KEGG ORTHOLOGY: K04133

ORTHOLOGY: K04133

Entry

K04133                      KO

Symbol

CHRM5

Name

muscarinic acetylcholine receptor M5

Pathway

map04020

Calcium signaling pathway

map04080

Neuroactive ligand-receptor interaction

map04725

Cholinergic synapse

map04810

Regulation of actin cytoskeleton

map05010

Alzheimer disease

map05022

Pathways of neurodegeneration - multiple diseases

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04020 Calcium signaling pathway
    K04133  CHRM5; muscarinic acetylcholine receptor M5
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    K04133  CHRM5; muscarinic acetylcholine receptor M5
09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K04133  CHRM5; muscarinic acetylcholine receptor M5
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    K04133  CHRM5; muscarinic acetylcholine receptor M5
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04133  CHRM5; muscarinic acetylcholine receptor M5
   05022 Pathways of neurodegeneration - multiple diseases
    K04133  CHRM5; muscarinic acetylcholine receptor M5
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors
    K04133  CHRM5; muscarinic acetylcholine receptor M5
G protein-coupled receptors [BR:ko04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    K04133  CHRM5; muscarinic acetylcholine receptor M5

Other DBs

GO:

0016907

Genes

HSA:	1133(CHRM5)

PTR:	503515(CHRM5)

PPS:	100969893(CHRM5)

GGO:	101139774(CHRM5)

PON:	100434598(CHRM5)

PPYG:

129013794(CHRM5)

NLE:	100600187(CHRM5)

HMH:	116482614(CHRM5)

SSYN:

129482574(CHRM5)

MCC:	574330(CHRM5)

MCF:	102127158(CHRM5)

MTHB:

126958839

MNI:	105463652(CHRM5)

CSAB:

103245911(CHRM5)

CATY:

105600623(CHRM5)

PANU:

101014406(CHRM5)

TGE:	112627662(CHRM5)

MLEU:

105546019(CHRM5)

RRO:	104680382(CHRM5)

RBB:	108518797(CHRM5)

TFN:	117070926(CHRM5)

PTEH:

111554580(CHRM5)

CANG:

105505014(CHRM5)

CJC:	100404308(CHRM5)

SBQ:	101042089(CHRM5)

CIMI:

108311906(CHRM5)

ANAN:

105726128(CHRM5)

CSYR:

103255547(CHRM5)

MMUR:

105859219(CHRM5)

LCAT:

123621759(CHRM5)

PCOQ:

105814510(CHRM5)

OGA:	100941460(CHRM5)

MMU:	213788(Chrm5)

MCAL:

110289866(Chrm5)

MPAH:

110318980(Chrm5)

RNO:	53949(Chrm5)

MCOC:

116090648(Chrm5)

ANU:	117704121(Chrm5)

MUN:	110555487(Chrm5)

CGE:	100773423(Chrm5)

MAUA:

101827372(Chrm5)

PROB:

127221769(Chrm5)

PLEU:

114683079(Chrm5) 114697493

MORG:

121465668(Chrm5)

MFOT:

126496811

AAMP:

119815576(Chrm5)

NGI:	103740509(Chrm5)

HGL:	101719201(Chrm5)

CPOC:

100379240(Chrm5)

CCAN:

109689428(Chrm5)

DORD:

105984254(Chrm5)

DSP:	122114594(Chrm5)

PLOP:

125340754(Chrm5)

NCAR:

124970388

MMMA:

107137816(Chrm5)

OCU:

100342984

OPI:	101526778(CHRM5)

TUP:	102494421(CHRM5)

GVR:	103584462 103597458

CFA:	487472(CHRM5)

CLUD:

112676193(CHRM5)

VVP:	112919913(CHRM5)

VLG:	121478258(CHRM5)

NPO:	129504266(CHRM5)

AML:	100480193(CHRM5)

UMR:	103673502(CHRM5)

