| Entry |
|
|---|
| Name |
Indinavir sulfate (USP);
Crixivan (TN) |
|---|
| Formula |
C36H47N5O4. H2SO4
|
|---|
| Exact mass |
711.3302
|
|---|
| Mol weight |
711.868
|
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| Structure |
|
|---|
| Simcomp |
|
|---|
| Class |
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
|
|---|
| Remark |
|
|---|
| Efficacy |
Antiviral, HIV protease inhibitor |
|---|
| Disease |
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Metabolism |
Enzyme: CYP3A4 [HSA: 1576]
|
|---|
| Interaction |
CYP inhibition: CYP3A4 [HSA: 1576]
|
|---|
| Structure map |
|
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
J ANTIINFECTIVES FOR SYSTEMIC USE
J05 ANTIVIRALS FOR SYSTEMIC USE
J05A DIRECT ACTING ANTIVIRALS
J05AE Protease inhibitors
J05AE02 Indinavir
D00897 Indinavir sulfate (USP)
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00654 Indinavir
D00897 Indinavir sulfate
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00654 Indinavir
D00897 Indinavir sulfate
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00654 Indinavir
D00897 Indinavir sulfate
Antimicrobials [BR:br08307]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
D00897 Indinavir sulfate (USP)
New drug approvals in Europe [br08329.html]
European public assessment reports (EPAR) authorised medicine
D00897
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D00897
Drug groups [BR:br08330]
Antiviral
DG03107 Anti-HIV agent
DG01647 HIV protease inhibitor
DG00654 Indinavir
Metabolizing enzyme substrate
DG01633 CYP3A/CYP3A4 substrate
DG02913 CYP3A4 substrate
DG00654 Indinavir
Metabolizing enzyme inhibitor
DG02852 CYP3A/CYP3A4 inhibitor
DG01522 CYP3A4 inhibitor
DG00654 Indinavir
Antimicrobials abbreviations [BR:br08327]
Antivirals
Polyprotein cleavage inhibitor
HIV protease inhibitor
DG00654 Indinavir
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 50
1 C8y C 11.4820 -15.1198
2 C1y C 12.5280 -14.1436
3 C8y C 10.2268 -14.3528
4 C8x C 11.4820 -16.5145
5 C1y C 11.9701 -12.8883
6 N1b N 13.6437 -14.9106
7 C1x C 10.5754 -13.0278
8 C8x C 9.0413 -15.1198
9 C8x C 10.2268 -17.1421
10 O1a O 12.6675 -11.6331
11 C5a C 14.9687 -14.0738
12 C8x C 9.0413 -16.4448
13 C1c C 16.2239 -14.8409
14 O5a O 14.9687 -12.6791
15 C1b C 16.2239 -16.2356
16 C1b C 17.4094 -14.0738
17 C8y C 14.9687 -16.8632
18 C1c C 18.5949 -14.8409
19 C8x C 14.9684 -18.2579
20 C8x C 13.7832 -16.1659
21 C1b C 19.8501 -14.1436
22 O1a O 18.5949 -16.2356
23 C8x C 13.7832 -18.9552
24 C8x C 12.5977 -16.8632
25 N1y N 21.0356 -14.8409
26 C8x C 12.5977 -18.2579
27 C1y C 22.2210 -14.1436
28 C1x C 21.0356 -16.2356
29 C1x C 23.4063 -14.8409
30 C5a C 22.2210 -12.6791
31 C1x C 22.2210 -16.9329
32 N1y N 23.4065 -16.2356
33 N1b N 23.4763 -11.9818
34 O5a O 21.0356 -11.9818
35 C1b C 24.6617 -16.9329
36 C1d C 24.6617 -12.6791
37 C8y C 25.8472 -16.2356
38 C1a C 25.9170 -13.4462
39 C1a C 24.0341 -13.7252
40 C1a C 25.2894 -11.4937
41 C8x C 25.8472 -14.8409
42 C8x C 27.0327 -16.9329
43 C8x C 27.0327 -14.1436
44 N5x N 28.2879 -16.2356
45 C8x C 28.2879 -14.8409
46 S4a S 19.5014 -19.5131
47 O1d O 20.8961 -19.5131
48 O1d O 18.1067 -19.5131
49 O1d O 19.5014 -18.1184
50 O1d O 19.5014 -20.9078
BOND 53
1 1 2 1
2 1 3 2
3 1 4 1
4 2 5 1
5 2 6 1 #Up
6 3 7 1
7 3 8 1
8 4 9 2
9 5 10 1 #Up
10 6 11 1
11 8 12 2
12 11 13 1
13 11 14 2
14 13 15 1 #Up
15 13 16 1
16 15 17 1
17 16 18 1
18 17 19 2
19 17 20 1
20 18 21 1
21 18 22 1 #Up
22 19 23 1
23 20 24 2
24 21 25 1
25 23 26 2
26 25 27 1
27 25 28 1
28 27 29 1
29 27 30 1 #Down
30 28 31 1
31 29 32 1
32 30 33 1
33 30 34 2
34 32 35 1
35 33 36 1
36 35 37 1
37 36 38 1
38 36 39 1
39 36 40 1
40 37 41 1
41 37 42 2
42 41 43 2
43 42 44 1
44 43 45 1
45 5 7 1
46 9 12 1
47 24 26 1
48 31 32 1
49 44 45 2
50 46 47 1
51 46 48 1
52 46 49 2
53 46 50 2
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