KEGG   DRUG: NateglinideHelp
Entry
D01111                      Drug                                   

Name
Nateglinide (JP17/USAN/INN);
Starsis (TN)
Product
  Generic
Formula
C19H27NO3
Exact mass
317.1991
Mol weight
317.4226
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
 DG01735  Glinide
 DG02044  Hypoglycemics
  DG01735  Glinide
Enzyme substrate
 DG01642  CYP2C9 substrate
 DG01633  CYP3A substrate
Remark
Same as: C12508
Therapeutic category: 3969
ATC code: A10BX03
Product: D01111<JP/US>
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Glinide derivative
Treatment of Type II diabetes mellitus
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
hsa02010  ABC transporters
hsa04911  Insulin secretion
hsa04930  Type II diabetes mellitus
Metabolism
Enzyme: CYP2C9 [HSA:1559]
Interaction
Drug interaction
Structure map
map07051  Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BX Other blood glucose lowering drugs, excl. insulins
     A10BX03 Nateglinide
      D01111  Nateglinide (JP17/USAN/INN) <JP/US>
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Nateglinide
    D01111  Nateglinide (JP17/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D01111  Nateglinide (JP17/USAN/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC subfamily
    ABCC8(SUR1)/KCNJ11(KIR6.2)
     D01111  Nateglinide (JP17/USAN/INN) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01111  Nateglinide
  D01111  Nateglinide tablets
Drug classes of therapeutic agents [br08360.html]
 Antidiabetic agents
  D01111
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D01111
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D01111
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D01111
BRITE hierarchy
Other DBs
CAS: 105816-04-4
PubChem: 7848174
ChEBI: 31897
ChEMBL: CHEMBL783
DrugBank: DB00731
LigandBox: D01111
NIKKAJI: J259.863I J263.263B
LinkDB All DBs
KCF data Show

ATOM        23
            1   C1b C    21.1279  -14.8259
            2   C1c C    21.1279  -16.2406
            3   C6a C    22.3304  -16.9480
            4   O6a O    22.3304  -18.3627
            5   O6a O    23.4622  -16.3114
            6   N1b N    19.8547  -16.9480
            7   C8y C    22.3304  -14.1186
            8   C8x C    22.3304  -12.7039
            9   C8x C    23.4622  -11.9965
            10  C8x C    24.7354  -12.7039
            11  C8x C    24.7354  -14.1186
            12  C8x C    23.5329  -14.8259
            13  C5a C    18.6522  -16.2406
            14  C1y C    17.3789  -16.8772
            15  O5a O    18.6522  -14.8259
            16  C1x C    17.3789  -18.2919
            17  C1x C    16.1764  -18.9993
            18  C1y C    14.9740  -18.2212
            19  C1x C    14.9740  -16.8772
            20  C1x C    16.1764  -16.1699
            21  C1c C    13.7715  -18.9286
            22  C1a C    12.5690  -18.2212
            23  C1a C    13.7715  -20.3433
BOND        24
            1     2   6 1
            2     2   1 1 #Down
            3     2   3 1
            4     3   4 2
            5     3   5 1
            6     1   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10  11 1
            11   11  12 2
            12    7  12 1
            13    6  13 1
            14   14  13 1 #Down
            15   13  15 2
            16   14  16 1
            17   16  17 1
            18   17  18 1
            19   18  19 1
            20   19  20 1
            21   14  20 1
            22   18  21 1 #Up
            23   21  22 1
            24   21  23 1

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