KEGG T01001: 1133

Homo sapiens (human): 1133

Entry

1133              CDS       T01001

Symbol

CHRM5, HM5

Name

(RefSeq) cholinergic receptor muscarinic 5

K04133

muscarinic acetylcholine receptor M5

Organism

hsa Homo sapiens (human)

Pathway

hsa04020

Calcium signaling pathway

hsa04080

Neuroactive ligand-receptor interaction

hsa04082

Neuroactive ligand signaling

hsa04725

Cholinergic synapse

hsa04810

Regulation of actin cytoskeleton

hsa05010

Alzheimer disease

hsa05022

Pathways of neurodegeneration - multiple diseases

Network

nt06460  Alzheimer disease
nt06466  Pathways of neurodegeneration
nt06528  Calcium signaling
nt06544  Neuroactive ligand signaling

Element

N01000

mAChR-Ca2+ -apoptotic pathway

N01001

Mutation-caused aberrant Abeta to mAchR-Ca2+ -apoptotic pathway

N01894

Acetylcholine-CHRM-GNAQ/11 signaling pathway

Drug target

Acetylcholine (DG01133):

D00999<JP/US>

Aclatonium (DG01291):

D01955

Aclidinium bromide:

D08837<JP/US>

Anisotropine methylbromide:

D00232

Atropine (DG00052):

D00113<US> D02069<JP/US>

Atropine oxide (DG01243):

D03011 D07477

Batefenterol (DG01627):

D10545 D10546

Benapryzine hydrochloride:

D03076

Benzatropine (DG00859):

D00778<US> D07511

Benzetimide (DG01301):

D03087 D07513

Benzilone:

D03088

Bethanechol (DG00991):

D01000<JP/US>

Bevonium:

D01532

Biperiden (DG00852):

D00779 D02246<JP> D02247<JP>

Blarcamesine (DG03048):

D11383 D11549

Bornaprine:

D07302

Butropium bromide:

D01491

Butylscopolamine:

D01451<JP>

Carbachol:

D00524<US>

Carpronium (DG01289):

D01175<JP> D09752<JP>

Chlorpromazine (DG00867):

D00270 D00789<JP/US> D03274 D04034<JP> D09819

Choline alfoscerate:

D07349

Cimetropium bromide:

D07099

Clidinium bromide:

D00716

Cyclopentolate (DG01141):

D01002<JP/US> D07759

Darotropium bromide:

D09402

Dexetimide (DG00856):

D03711 D07804

Diethazine (DG01921):

D02603 D07823

Difemerine:

D07079

Dihexyverine (DG00033):

D03824 D07821

Diphenidol (DG02880):

D01318<JP> D03858 D03859

Diphenylpiperidinomethyldioxolan iodide:

Diponium bromide:

Elantrine:

Elucaine:

Etomidoline:

Etybenzatropine:

Eucatropine hydrochloride:

Fenpiverinium:

Fentonium:

Flutropium bromide:

Glycopyrronium (DG02467):

D10939<JP/US>

Heteronium bromide:

D04434

Homatropine (DG01142):

D01004

Homatropine methylbromide:

D02070

Hyoscyamine (DG00053):

D00147 D00719 D01648 D04479

Ipratropium bromide:

D02212<JP/US>

Mazaticol (DG00857):

D03264 D08157

Mebeverine (DG00030):

D04868 D08160

Mepenzolate (DG00040):

D00720<JP>

Methacholine:

D04970<JP/US>

Methantheline (DG00036):

D00721

Methscopolamine bromide:

D00715<US>

Methylatropine (DG01242):

D01077 D03814

Methylbenactyzium bromide:

D01315

Methylscopolamine:

D01976<JP>

Metixene (DG00853):

D01871 D08209

Metoquizine:

D05012

Milameline hydrochloride:

Otilonium bromide:

Oxapium iodide:

Oxitropium bromide:

Oxybutynin (DG00478):

D00465<US> D00722<JP/US>

Parapenzolate bromide:

D05360

Pentapiperium methylsulfate:

Penthienate:

Phencarbamide:

Phenglutarimide:

Pipenzolate:

Piperidolate (DG00034):

D01165<JP> D08382

Pipethanate (DG01255):

D01521 D08384

Pipethanate ethobromide:

D01987

Pirenzepine (DG00026):

D01297 D05276<JP> D08389

Piroheptine (DG01272):

D01231<JP> D08395

Poldine:

D05535

Pridinol (DG00774):

D02064<JP> D08418 D08419

Prifinium bromide:

D01377

Procyclidine (DG00854):

D00782 D08425

Profenamine (DG00855):

D01118 D03276 D08426

Propantheline (DG00035):

D00481<JP>

Propenzolate hydrochloride:

D05628

Propiverine (DG00479):

D01007<JP> D08441

Rapacuronium bromide:

D05703

Rocuronium bromide:

D00765<JP/US>

Scopolamine (DG00065):

D00138<US> D02071

Tazomeline citrate:

D06015

Tematropium methylsulfate:

D06061

Tiemonium (DG01254):

D08595

Tiemonium iodide:

D01201

Timepidium bromide (DG00041):