UAH:	113241933(CHRM5)

UAR:	123776435(CHRM5)

ELK:

111140224

LLV:

125105102

MPUF:

101679448(CHRM5)

MNP:	131998679(CHRM5)

MLK:	131836062(CHRM5)

NVS:	122893445(CHRM5)

ORO:	101363589(CHRM5)

EJU:	114221456(CHRM5)

ZCA:	113908738(CHRM5)

MLX:	118003738(CHRM5)

NSU:	110585378(CHRM5)

LWW:	102747257(CHRM5)

FCA:	101097246(CHRM5)

PYU:	121041442(CHRM5)

PCOO:

112856055(CHRM5)

PBG:	122468832(CHRM5)

PVIV:

125168601(CHRM5)

LRUF:

124508738

PTG:	102965519(CHRM5)

PPAD:

109258479(CHRM5)

PUC:

125909806

AJU:

106969890

HHV:	120221102(CHRM5)

BTA:	281686(CHRM5)

BOM:	102269437(CHRM5)

BIU:	109564896(CHRM5)

BBUB:

102392076(CHRM5)

BBIS:

104991621(CHRM5)

CHX:	102168455(CHRM5)

OAS:	101110766(CHRM5)

BTAX:

128054467(CHRM5)

ODA:	120853254(CHRM5)

CCAD:

122443335(CHRM5)

MBEZ:

129562455 129563413

SSC:	100155818(CHRM5)

CFR:	102521882(CHRM5)

CBAI:

105076863(CHRM5)

CDK:	105089979(CHRM5)

VPC:	102533892(CHRM5)

BACU:

103004229(CHRM5)

BMUS:

118889505 118890722(CHRM5) 118890809

LVE:	103077653(CHRM5)

OOR:	101290143(CHRM5)

DLE:	111181590(CHRM5)

PCAD:

102975642(CHRM5)

PSIU:

116749393(CHRM5)

NASI:

112406800(CHRM5)

ECB:	100057856(CHRM5)

EPZ:	103548530(CHRM5)

EAI:	106835210(CHRM5)

MYB:	102238762(CHRM5)

MYD:	102765864(CHRM5)

MMYO:

118649380(CHRM5)

MLF:	102432519(CHRM5)

MDT:	132239384(CHRM5)

PKL:	118724064(CHRM5)

EFUS:

103287276(CHRM5)

MNA:	107526945(CHRM5)

DRO:	112311842(CHRM5)

SHON:

118993543(CHRM5)

AJM:	119040261(CHRM5)

PDIC:

114490307(CHRM5)

PHAS:

123808688(CHRM5)

MMF:	118641158(CHRM5)

PPAM:

129064077(CHRM5)

HAI:	109373436(CHRM5)

RFQ:	117023258(CHRM5)

PALE:

102882247(CHRM5)

PGIG:

120587228(CHRM5)

PVP:	105288600(CHRM5)

RAY:	107518787(CHRM5)

MJV:	108397399(CHRM5)

TOD:	119237893(CHRM5)

SARA:

101543901(CHRM5)

SETR:

126032087(CHRM5)

LAV:	100656243(CHRM5)

TMU:

101361367

ETF:	101649961(CHRM5)

DNM:	101437672(CHRM5)

MDO:	100026723(CHRM5)

GAS:	123235987(CHRM5)

SHR:	100916942(CHRM5)

AFZ:

127549186

PCW:	110215180(CHRM5)

TVP:	118829971(CHRM5)

GGA:	428881(CHRM5)

PCOC:

116229311(CHRM5)

MGP:	100542687(CHRM5)

CJO:	107314936(CHRM5)

TPAI:

128086614(CHRM5)

LMUT:

125695289(CHRM5)

NMEL:

110401754(CHRM5)

APLA:

101805433(CHRM5)

ACYG:

106031699(CHRM5)

CATA:

118244610(CHRM5)

AFUL:

116489998(CHRM5)

