| Entry |
|
|---|
| Name |
Nefazodone hydrochloride (USP);
Serzone (TN) |
|---|
| Product |
|
|---|
| Generic |
|
|---|
| Formula |
C25H32ClN5O2. HCl
|
|---|
| Exact mass |
505.2011
|
|---|
| Mol weight |
506.46
|
|---|
| Structure |
|
|---|
| Simcomp |
|
|---|
| Remark |
| Product (DG00953): | D00819<US> |
|
|---|
| Efficacy |
Antidepressant |
|---|
| Disease |
Major depressive disorder [DS: H01646] |
|---|
| Comment |
Phenylpiperazine derivative
|
|---|
| Target |
|
|---|
| Pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
|
|---|
| Interaction |
|
|---|
| Structure map |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06A ANTIDEPRESSANTS
N06AX Other antidepressants
N06AX06 Nefazodone
D00819 Nefazodone hydrochloride (USP) <US>
USP drug classification [BR:br08302]
Antidepressants
SSRIs/SNRIs (Selective Serotonin Reuptake Inhibitors/Serotonin and Norepinephrine Reuptake Inhibitors)
Nefazodone
D00819 Nefazodone hydrochloride (USP)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D00819 Nefazodone hydrochloride (USP) <US>
Serotonin
HTR2A
D00819 Nefazodone hydrochloride (USP) <US>
HTR2C
D00819 Nefazodone hydrochloride (USP) <US>
Pharmacogenomic biomarkers [br08341.html]
Polymorphisms and mutations affecting drug response
D00819
|
|---|
| Other DBs |
|
|---|
| LinkDB |
|
|---|
| KCF data |
ATOM 34
1 N4y N 22.2563 -18.7591
2 C8y C 22.6585 -17.4126
3 C8y C 23.4221 -19.5696
4 C1b C 21.0379 -19.4646
5 N5x N 24.0750 -17.4419
6 C1b C 21.7958 -16.2992
7 N4y N 24.5357 -18.7067
8 O5x O 23.4571 -20.9744
9 C1b C 19.8196 -18.7650
10 C1a C 22.3380 -14.9935
11 C1b C 25.6374 -19.4238
12 O2a O 18.6012 -19.4703
13 C1b C 26.7741 -18.7126
14 C8y C 17.3771 -18.7650
15 C1b C 27.9167 -19.4238
16 C8x C 16.1587 -19.4703
17 C8x C 17.3771 -17.3543
18 N1y N 29.0418 -18.6834
19 C8x C 14.9520 -18.7650
20 C8x C 16.1587 -16.6547
21 C1x C 29.0418 -17.2786
22 C1x C 30.2542 -19.3888
23 C8x C 14.9520 -17.3543
24 C1x C 30.2542 -16.5731
25 C1x C 31.4726 -18.6834
26 N1y N 31.4726 -17.2786
27 C8y C 32.6967 -16.5731
28 C8x C 32.6967 -15.1625
29 C8x C 33.9210 -17.2786
30 C8y C 33.9210 -14.4571
31 C8x C 35.1334 -16.5731
32 C8x C 35.1334 -15.1625
33 X Cl 33.9210 -13.0522
34 X Cl 34.2300 -20.5100
BOND 36
1 1 2 1
2 1 3 1
3 1 4 1
4 2 5 2
5 2 6 1
6 3 7 1
7 3 8 2
8 4 9 1
9 6 10 1
10 7 11 1
11 9 12 1
12 11 13 1
13 12 14 1
14 13 15 1
15 14 16 2
16 14 17 1
17 15 18 1
18 16 19 1
19 17 20 2
20 18 21 1
21 18 22 1
22 19 23 2
23 21 24 1
24 22 25 1
25 24 26 1
26 26 27 1
27 27 28 2
28 27 29 1
29 28 30 1
30 29 31 2
31 30 32 2
32 30 33 1
33 5 7 1
34 20 23 1
35 25 26 1
36 31 32 1
|
|---|