D02535<JP>

Tofenacin hydrochloride:

D06175

Toquizine:

D06192

Triampyzine sulfate:

D06217

Trihexyphenidyl (DG00851):

D00787<JP/US> D08638

Tropatepine (DG00858):

D07303 D08653

Tropicamide:

D00397<JP/US>

Umeclidinium (DG01253):

D10180

Umeclidinium bromide:

D10181<JP/US>

Valethamate:

D01538

Brite

KEGG Orthology (KO) [BR:hsa00001]
09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04080 Neuroactive ligand-receptor interaction
    1133 (CHRM5)
   04082 Neuroactive ligand signaling
    1133 (CHRM5)
09150 Organismal Systems
  09156 Nervous system
   04725 Cholinergic synapse
    1133 (CHRM5)
09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    1133 (CHRM5)
   05022 Pathways of neurodegeneration - multiple diseases
    1133 (CHRM5)
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04030 G protein-coupled receptors [BR:hsa04030]
    1133 (CHRM5)
G protein-coupled receptors [BR:hsa04030]
Rhodopsin family
  Biogenic amine
   Acetylcholine (muscarinic)
    1133 (CHRM5)

SSDB

Motif

Pfam:

7tm_1 7TM_GPCR_Srsx 7TM_GPCR_Srx 7TM_GPCR_Srbc 7tm_4

Other DBs

NCBI-GeneID:

NCBI-ProteinID:

OMIM:

HGNC:

Ensembl:

UniProt:

Structure

LinkDB

Position

15:33968497..34067458

AA seq 532 aa
MEGDSYHNATTVNGTPVNHQPLERHRLWEVITIAAVTAVVSLITIVGNVLVMISFKVNSQ
LKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWALGSLACDLWLALDYVASNASVMN
LLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLISFILWAPAILCWQYLVGKRTVPL
DECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVTKAE
KRKPAHRALFRSCLRCPRPTLAQRERNQASWSSSRRSTSTTGKPSQATGPSANWAKAEQL
TTCSSYPSSEDEDKPATDPVLQVVYKSQGKESPGEEFSAEETEETFVKAETEKSDYDTPN
YLLSPAAAHRPKSQKCVAYKFRLVVKADGNQETNNGCHKVKIMPCPFPVAKEPSTKGLNP
NPSHQMTKRKRVVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLG
YWLCYVNSTVNPICYALCNRTFRKTFKMLLLCRWKKKKVEEKLYWQGNSKLP

NT seq 1599 nt +upstreamnt +downstreamnt
atggaaggggattcttaccacaatgcaaccaccgtcaatggcaccccagtaaatcaccag
cctttggaacgccacaggttgtgggaagtcatcaccattgcagctgtgactgctgtggta
agcctgatcaccattgtgggcaatgtcttggtcatgatctccttcaaagtcaacagccag
ctcaagacagttaacaactattacctgctcagcttagcctgtgcagatctcatcattgga
atcttctccatgaacctctacaccacctacatcctcatgggacgctgggctctcgggagt
ctggcttgtgacctttggcttgcactggactacgtggccagcaacgcttctgtcatgaac
cttctggtgatcagttttgaccgttacttttccatcacaagacccttgacatatcgggcc
aagcgtactccgaaaagggctggcatcatgattggcttggcctggctgatctccttcatc
ctctgggccccagcaatcctctgctggcagtacttggttgggaagcggacagttccactg
gatgagtgccagatccagtttctctctgagcccaccatcacttttggcactgccattgct
gccttctacatccctgtttctgtcatgaccatcctctactgtcgaatctaccgggaaaca
gagaagcgaaccaaggacctggctgacctccagggttctgactctgtgaccaaagctgag
aagagaaagccagctcatagggctctgttcagatcctgcttgcgctgtcctcgacccacc
ctggcccagcgggaaaggaaccaggcctcctggtcatcctcccgcaggagcacctccacc
actgggaagccatcccaagccactggcccaagcgccaattgggccaaagctgagcagctc
accacctgtagcagctacccttcctcagaggatgaggacaagcccgccactgaccctgtc
ctccaagtggtctacaagagtcagggtaaggaaagcccaggggaagaattcagtgctgaa
gagactgaggaaacttttgtgaaagctgaaactgaaaaaagtgactatgacaccccaaac
taccttctgtctccagcagctgctcatagacccaagagtcagaaatgtgtggcctataag
ttccgattggtggtaaaagctgacgggaaccaggagaccaacaatggctgtcacaaggtg
aaaatcatgccctgccccttcccagtggccaaggaaccttcaacgaaaggcctcaatccc
aaccccagccatcaaatgaccaaacgaaagagagtggtcctagtcaaagagaggaaagca
gcccagacactgagtgccattctcctggccttcatcatcacatggaccccgtataacatc
atggtcctggtttctaccttctgtgacaagtgtgtcccagtcaccctgtggcacttgggc
tattggttgtgctatgtcaatagcactgtcaaccccatctgctatgccctctgcaacaga
accttcaggaagacctttaagatgctgcttctctgccgatggaaaaagaaaaaagtggaa
gagaagttgtactggcaggggaacagcaagctaccctga

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