TGU:	100228639(CHRM5)

LSR:	110475270(CHRM5)

SCAN:

103826586(CHRM5)

PMOA:

120500317(CHRM5)

OTC:	121333104(CHRM5)

PRUF:

121349509(CHRM5)

GFR:	102040192(CHRM5)

FAB:	101819745(CHRM5)

OMA:	130253820(CHRM5)

PHI:	102103122(CHRM5)

PMAJ:

107205564(CHRM5)

CCAE:

111930319 111930320

CCW:	104684077(CHRM5)

CBRC:

103620819(CHRM5)

ETL:	114055326(CHRM5)

ZAB:	102071040(CHRM5)

ZLE:	135448043(CHRM5)

ACHL:

103801448(CHRM5)

SVG:	106848963(CHRM5)

MMEA:

130578761(CHRM5)

HRT:	120754306(CHRM5)

SATI:

136363193(CHRM5)

FPG:	101923678(CHRM5)

FCH:	102045801(CHRM5)

CCRI:

104156936(CHRM5)

NNT:	104401222(CHRM5)

SHAB:

115606166(CHRM5)

ACUN:

113480276(CHRM5)

TALA:

104365687(CHRM5)

ACHC:

115334503(CHRM5)

HALD:

104317448(CHRM5)

HLE:	104835938(CHRM5)

AGEN:

126049209

GCL:

127017170

CSTI:

104557079(CHRM5)

LDI:	104345007(CHRM5)

MNB:	103776822(CHRM5)

DPUB:

104306839(CHRM5)

AVIT:

104274767(CHRM5)

BRHI:

104497246(CHRM5)

EGZ:	104122089(CHRM5)

NNI:	104020290(CHRM5)

PCRI:

104038579(CHRM5)

PCAO:

104044094(CHRM5)

PADL:

103914355(CHRM5)

AFOR:

103902593(CHRM5)

FGA:	104072130(CHRM5)

GSTE:

104262885(CHRM5)

CLV:	102091916(CHRM5)

MUI:	104542164(CHRM5)

PGUU:

104462060(CHRM5)

PLET:

104622268(CHRM5)

EHS:	104505351(CHRM5)

CMAC:

104485793(CHRM5)

CUCA:

104059031(CHRM5)

TEO:	104376166(CHRM5)

BREG:

104634246(CHRM5)

OHA:	104326956(CHRM5)

ACAR:

104523304(CHRM5)

CPEA:

104397691(CHRM5)

CVF:	104286903(CHRM5)

RTD:	128909003(CHRM5)

AAM:	106483109(CHRM5)

AROW:

112971041(CHRM5)

NPD:	112957997(CHRM5)

TGT:	104567918(CHRM5)

DNE:	112980613(CHRM5)

SCAM:

104140223(CHRM5)

ASN:	102373374(CHRM5)

AMJ:	102566039(CHRM5)

CPOO:

109320980(CHRM5)

GGN:	109299478(CHRM5)

PSS:	102453097(CHRM5)

CMY:	102942482(CHRM5)

CCAY:

125638621(CHRM5)

DCC:	119856985(CHRM5)

CPIC:

101938589(CHRM5)

TST:	117876693(CHRM5)

CABI:

116826163(CHRM5)

MRV:	120404712(CHRM5)

ACS:	100562127(chrm5)

ASAO:

132765812(CHRM5)

PVT:	110080110(CHRM5)

SUND:

121935998(CHRM5)

PBI:	103066985(CHRM5)

PMUR:

107296429(CHRM5)

CTIG:

120307183(CHRM5)

TSR:	106544433(CHRM5)

PGUT:

117665705(CHRM5)

APRI:

131187663(CHRM5)

PTEX:

113439232(CHRM5)

NSS:	113409951(CHRM5)

VKO:	123026700(CHRM5)

PMUA:

114593576(CHRM5)

PRAF:

128410565(CHRM5)

