KEGG   Homo sapiens (human): 6335
Entry
6335              CDS       T01001                                 
Symbol
SCN9A, ETHA, FEB3B, GEFSP7, HSAN2D, NE-NA, NENA, Nav1.7, PN1, SFNP
Name
(RefSeq) sodium voltage-gated channel alpha subunit 9
  KO
K04841  voltage-gated sodium channel type IX alpha
Organism
hsa  Homo sapiens (human)
Pathway
hsa04742  Taste transduction
Disease
H00265  Hereditary sensory and autonomic neuropathy
H00771  Inherited erythromelalgia
H00772  Paroxysmal extreme pain disorder
H00774  Congenital insensitivity to pain
Drug target
Actisomide: D02762
Ajmaline: D00199
Aminobenzoic acid (DG00379): D02456 D02906 D02907
Amiodarone (DG00204): D00636<JP/US> D02910
Aprindine (DG00199): D01326<JP> D02969
Articaine (DG00805): D02991 D07468
Benzocaine: D00552<JP>
Bliretrigine: D12616
Bupivacaine (DG00801): D01450<JP/US> D07552<US>
Carbamazepine: D00252<JP/US>
Cenobamate: D11150<US>
Chloroprocaine (DG00800): D00732<US> D07678
Cibenzoline (DG00209): D01455<JP> D03492
Cinchocaine (DG00297): D00733 D02220
Cocaine (DG00808): D00110 D02182<US>
Disopyramide (DG00194): D00303<JP> D00637<JP/US>
Eleclazine: D11155
Encainide (DG00203): D03991 D07894
Eslicarbazepine (DG00848): D09215 D09612<US>
Ethyl piperidinoacetylaminobenzoate: D01519
Etidocaine (DG00804): D00737 D04095
Flecainide (DG00201): D00638<JP/US> D07962
Fosphenytoin (DG00847): D02096<US> D07595<JP> D07993
Funapide: D11156
Indecainide hydrochloride: D04521
Lacosamide: D07299<JP/US>
Lamotrigine: D00354<JP/US>
Levobupivacaine (DG00807): D01287<JP> D08116
Levosemotiadil fumarate: D09833
Lidocaine (DG00196): D00358<JP/US> D02086<JP/US> D08127<JP/US>
Lorajmine: D04774
Mephenytoin: D00375
Mepivacaine (DG00802): D00738<JP/US> D08181
Mexiletine (DG00197): D00639<JP/US> D08215
Oxcarbazepine: D00533<US>
Oxetacaine (DG00299): D01152<JP> D08311
Oxybuprocaine (DG00392): D01768<JP> D08319
Phenytoin (DG00846): D00512<JP/US> D02103<JP/US>
Pilsicainide (DG01257): D01554<JP> D08377
Pirmenol (DG01381): D01785<JP> D06517 D08394
Pramocaine (DG00300): D00739 D08407
Prilocaine (DG00803): D00553 D01243<US>
Procainamide (DG00193): D00477<JP/US> D08421
Procaine (DG00298): D00740<JP> D08422
Propafenone (DG00200): D00640<JP/US> D08435
Proxymetacaine (DG01145): D02098<US> D08448
Quinidine (DG00192): D00642<US> D00643 D02272<JP/US> D08458 D08459
Recainam (DG01421): D05708 D05709
Ropivacaine (DG00806): D04048<JP/US> D08490
Rufinamide: D05775<JP/US>
Sparteine (DG00195): D01041 D02239
Tetracaine (DG00296): D00551 D00741<US>
Tocainide (DG00198): D02088 D06172
Topiramate: D00537<JP/US>
Transcainide: D06203
Vixotrigine (DG02944): D11179 D11180
Zonisamide: D00538<JP/US>
p-Butylaminobenzoyldiethylaminoethyl hydrochloride: D01967
Brite
KEGG Orthology (KO) [BR:hsa00001]
 09150 Organismal Systems
  09157 Sensory system
   04742 Taste transduction
    6335 (SCN9A)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels [BR:hsa04040]
