KEGG   DRUG: メトクロプラミド塩酸塩
エントリ  
D05008                      Drug                                   

一般名   
メトクロプラミド塩酸塩;
Metoclopramide hydrochloride (USP);
Metoclopramide monohydrochloride monohydrate
米国の商品 
  後発品
METOCLOPRAMIDE (A-S Medication Solutions), METOCLOPRAMIDE (A-S Medication Solutions), METOCLOPRAMIDE (ANI Pharmaceuticals), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE (American Health Packaging), METOCLOPRAMIDE (Aphena Pharma Solutions - Tennessee), METOCLOPRAMIDE (AvKARE), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Bryant Ranch Prepack), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE (Denton Pharma), METOCLOPRAMIDE (Denton Pharma), METOCLOPRAMIDE (HF Acquisition Co LLC), METOCLOPRAMIDE (HF Acquisition Co LLC), METOCLOPRAMIDE (Hospira), METOCLOPRAMIDE (Lake Erie Medical DBA Quality Care Products LLC), METOCLOPRAMIDE (Medical Purchasing Solutions), METOCLOPRAMIDE (Medical Purchasing Solutions), METOCLOPRAMIDE (Mylan Institutional), METOCLOPRAMIDE (NCS HealthCare of KY), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (Par Pharmaceutical), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE (Proficient Rx LP), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (REMEDYREPACK), METOCLOPRAMIDE (RedPharm Drug), METOCLOPRAMIDE (RedPharm Drug), METOCLOPRAMIDE (Teva Parenteral Medicines), METOCLOPRAMIDE (Teva Pharmaceuticals USA), METOCLOPRAMIDE (Atlantic Biologicals Corps), METOCLOPRAMIDE HYDROCHLORIDE (Bryant Ranch Prepack), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health), METOCLOPRAMIDE HYDROCHLORIDE (Cardinal Health), METOCLOPRAMIDE (Cardinal Health), METOCLOPRAMIDE HYDROCHLORIDE (DIRECT RX), METOCLOPRAMIDE (Fresenius Kabi USA), METOCLOPRAMIDE (General Injectables & Vaccines), METOCLOPRAMIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (Lupin Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (NuCare Pharmaceuticals), METOCLOPRAMIDE (Pharmaceutical Associates), METOCLOPRAMIDE HYDROCHLORIDE (Preferred Pharmaceuticals), METOCLOPRAMIDE HYDROCHLORIDE (RedPharm Drug), METOCLOPRAMIDE HYDROCHLORIDE (RedPharm Drug), METOCLOPRAMIDE HYDROCHLORIDE (VistaPharm)
組成式   
C14H22ClN3O2. HCl. H2O
質量    
353.1273
分子量   
354.2726
構造式   
Simcomp   
クラス   
消化器系用薬
 DG01763  消化器運動改善薬
 DG01489  5-HT3-受容体拮抗薬
 DG01762  制吐薬
  DG01783  ベンズアミド系制吐薬
精神神経系用薬
 DG01478  ドパミン拮抗薬
  DG01474  ドパミンD2-受容体拮抗薬
代謝酵素基質薬
 DG01644  CYP2D6基質薬
代謝酵素阻害薬
 DG01645  CYP2D6阻害薬
コード   
ATCコード: A03FA01
化学構造グループ: DG00055
商品 (DG00055): D00726<JP> D02213<JP> D05008<US>
効能    
制吐薬, 消化管運動改善薬, ドパミンD2受容体拮抗薬
コメント  
ベンズアミド誘導体
ターゲット 
DRD2 [HSA:1813] [KO:K04145]
  パスウェイ
hsa04080  神経刺激性リガンドとレセプターの相互作用
hsa04728  ドーパミン作動性シナプス
代謝    
Enzyme: CYP2D6 [HSA:1565]
相互作用  
CYP inhibition: CYP2D6 [HSA:1565]

構造マップ 
map07028  抗精神病薬
map07048  抗片頭痛薬
map07211  セロトニン受容体の作動薬と拮抗薬
階層分類  
医療用医薬品のATC分類 [BR:jp08303]
 A 消化管と代謝作用
  A03 機能的胃腸疾患用薬
   A03F 運動改善薬
    A03FA 運動改善薬
     A03FA01 メトクロプラミド
      D05008  メトクロプラミド塩酸塩 <US>
医療用医薬品のUSP分類 [BR:jp08302]
 制吐薬
  制吐薬, その他
   メトクロプラミド
    D05008  メトクロプラミド塩酸塩
 胃腸薬
  胃腸薬, その他
   メトクロプラミド
    D05008  メトクロプラミド塩酸塩
動物用医薬品分類 [BR:jp08331]
 93  消化器官用薬
  932  整胃腸剤(止瘍、吸着、消泡剤を含む)
   9329  その他の整胃腸剤
    D05008  メトクロプラミド塩酸塩
ターゲットに基づく医薬品分類 [BR:jp08310]
 Gタンパク質共役受容体
  ロドプシンファミリー
   ドパミン
    DRD2
     D05008  メトクロプラミド塩酸塩 <US>
薬物代謝酵素とトランスポーター [jp08309.html]
 薬物代謝酵素
  D05008
リンク   
CAS: 54143-57-6
PubChem: 47206735
ChEBI: 6899
ChEMBL: CHEMBL1200940
DrugBank: DB01233
LigandBox: D05008
日化辞: J1.592.759C
LinkDB    

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