ZVI:	118082895(CHRM5)

HCG:	128338268(CHRM5)

GJA:	107116075(CHRM5)

STOW:

125426119(CHRM5)

EMC:	129324554(CHRM5)

XLA:	108699222(chrm5.L) 108699716(chrm5.S)

XTR:	100498518(chrm5)

NPR:	108785168(CHRM5)

RTEM:

120921174(CHRM5)

BBUF:

120982121(CHRM5)

BGAR:

122922186(CHRM5)

DRE:	553978(chrm5a) 561491(chrm5b)

SRX:	107721291 107740779 107743900 107756593

SANH:

107668210 107668256 107671776 107678749 107687221

SGH:	107549091 107598160 107601926

CCAR:

109078610 109092548 109098539

CAUA:

113037829 113063121 113071635 113117806

CGIB:

127933185 127938816 127972847 127976785 127984394

PTET:

122325081(chrm5b) 122334448(chrm5a)

LROH:

127180109(chrm5a) 127183503(chrm5b)

OMC:	131523267(chrm5a) 131527781(chrm5b)

PPRM:

120477877 120477946 120493546(chrm5b)

RKG:	130071837(chrm5a) 130075506(chrm5b)

MAMB:

125269222(chrm5a) 125277818(chrm5b)

CIDE:

127498922 127499062 127501877

CERY:

137006311(chrm5a) 137018419(chrm5b)

MASI:

127410069 127410709 127416216 127455185

TROS:

130560467(chrm5a) 130566204(chrm5b)

TDW:	130434369(chrm5b) 130436989(chrm5a)

MANU:

129417760(chrm5a) 129430100(chrm5b)

IPU:	108257652(chrm5b) 108269673(chrm5a)

IFU:	128601197(chrm5b) 128613208(chrm5a)

PHYP:

113530104 113531940(chrm5)

SMEO:

124377183(chrm5b)

TFD:	113655591(chrm5b) 113660311(chrm5a)

TVC:	132842317(chrm5b) 132852805

TRN:	134320891(chrm5b) 134325411(chrm5a)

AMEX:

103025843(chrm5a) 103046753(chrm5b)

CMAO:

118815644(chrm5b) 118823305(chrm5a)

EEE:	113570523(chrm5) 113571331

CHAR:

105899398(chrm5b) 105908267(chrm5a)

TRU:	101061587 101062455

TFS:	130516555 130540151(chrm5a)

TNG:	GSTEN00022981G001 GSTEN00032378G001

LCO:	104926704 104937377(chrm5)

NCC:	104954959 104960050(chrm5)

TBEN:

117479096(chrm5a) 117486923

CGOB:

115004006(chrm5) 115027436

PGEO:

117439828 117467316(chrm5a)

GACU:

117549259 117549960

EMAC:

134876640 134881347

ELY:	117266904(chrm5a) 117270696

EFO:	125896720 125900420(chrm5a)

PLEP:

121954004(chrm5a) 121955214

SLUC:

116035829(chrm5a) 116066264(chrm5b)

ECRA:

117935929(chrm5a) 117961614(chrm5b)

ESP:	116669997(chrm5) 116706059

PFLV:

114547334 114573643

GAT:	120808426 120832543(chrm5a)

PPUG:

119195141(chrm5b) 119227453(chrm5a)

AFB:	129103867(chrm5a) 129106991

CLUM:

117725174(chrm5a) 117727897

PSWI:

130201418(chrm5a) 130202766(chrm5b)

MSAM:

119908507 119910883(chrm5a)

SCHU:

122861969(chrm5a) 122863129(chrm5b)

CUD:	121521238 121526634(chrm5a)

ALAT:

119004379(chrm5a) 119013080(chrm5b)

MZE:	101485814(chrm5) 112434385

ONL:	100534442(chrm5a) 100534444(chrm5)

OAU:	116322385(chrm5a) 116325275

OLA:	101158907 101169892

OML:	112148849(chrm5a) 112158267(chrm5b)

