KEGG   DRUG: Sotalol hydrochloride
Entry
D01026                      Drug                                   
Name
Sotalol hydrochloride (JAN/USP);
Betapace (TN);
Sorine (TN)
Product
  Generic
Formula
C12H20N2O3S. HCl
Exact mass
308.0961
Mol weight
308.8247
Structure
Simcomp
Class
Cardiovascular agent
 DG01466  Adrenergic receptor antagonist
  DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
 DG01653  Antiarrhythmics
  DG01648  Class III antiarrhythmic agent
Remark
Therapeutic category: 2129
ATC code: C07AA07
Chemical structure group: DG00307
Product (DG00307): D01026<JP/US>
Efficacy
Antiarrhythmic, beta-Adrenergic receptor antagonist, Potassium channel blocker
Target
ADRB1 [HSA:153] [KO:K04141]
ADRB2 [HSA:154] [KO:K04142]
KCNH2 [HSA:3757] [KO:K04905]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
Interaction
Structure map
map07037  Antiarrhythmic drugs
map07232  Potassium channel blocking and opening drugs
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA07 Sotalol
      D01026  Sotalol hydrochloride (JAN/USP) <JP/US>
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Antiarrhythmics
   Vaughn Williams-Class III
    Sotalol
     D01026  Sotalol hydrochloride (JAN/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   212  Antiarrhythmic agents
    2129  Others
     D01026  Sotalol hydrochloride (JAN/USP)
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00307  Sotalol
     D01026  Sotalol hydrochloride
  DG01653  Antiarrhythmics
   DG01648  Class III antiarrhythmic agent
    DG00307  Sotalol
     D01026  Sotalol hydrochloride
Drug classes [BR:br08332]
 Cardiovascular agent
  DG01653  Antiarrhythmics
   D01026  Sotalol hydrochloride
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    ADRB1
     D01026  Sotalol hydrochloride (JAN/USP) <JP/US>
    ADRB2
     D01026  Sotalol hydrochloride (JAN/USP) <JP/US>
 Ion channels
  Voltage-gated ion channels
   Potassium channels
    KCNH2
     D01026  Sotalol hydrochloride (JAN/USP) <JP/US>
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01466  Adrenergic receptor antagonist
   DG01464  beta-Adrenergic receptor antagonist (Beta blocker)
    DG00307  Sotalol
  DG01653  Antiarrhythmics
   DG01648  Class III antiarrhythmic agent
    DG00307  Sotalol
Other DBs
CAS: 959-24-0
PubChem: 7848089
ChEBI: 9207
LigandBox: D01026
NIKKAJI: J300.663H
LinkDB
KCF data

ATOM        19
            1   C8y C    20.3000  -16.1700
            2   C1c C    21.4900  -16.8700
            3   C8x C    20.3000  -14.7700
            4   C8x C    19.0400  -16.8700
            5   C1b C    22.6800  -16.1700
            6   O1a O    21.4900  -18.2700
            7   C8x C    19.0400  -14.0700
            8   C8x C    17.8500  -16.1700
            9   N1b N    23.9400  -16.8700
            10  C8y C    17.8500  -14.7700
            11  C1c C    25.1300  -16.1700
            12  N1b N    16.6600  -14.0700
            13  C1a C    26.3900  -16.8700
            14  C1a C    25.1300  -14.7700
            15  S4a S    15.4000  -14.7700
            16  C1a C    14.2100  -14.0700
            17  O3c O    16.6600  -15.4700
            18  O3c O    14.3500  -15.4700
            19  X   Cl   30.0300  -16.9400
BOND        18
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 1
            8     5   9 1
            9     7  10 1
            10    9  11 1
            11   10  12 1
            12   11  13 1
            13   11  14 1
            14   12  15 1
            15   15  16 1
            16   15  17 2
            17   15  18 2
            18    8  10 2

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