KEGG   DRUG: Pramoxine hydrochloride
Entry
D00739                      Drug                                   
Name
Pramoxine hydrochloride (USP);
Pramocaine hydrochloride;
Tronothane (TN)
Formula
C17H27NO3. HCl
Exact mass
329.1758
Mol weight
329.8621
Structure
Simcomp
Remark
ATC code: C05AD07 D04AB07
Chemical structure group: DG00300
Product (mixture): D11657<US>
Efficacy
Analgesic (topical), Anesthetic (topical)
Target
SCN1A [HSA:6323] [KO:K04833]
SCN2A [HSA:6326] [KO:K04834]
SCN3A [HSA:6328] [KO:K04836]
SCN4A [HSA:6329] [KO:K04837]
SCN5A [HSA:6331] [KO:K04838]
SCN8A [HSA:6334] [KO:K04840]
SCN9A [HSA:6335] [KO:K04841]
SCN10A [HSA:6336] [KO:K04842]
SCN11A [HSA:11280] [KO:K04843]
  Pathway
hsa04728  Dopaminergic synapse
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C05 VASOPROTECTIVES
   C05A AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
    C05AD Local anesthetics
     C05AD07 Pramocaine
      D00739  Pramoxine hydrochloride (USP)
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AB Anesthetics for topical use
     D04AB07 Pramocaine
      D00739  Pramoxine hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated ion channels
   Sodium channels
    SCN1A
     D00739  Pramoxine hydrochloride (USP)
    SCN2A
     D00739  Pramoxine hydrochloride (USP)
    SCN3A
     D00739  Pramoxine hydrochloride (USP)
    SCN4A
     D00739  Pramoxine hydrochloride (USP)
    SCN5A
     D00739  Pramoxine hydrochloride (USP)
    SCN8A
     D00739  Pramoxine hydrochloride (USP)
    SCN9A
     D00739  Pramoxine hydrochloride (USP)
    SCN10A
     D00739  Pramoxine hydrochloride (USP)
    SCN11A
     D00739  Pramoxine hydrochloride (USP)
Other DBs
CAS: 637-58-1
PubChem: 7847804
ChEBI: 8358
LigandBox: D00739
NIKKAJI: J327.481K
LinkDB
KCF data

ATOM        22
            1   C8y C    23.0818  -19.3550
            2   C8x C    23.0818  -20.7559
            3   C8x C    21.8676  -18.6546
            4   O2a O    24.2901  -18.6546
            5   C8x C    21.8676  -21.4621
            6   C8x C    20.6595  -19.3550
            7   C1b C    25.5041  -19.3491
            8   C8y C    20.6595  -20.7559
            9   C1b C    26.7183  -18.6487
            10  O2a O    19.4453  -21.4621
            11  C1b C    27.9266  -19.3374
            12  C1b C    18.2313  -20.7617
            13  N1y N    29.1406  -18.6429
            14  C1b C    17.0171  -21.4681
            15  C1x C    30.3489  -19.3374
            16  C1x C    29.1406  -17.2420
            17  C1b C    15.8031  -20.7734
            18  C1x C    31.5629  -18.6429
            19  C1x C    30.3489  -16.5358
            20  C1a C    14.5889  -21.4738
            21  O2x O    31.5629  -17.2420
            22  X   Cl   29.9869  -22.5373
BOND        22
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 2
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     8  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   12  14 1
            14   13  15 1
            15   13  16 1
            16   14  17 1
            17   15  18 1
            18   16  19 1
            19   17  20 1
            20   18  21 1
            21    6   8 2
            22   19  21 1

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