    6335 (SCN9A)
Ion channels [BR:hsa04040]
 Voltage-gated cation channels
  Sodium channel, voltage-gated (Nav)
   6335 (SCN9A)
SSDB
Motif
Pfam: Ion_trans Na_trans_cytopl Na_trans_assoc IQ_SCN5A_C PKD_channel GPHH IQ Lustrin_cystein
Other DBs
NCBI-GeneID: 6335
NCBI-ProteinID: NP_001352465
OMIM: 603415
HGNC: 10597
Ensembl: ENSG00000169432
UniProt: Q15858
Structure
LinkDB
Position
2:complement(166195185..166375987)
AA seq 1988 aa
MAMLPPPGPQSFVHFTKQSLALIEQRIAERKSKEPKEEKKDDDEEAPKPSSDLEAGKQLP
FIYGDIPPGMVSEPLEDLDPYYADKKTFIVLNKGKTIFRFNATPALYMLSPFSPLRRISI
KILVHSLFSMLIMCTILTNCIFMTMNNPPDWTKNVEYTFTGIYTFESLVKILARGFCVGE
FTFLRDPWNWLDFVVIVFAYLTEFVNLGNVSALRTFRVLRALKTISVIPGLKTIVGALIQ
SVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCFRNSLENNETLESIMNTLESEEDFR
KYFYYLEGSKDALLCGFSTDSGQCPEGYTCVKIGRNPDYGYTSFDTFSWAFLALFRLMTQ
DYWENLYQQTLRAAGKTYMIFFVVVIFLGSFYLINLILAVVAMAYEEQNQANIEEAKQKE
LEFQQMLDRLKKEQEEAEAIAAAAAEYTSIRRSRIMGLSESSSETSKLSSKSAKERRNRR
KKKNQKKLSSGEEKGDAEKLSKSESEDSIRRKSFHLGVEGHRRAHEKRLSTPNQSPLSIR
GSLFSARRSSRTSLFSFKGRGRDIGSETEFADDEHSIFGDNESRRGSLFVPHRPQERRSS
NISQASRSPPMLPVNGKMHSAVDCNGVVSLVDGRSALMLPNGQLLPEVIIDKATSDDSGT
TNQIHKKRRCSSYLLSEDMLNDPNLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHK
FLIWNCSPYWIKFKKCIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAIGN
LVFTGIFAAEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLVELFLADVEGLSVLRSFRLL
RVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKIN
DDCTLPRWHMNDFFHSFLIVFRVLCGEWIETMWDCMEVAGQAMCLIVYMMVMVIGNLVVL
NLFLALLLSSFSSDNLTAIEEDPDANNLQIAVTRIKKGINYVKQTLREFILKAFSKKPKI
SREIRQAEDLNTKKENYISNHTLAEMSKGHNFLKEKDKISGFGSSVDKHLMEDSDGQSFI
HNPSLTVTVPIAPGESDLENMNAEELSSDSDSEYSKVRLNRSSSSECSTVDNPLPGEGEE
AEAEPMNSDEPEACFTDGCVWRFSCCQVNIESGKGKIWWNIRKTCYKIVEHSWFESFIVL
MILLSSGALAFEDIYIERKKTIKIILEYADKIFTYIFILEMLLKWIAYGYKTYFTNAWCW
LDFLIVDVSLVTLVANTLGYSDLGPIKSLRTLRALRPLRALSRFEGMRVVVNALIGAIPS
IMNVLLVCLIFWLIFSIMGVNLFAGKFYECINTTDGSRFPASQVPNRSECFALMNVSQNV
RWKNLKVNFDNVGLGYLSLLQVATFKGWTIIMYAAVDSVNVDKQPKYEYSLYMYIYFVVF
IIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRP
GNKIQGCIFDLVTNQAFDISIMVLICLNMVTMMVEKEGQSQHMTEVLYWINVVFIILFTG
ECVLKLISLRHYYFTVGWNIFDFVVVIISIVGMFLADLIETYFVSPTLFRVIRLARIGRI
LRLVKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVKKEDGINDMFN
FETFGNSMICLFQITTSAGWDGLLAPILNSKPPDCDPKKVHPGSSVEGDCGNPSVGIFYF
VSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFS
KLSDFAAALDPPLLIAKPNKVQLIAMDLPMVSGDRIHCLDILFAFTKRVLGESGEMDSLR
SQMEERFMSANPSKVSYEPITTTLKRKQEDVSATVIQRAYRRYRLRQNVKNISSIYIKDG
DRDDDLLNKKDMAFDNVNENSSPEKTDATSSTTSPPSYDSVTKPDKEKYEQDRTEKEDKG
KDSKESKK
NT seq 5967 nt   +upstreamnt  +downstreamnt
atggcaatgttgcctcccccaggacctcagagctttgtccatttcacaaaacagtctctt
gccctcattgaacaacgcattgctgaaagaaaatcaaaggaacccaaagaagaaaagaaa
gatgatgatgaagaagccccaaagccaagcagtgacttggaagctggcaaacagctgccc
ttcatctatggggacattcctcccggcatggtgtcagagcccctggaggacttggacccc
tactatgcagacaaaaagactttcatagtattgaacaaagggaaaacaatcttccgtttc
