DIVALPROEX SODIUM (AvPAK), DIVALPROEX SODIUM (AvPAK), DIVALPROEX SODIUM (Avera McKennan Hospital), DIVALPROEX SODIUM (BluePoint Laboratories), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Bryant Ranch Prepack), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cadila Healthcare Limited), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Cardinal Health), DIVALPROEX SODIUM (Carilion Materials Management), DIVALPROEX SODIUM (Carilion Materials Management), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (Contract Pharmacy Services-PA), DIVALPROEX SODIUM (DIRECT RX), DIVALPROEX SODIUM (DIRECT RX), DIVALPROEX SODIUM (DirectRX), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Dr. Reddy's Laboratories), DIVALPROEX SODIUM (Impax Generics), DIVALPROEX SODIUM (Lupin Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Major Pharmaceuticals), DIVALPROEX SODIUM (Medsource Pharmaceuticals), DIVALPROEX SODIUM (Mylan Institutional), DIVALPROEX SODIUM (Mylan Pharmaceuticals), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NCS HealthCare of KY), DIVALPROEX SODIUM (NorthStar Rx LLC), DIVALPROEX SODIUM (NuCare Pharmaceuticals), DIVALPROEX SODIUM (PD-Rx Pharmaceuticals), DIVALPROEX SODIUM (Par Pharmaceutical), DIVALPROEX SODIUM (Preferred Pharmaceuticals), DIVALPROEX SODIUM (Preferred Pharmaceuticals), DIVALPROEX SODIUM (Proficient Rx LP), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (REMEDYREPACK), DIVALPROEX SODIUM (Rebel Distributors Corp), DIVALPROEX SODIUM (Rising Health), DIVALPROEX SODIUM (Sandoz), DIVALPROEX SODIUM EXTENDED-RELEASE (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (State of Florida DOH Central Pharmacy), DIVALPROEX SODIUM (Sun Pharmaceutical Industries Limited), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM EXTENDED-RELEASE (TYA Pharmaceuticals), DIVALPROEX SODIUM (TYA Pharmaceuticals), DIVALPROEX SODIUM (Unichem Pharmaceuticals (USA)), DIVALPROEX SODIUM (Unit Dose Services), DIVALPROEX SODIUM (Upsher-Smith Laboratories), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (WOCKHARDT LIMITED), DIVALPROEX SODIUM (Wockhardt USA LLC.), DIVALPROEX SODIUM (Wockhardt USA LLC.), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals (USA)), DIVALPROEX SODIUM (Zydus Pharmaceuticals USA)
Formula
(C8H15O2. Na)n. (C8H16O2)m
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG02035  Fatty acid antiepileptics
Other
 DG01575  Calcium channel blocker
  DG01573  Calcium channel T type blocker
Enzyme substrate
 DG01633  CYP3A substrate
Remark
ATC code: N03AG01
Chemical structure group: DG00849
Product (DG00849): D00399<US> D00304<US> D00710<JP/US>
Efficacy
Anticonvulsant
  Disease
Bipolar disorder, manic episodes [DS:H01653]
Comment
Fatty acid derivative
Valproic acid is contraindicated in patients with known urea cycle disorders [DS:H00164 H00185 H00186 H00187 H01028 H01032]
Target
ABAT [HSA:18] [KO:K13524]
SSADH [HSA:7915] [KO:K00139]
GAD [HSA:2571 2572] [KO:K01580]
CACNA1-T [HSA:8911 8912 8913] [KO:K04856 K04855 K04854]
  Pathway
hsa04020  Calcium signaling pathway
hsa04727  GABAergic synapse
Interaction
Drug interaction
Structure map
map07033  Anticonvulsants
map07036  Calcium channel blocking drugs
map07048  Antimigraines
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N03 ANTIEPILEPTICS
   N03A ANTIEPILEPTICS
    N03AG Fatty acid derivatives
     N03AG01 Valproic acid
      D00304  Divalproex sodium (USP) <US>
USP drug classification [BR:br08302]
 Anticonvulsants
  Gamma-aminobutyric Acid (GABA) Augmenting Agents
   Divalproex
    D00304  Divalproex sodium (USP)
   Valproate
    D00304  Divalproex sodium (USP)
 Antimigraine Agents
  Prophylactic
   Divalproex
    D00304  Divalproex sodium (USP)
   Valproate
    D00304  Divalproex sodium (USP)
 Bipolar Agents
  Mood Stabilizers
   Divalproex
    D00304  Divalproex sodium (USP)
   Valproate
    D00304  Divalproex sodium (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Calcium channels
    CACNA1-T
     D00304  Divalproex sodium (USP) <US>
 Enzymes
  Oxidoreductases (EC1)
   Dehydrogenases
    SSADH
     D00304  Divalproex sodium (USP) <US>
  Transferases (EC2)
   Aminotransferase
    ABAT
     D00304  Divalproex sodium (USP) <US>
  Lyases (EC4)
   Carboxy-lyases
    GAD
     D00304  Divalproex sodium (USP) <US>
Drug classes of therapeutic agents [br08360.html]
 Neurological agents
  D00304
 Anesthetics, analgesics and anti-inflammatory drugs
  D00304
Pharmacogenomic biomarkers [br08341.html]
 Polymorphisms and germline mutations
  D00304
BRITE hierarchy
Other DBs
CAS: 76584-70-8
PubChem: 7847370
ChEBI: 4667
DrugBank: DB00510
LigandBox: D00304
LinkDB All DBs
KCF data Show

ATOM        21
            1   C1c C    22.5400  -21.0000
            2   C1b C    22.5400  -19.6000
            3   C1b C    21.2800  -21.7000
            4   C6a C    23.7300  -21.7000
            5   C1b C    21.2800  -18.9000
            6   C1b C    20.0900  -21.0000
            7   O6a O    23.7300  -23.1000
            8   O6a O    24.9200  -21.0000
            9   C1a C    20.0900  -19.6000
            10  C1a C    18.9000  -21.7000
            11  C1c C    33.1100  -21.2100
            12  C1b C    33.1100  -19.8100
            13  C1b C    31.8500  -21.9100
            14  C6a C    34.3000  -21.9100
            15  C1b C    31.8500  -19.1100
            16  C1b C    30.6600  -21.2100
            17  O6a O    34.3000  -23.3100 #-
            18  O6a O    35.4900  -21.2100
            19  C1a C    30.6600  -19.8100
            20  C1a C    29.4700  -21.9100
            21  Z   Na   35.9100  -23.3800 #+
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     4   8 2
            8     5   9 1
            9     6  10 1
            10   11  12 1
            11   11  13 1
            12   11  14 1
            13   12  15 1
            14   13  16 1
            15   14  17 1
            16   14  18 2
            17   15  19 1
            18   16  20 1
BRACKET     1    16.6600  -24.1500   16.6600  -18.2700
            1    25.6900  -18.2700   25.6900  -24.1500
            1  m
 ORIGINAL  1    1   2   3   4   5   6   7   8   9  10
 REPEAT    1
            2    27.8600  -24.3600   27.8600  -18.1300
            2    37.4500  -18.1300   37.4500  -24.3600
            2  n
 ORIGINAL  2   11  12  13  14  15  16  17  18  19  20  21
 REPEAT    2

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