KEGG   DRUG: Profenamine hydrochlorideHelp
Entry
D01118                      Drug                                   

Name
Profenamine hydrochloride (JAN);
Ethopropazine hydrochloride;
Parkin (TN);
Parsidol (TN)
Formula
C19H24N2S. HCl
Exact mass
348.1427
Mol weight
348.9332
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
  DG01745  Anticholinergic antiparkinson agent
 DG01745  Anticholinergic antiparkinson agent
 DG01967  Antiparkinson agent
  DG01745  Anticholinergic antiparkinson agent
Remark
ATC code: N04AA05
Chemical structure group: DG00855
Efficacy
Antiparkinsonian, Muscarinic acetylcholine receptor antagonist
  Disease
Parkinsonism [DS:H01600]
Comment
Phenothiazine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04725  Cholinergic synapse
Interaction
Drug interaction
Structure map
map07029  Antipsychotics - phenothiazines
map07057  Antiparkinsonian agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N04 ANTI-PARKINSON DRUGS
   N04A ANTICHOLINERGIC AGENTS
    N04AA Tertiary amines
     N04AA05 Profenamine
      D01118  Profenamine hydrochloride (JAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    CHRM
     D01118  Profenamine hydrochloride (JAN)
BRITE hierarchy
Other DBs
CAS: 1094-08-2
PubChem: 7848181
ChEBI: 31568
ChEMBL: CHEMBL1200970
DrugBank: DB00392
LigandBox: D01118
NIKKAJI: J252.869J
LinkDB All DBs
KCF data Show

ATOM        23
            1   C8x C     7.2100   -9.8000
            2   C8x C     7.2100  -11.2000
            3   C8x C     8.4224  -11.9000
            4   C8y C     9.6349  -11.2000
            5   C8y C     9.6349   -9.8000
            6   C8x C     8.4224   -9.1000
            7   S2x S    10.8473  -11.9000
            8   C8y C    12.0597  -11.2000
            9   C8y C    12.0597   -9.8000
            10  N4y N    10.8473   -9.1000
            11  C8x C    13.2722  -11.9000
            12  C8x C    14.4846  -11.2000
            13  C8x C    14.4846   -9.8000
            14  C8x C    13.2722   -9.1000
            15  C1b C    10.8473   -7.7000
            16  C1c C    12.0618   -6.9988
            17  C1a C    13.2583   -7.6898
            18  N1c N    12.0618   -5.6002
            19  C1b C    13.2579   -4.9095
            20  C1b C    10.8330   -4.8906
            21  C1a C     9.6293   -5.5855
            22  C1a C    14.4453   -5.5951
            23  X   Cl   18.6900  -10.1500
BOND        24
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11    5  10 1
            12    8  11 1
            13   11  12 2
            14   12  13 1
            15   13  14 2
            16    9  14 1
            17   10  15 1
            18   15  16 1
            19   16  17 1
            20   16  18 1
            21   18  19 1
            22   18  20 1
            23   20  21 1
            24   19  22 1

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