| Entry |
|
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| Name |
Metoclopramide hydrochloride (USP);
Metoclopramide monohydrochloride monohydrate;
Clopra (TN);
Reglan (TN) |
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| Product |
|
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| Generic |
METOCLOPRAMIDE (A-S Medication Solutions), METOCLOPRAMIDE (ANI Pharmaceuticals), METOCLOPRAMIDE (ANI Pharmaceuticals), METOCLOPRAMIDE (ATLANTIC BIOLOGICALS CORP.), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE (Aphena Pharma Solutions - Tennessee), METOCLOPRAMIDE (AvKARE), METOCLOPRAMIDE (Avenacy), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Cardinal Health 107), METOCLOPRAMIDE (Cardinal Health 107), METOCLOPRAMIDE (Fresenius Kabi USA), METOCLOPRAMIDE (Genus Lifesciences), METOCLOPRAMIDE (HF Acquisition Co LLC), METOCLOPRAMIDE (HF Acquisition Co LLC), METOCLOPRAMIDE (Henry Schein), METOCLOPRAMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), METOCLOPRAMIDE (Hospira), METOCLOPRAMIDE (Hospira), METOCLOPRAMIDE (Medical Purchasing Solutions), METOCLOPRAMIDE (Medical Purchasing Solutions), METOCLOPRAMIDE (Mylan Institutional), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (Northwind Pharmaceuticals), METOCLOPRAMIDE (PAI Holdings), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Proficient Rx LP), METOCLOPRAMIDE (Quality Care Products LLC), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (RedPharm Drug), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Pharmaceuticals USA), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health 107), METOCLOPRAMIDE HYDROCHLORIDE (Chartwell RX), METOCLOPRAMIDE HYDROCHLORIDE (Lupin Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (VistaPharm) |
|---|
| Formula |
C14H22ClN3O2. HCl. H2O
|
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| Exact mass |
353.1273
|
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| Mol weight |
354.27
|
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| Structure |
|
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| Simcomp |
|
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| Class |
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
Gastrointestinal agent
DG01763 Propulsive
DG01489 5-HT3-receptor antagonist
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
|
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| Remark |
| Product (DG00055): | D00726<JP> D02213<JP> D05008<US> |
|
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| Efficacy |
Anti-emetic, Prokinetic, Dopamine D2 receptor antagonist |
|---|
| Disease |
Gastroesophageal reflux [DS: H01602] |
|---|
| Comment |
Benzamide derivative
|
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| Target |
|
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| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
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| Metabolism |
Enzyme: CYP2D6 [HSA: 1565]
|
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
|
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| Structure map |
| map07211 | Serotonin receptor agonists/antagonists |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
A ALIMENTARY TRACT AND METABOLISM
A03 DRUGS FOR FUNCTIONAL GASTROINTESTINAL DISORDERS
A03F PROPULSIVES
A03FA Propulsives
A03FA01 Metoclopramide
D05008 Metoclopramide hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Antiemetics
Antiemetics, Other
Metoclopramide
D05008 Metoclopramide hydrochloride (USP)
Gastrointestinal Agents
Gastrointestinal Agents, Other
Metoclopramide
D05008 Metoclopramide hydrochloride (USP)
Animal drugs in Japan [BR:br08331]
93 Agents affecting digestive organs
932 Antistomach, antidiarrhoics (including absorptives, antidiarrhoics, antibububble and preparations)
9329 Other antistomach, antidiarrhoics and preparations
D05008 Metoclopramide hydrochloride
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
Gastrointestinal agent
DG01763 Propulsive
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
DG01489 5-HT3-receptor antagonist
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00055 Metoclopramide
D05008 Metoclopramide hydrochloride
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
DRD2
D05008 Metoclopramide hydrochloride (USP) <US>
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D05008
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D05008
Drug groups [BR:br08330]
Neuropsychiatric agent
DG01478 Dopamine antagonist
DG01474 Dopamine D2-receptor antagonist
DG00055 Metoclopramide
Gastrointestinal agent
DG01763 Propulsive
DG00055 Metoclopramide
DG01489 5-HT3-receptor antagonist
DG00055 Metoclopramide
DG01762 Antiemetic
DG01783 Benzamide type antiemetic
DG00055 Metoclopramide
Metabolizing enzyme substrate
DG01644 CYP2D6 substrate
DG00055 Metoclopramide
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00055 Metoclopramide
|
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8y C 20.4459 -16.5247
2 C8y C 20.4459 -15.1244
3 C8x C 19.2556 -17.2249
4 C5a C 21.7062 -17.2249
5 C8x C 19.2556 -14.4243
6 O2a O 21.7062 -14.4243
7 C8y C 18.0654 -16.5247
8 N1b N 22.8965 -16.5247
9 O5a O 21.7062 -18.6252
10 C8y C 18.0654 -15.1244
11 C1a C 22.8965 -15.1244
12 X Cl 16.8751 -17.2249
13 C1b C 24.1567 -17.2249
14 N1a N 16.8751 -14.4243
15 C1b C 25.3470 -16.5247
16 N1c N 26.5373 -17.2249
17 C1b C 27.7976 -16.5247
18 C1b C 26.5373 -18.6252
19 C1a C 28.9878 -17.2249
20 C1a C 27.7976 -19.3254
21 X Cl 33.3900 -15.4700
22 O0 O 33.8100 -17.7800
BOND 20
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 4 8 1
8 4 9 2
9 5 10 1
10 6 11 1
11 7 12 1
12 8 13 1
13 10 14 1
14 13 15 1
15 15 16 1
16 16 17 1
17 16 18 1
18 17 19 1
19 18 20 1
20 7 10 2
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