aatgccacacctgctttatatatgctttctcctttcagtcctctaagaagaatatctatt
aagattttagtacactccttattcagcatgctcatcatgtgcactattctgacaaactgc
atatttatgaccatgaataacccaccggactggaccaaaaatgtcgagtacacttttact
ggaatatatacttttgaatcacttgtaaaaatccttgcaagaggcttctgtgtaggagaa
ttcacttttcttcgtgacccgtggaactggctggattttgtcgtcattgtttttgcgtat
ttaacagaatttgtaaacctaggcaatgtttcagctcttcgaactttcagagtattgaga
gctttgaaaactatttctgtaatcccaggcctgaagacaattgtaggggctttgatccag
tcagtgaagaagctttctgatgtcatgatcctgactgtgttctgtctgagtgtgtttgca
ctaattggactacagctgttcatgggaaacctgaagcataaatgttttcgaaattcactt
gaaaataatgaaacattagaaagcataatgaataccctagagagtgaagaagactttaga
aaatatttttattacttggaaggatccaaagatgctctcctttgtggtttcagcacagat
tcaggtcagtgtccagaggggtacacctgtgtgaaaattggcagaaaccctgattatggc
tacacgagctttgacactttcagctgggccttcttagccttgtttaggctaatgacccaa
gattactgggaaaacctttaccaacagacgctgcgtgctgctggcaaaacctacatgatc
ttctttgtcgtagtgattttcctgggctccttttatctaataaacttgatcctggctgtg
gttgccatggcatatgaagaacagaaccaggcaaacattgaagaagctaaacagaaagaa
ttagaatttcaacagatgttagaccgtcttaaaaaagagcaagaagaagctgaggcaatt
gcagcggcagcggctgaatatacaagtattaggagaagcagaattatgggcctctcagag
agttcttctgaaacatccaaactgagctctaaaagtgctaaagaaagaagaaacagaaga
aagaaaaagaatcaaaagaagctctccagtggagaggaaaagggagatgctgagaaattg
tcgaaatcagaatcagaggacagcatcagaagaaaaagtttccaccttggtgtcgaaggg
cataggcgagcacatgaaaagaggttgtctacccccaatcagtcaccactcagcattcgt
ggctccttgttttctgcaaggcgaagcagcagaacaagtctttttagtttcaaaggcaga
ggaagagatataggatctgagactgaatttgccgatgatgagcacagcatttttggagac
aatgagagcagaaggggctcactgtttgtgccccacagaccccaggagcgacgcagcagt
aacatcagccaagccagtaggtccccaccaatgctgccggtgaacgggaaaatgcacagt
gctgtggactgcaacggtgtggtctccctggttgatggacgctcagccctcatgctcccc
aatggacagcttctgccagaggtgataatagataaggcaacttctgatgacagcggcacg
accaatcaaatacacaagaaaaggcgttgtagttcctatctcctttcagaggatatgctg
aatgatcccaacctcagacagagagcaatgagtagagcaagcatattaacaaacactgtg
gaagaacttgaagagtccagacaaaaatgtccaccttggtggtacagatttgcacacaaa
ttcttgatctggaattgctctccatattggataaaattcaaaaagtgtatctattttatt
gtaatggatccttttgtagatcttgcaattaccatttgcatagttttaaacacattattt
atggctatggaacaccacccaatgactgaggaattcaaaaatgtacttgctataggaaat
ttggtctttactggaatctttgcagctgaaatggtattaaaactgattgccatggatcca
tatgagtatttccaagtaggctggaatatttttgacagccttattgtgactttaagttta
gtggagctctttctagcagatgtggaaggattgtcagttctgcgatcattcagactgctc
cgagtcttcaagttggcaaaatcctggccaacattgaacatgctgattaagatcattggt
aactcagtaggggctctaggtaacctcaccttagtgttggccatcatcgtcttcattttt
gctgtggtcggcatgcagctctttggtaagagctacaaagaatgtgtctgcaagatcaat
gatgactgtacgctcccacggtggcacatgaacgacttcttccactccttcctgattgtg
ttccgcgtgctgtgtggagagtggatagagaccatgtgggactgtatggaggtcgctggt
caagctatgtgccttattgtttacatgatggtcatggtcattggaaacctggtggtccta
aacctatttctggccttattattgagctcatttagttcagacaatcttacagcaattgaa
gaagaccctgatgcaaacaacctccagattgcagtgactagaattaaaaagggaataaat
tatgtgaaacaaaccttacgtgaatttattctaaaagcattttccaaaaagccaaagatt
tccagggagataagacaagcagaagatctgaatactaagaaggaaaactatatttctaac
catacacttgctgaaatgagcaaaggtcacaatttcctcaaggaaaaagataaaatcagt