CSAI:

133462110(chrm5a) 133464621(chrm5b)

XMA:	102217332 102222626

XCO:	114134250 114158773

XHE:	116709074 116733681

PRET:

103457341 103458524(chrm5)

PFOR:

103129559 103136125

PLAI:

106940597 106960735(chrm5)

PMEI:

106930617 106930734(chrm5)

GAF:	122824886(chrm5b) 122846569(chrm5a)

PPRL:

129365199(chrm5a) 129375396(chrm5b)

CVG:	107084044 107093663

CTUL:

119785642(chrm5b) 119787567(chrm5a)

GMU:	124855960(chrm5a) 124881806(chrm5b)

NFU:	107377814(chrm5) 107392444

KMR:	108232519(chrm5a) 108233425(chrm5b)

ALIM:

106520150 106522438(chrm5)

NWH:	119418604(chrm5b) 119427568(chrm5a)

AOCE:

111569567 111587665

MCEP:

124999513(chrm5b) 125023936(chrm5a)

CSEM:

103381170(chrm5) 103392924

POV:	109627979 109636055(chrm5)

SSEN:

122782771(chrm5a) 122784058(chrm5b)

HHIP:

117755506(chrm5a) 117758601(chrm5b)

HSP:	118099705 118116557(chrm5a)

PPLT:

128451167(chrm5a) 128460118

SMAU:

118286646(chrm5a) 118289764(chrm5b)

LCF:	108887251(chrm5b) 108892616

SDU:	111216361(chrm5) 111225830

SLAL:

111661522(chrm5) 111663115

XGL:	120788981(chrm5b) 120795613(chrm5a)

HCQ:	109515984 109523740(chrm5)

SSCV:

125980432 125989741

SBIA:

133496894(chrm5b) 133513332(chrm5a)

PEE:	133412756(chrm5a) 133417412(chrm5b)

PTAO:

133467925(chrm5b) 133488184(chrm5a)

BPEC:

110155663 110170352

MALB:

109962302(chrm5) 109967981

BSPL:

114848131(chrm5a) 114849504(chrm5b)

SJO:	128375441 128376865

SASA:

106571100 106587421 106608254 106610907

STRU:

115156779 115162729 115172648 115174380

OTW:	112217954 112251684 112256661 112261818

OMY:	110497952 110505505 110522580 110529310

OGO:	123991679 123995405(chrm5b) 124001100 124045253

ONE:	115125621 115138472 115140441 115146250

OKI:	109866212 109882282 109894522 109904021

OKE:	118362455 118368341 118374788 118387134

SALP:

111954565 111968764 111973406 112080553

SNH:	120023724 120024606 120039758 120060231

CCLU:

121539251 121544939 121549358 121552774

ELS:	105015670 105024354

SFM:	108919496(chrm5)

PKI:	111838822(chrm5)

AANG:

118224312(chrm5a) 118229821

LOC:	102689322(chrm5)

PSPA:

121324954 121329963

ARUT:

117419395(chrm5a)

PSEX:

120518456

LCM:	102363863(CHRM5)

CMK:	103175376(chrm5b)

RTP:

109914693

CPLA:

122553726(chrm5b)

HOC:	132818178(chrm5b)

LERI:

129700334(chrm5b)

PMRN:

BBEL:

LPIC:

ARUN:

SKO:

DSV:

RSAN:

RMP:

VDE:

VJA:

UDV:

SDM:

BGT:	106065626 106070826

GAE:

CANU:

DPOL:

NVE:

ATEN:

RES:

Reference

PMID:3272174

Authors

Bonner TI, Young AC, Brann MR, Buckley NJ

Title

Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.

Journal

Neuron 1:403-10 (1988)
DOI:10.1016/0896-6273(88)90190-0

Sequence

[hsa:1133]

LinkDB

DBGET integrated database retrieval system