ggttttggaagcagcgtggacaaacacttgatggaagacagtgatggtcaatcatttatt
cacaatcccagcctcacagtgacagtgccaattgcacctggggaatccgatttggaaaat
atgaatgctgaggaacttagcagtgattcggatagtgaatacagcaaagtgagattaaac
cggtcaagctcctcagagtgcagcacagttgataaccctttgcctggagaaggagaagaa
gcagaggctgaacctatgaattccgatgagccagaggcctgtttcacagatggttgtgta
tggaggttctcatgctgccaagttaacatagagtcagggaaaggaaaaatctggtggaac
atcaggaaaacctgctacaagattgttgaacacagttggtttgaaagcttcattgtcctc
atgatcctgctcagcagtggtgccctggcttttgaagatatttatattgaaaggaaaaag
accattaagattatcctggagtatgcagacaagatcttcacttacatcttcattctggaa
atgcttctaaaatggatagcatatggttataaaacatatttcaccaatgcctggtgttgg
ctggatttcctaattgttgatgtttctttggttactttagtggcaaacactcttggctac
tcagatcttggccccattaaatcccttcggacactgagagctttaagacctctaagagcc
ttatctagatttgaaggaatgagggtcgttgtgaatgcactcataggagcaattccttcc
atcatgaatgtgctacttgtgtgtcttatattctggctgatattcagcatcatgggagta
aatttgtttgctggcaagttctatgagtgtattaacaccacagatgggtcacggtttcct
gcaagtcaagttccaaatcgttccgaatgttttgcccttatgaatgttagtcaaaatgtg
cgatggaaaaacctgaaagtgaactttgataatgtcggacttggttacctatctctgctt
caagttgcaacttttaagggatggacgattattatgtatgcagcagtggattctgttaat
gtagacaagcagcccaaatatgaatatagcctctacatgtatatttattttgtcgtcttt
atcatctttgggtcattcttcactttgaacttgttcattggtgtcatcatagataatttc
aaccaacagaaaaagaagcttggaggtcaagacatctttatgacagaagaacagaagaaa
tactataatgcaatgaaaaagctggggtccaagaagccacaaaagccaattcctcgacca
gggaacaaaatccaaggatgtatatttgacctagtgacaaatcaagcctttgatattagt
atcatggttcttatctgtctcaacatggtaaccatgatggtagaaaaggagggtcaaagt
caacatatgactgaagttttatattggataaatgtggtttttataatccttttcactgga
gaatgtgtgctaaaactgatctccctcagacactactacttcactgtaggatggaatatt
tttgattttgtggttgtgattatctccattgtaggtatgtttctagctgatttgattgaa
acgtattttgtgtcccctaccctgttccgagtgatccgtcttgccaggattggccgaatc
ctacgtctagtcaaaggagcaaaggggatccgcacgctgctctttgctttgatgatgtcc
cttcctgcgttgtttaacatcggcctcctgctcttcctggtcatgttcatctacgccatc
tttggaatgtccaactttgcctatgttaaaaaggaagatggaattaatgacatgttcaat
tttgagacctttggcaacagtatgatttgcctgttccaaattacaacctctgctggctgg
gatggattgctagcacctattcttaacagtaagccacccgactgtgacccaaaaaaagtt
catcctggaagttcagttgaaggagactgtggtaacccatctgttggaatattctacttt
gttagttatatcatcatatccttcctggttgtggtgaacatgtacattgcagtcatactg
gagaattttagtgttgccactgaagaaagtactgaacctctgagtgaggatgactttgag
atgttctatgaggtttgggagaagtttgatcccgatgcgacccagtttatagagttctct
aaactctctgattttgcagctgccctggatcctcctcttctcatagcaaaacccaacaaa
gtccagctcattgccatggatctgcccatggttagtggtgaccggatccattgtcttgac
atcttatttgcttttacaaagcgtgttttgggtgagagtggggagatggattctcttcgt
tcacagatggaagaaaggttcatgtctgcaaatccttccaaagtgtcctatgaacccatc
acaaccacactaaaacggaaacaagaggatgtgtctgctactgtcattcagcgtgcttat
agacgttaccgcttaaggcaaaatgtcaaaaatatatcaagtatatacataaaagatgga
gacagagatgatgatttactcaataaaaaagatatggcttttgataatgttaatgagaac
tcaagtccagaaaaaacagatgccacttcatccaccacctctccaccttcatatgatagt
gtaacaaagccagacaaagagaaatatgaacaagacagaacagaaaaggaagacaaaggg
aaagacagcaaggaaagcaaaaaatag

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