| Entry |
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| Name |
Ibuprofen piconol (JP18/USAN);
Staderm (TN) |
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| Formula |
C19H23NO2
|
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| Exact mass |
297.1729
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| Mol weight |
297.3914
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| Structure |
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| Class |
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
Dermatological agent
DG03243 Atopic dermatitis agent
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
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| Remark |
| Therapeutic category: | 2649 |
| Product (DG00245): | D00126<JP/US> D01122<JP> D06606<JP/US> |
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| Efficacy |
Analgesic, Anti-inflammatory, COX inhibitor |
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| Comment |
Propionic acid derivative
Active form of prodrug: Ibuprofen [DR: D00126]
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| Target |
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| Pathway |
|
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| Metabolism |
Enzyme: CYP2C9 [HSA: 1559]
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| Interaction |
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| Structure map |
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C01 CARDIAC THERAPY
C01E OTHER CARDIAC PREPARATIONS
C01EB Other cardiac preparations
C01EB16 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
G GENITO URINARY SYSTEM AND SEX HORMONES
G02 OTHER GYNECOLOGICALS
G02C OTHER GYNECOLOGICALS
G02CC Antiinflammatory products for vaginal administration
G02CC01 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
M MUSCULO-SKELETAL SYSTEM
M01 ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS
M01A ANTIINFLAMMATORY AND ANTIRHEUMATIC PRODUCTS, NON-STEROIDS
M01AE Propionic acid derivatives
M01AE01 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
M02 TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02A TOPICAL PRODUCTS FOR JOINT AND MUSCULAR PAIN
M02AA Antiinflammatory preparations, non-steroids for topical use
M02AA13 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
R RESPIRATORY SYSTEM
R02 THROAT PREPARATIONS
R02A THROAT PREPARATIONS
R02AX Other throat preparations
R02AX02 Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN) <JP>
USP drug classification [BR:br08302]
Analgesics
Nonsteroidal Anti-inflammatory Drugs
Ibuprofen
D01122 Ibuprofen piconol (JP18/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
26 Epidermides
264 Analgesics, anti-itchings, astringents, anti-inflammatory agents
2649 Others
D01122 Ibuprofen piconol (JP18/USAN)
Classification of Japanese OTC drugs [BR:br08313]
Agents for integumentary system
56 Purulent skin remedies
D01122 Ibuprofen piconol (JP18/USAN)
Risk category of Japanese OTC drugs [BR:br08312]
Second-class OTC drugs
Inorganic and organic chemicals
Ibuprofen piconol
D01122 Ibuprofen piconol (JP18/USAN)
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00245 Ibuprofen
D01122 Ibuprofen piconol
Dermatological agent
DG03243 Atopic dermatitis agent
D01122 Ibuprofen piconol
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
D01122 Ibuprofen piconol
Drug classes [BR:br08332]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
D01122 Ibuprofen piconol
Dermatological agent
DG03243 Atopic dermatitis agent
D01122 Ibuprofen piconol
Target-based classification of drugs [BR:br08310]
Enzymes
Oxidoreductases (EC1)
Prostaglandin synthase
PTGS1 (COX1)
D01122 Ibuprofen piconol (JP18/USAN) <JP>
PTGS2 (COX2)
D01122 Ibuprofen piconol (JP18/USAN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01122 Ibuprofen piconol ointment
D01122 Ibuprofen piconol cream
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01122
Prodrugs [br08324.html]
D01122
Rx-to-OTC switch list in Japan [br08314.html]
D01122
Drug groups [BR:br08330]
Anti-inflammatory
DG01504 Nonsteroidal anti-inflammatory drug (NSAID)
DG01908 Anti-inflammatory drug, propionic acid derivatives
DG00245 Ibuprofen
Metabolizing enzyme substrate
DG01642 CYP2C9 substrate
DG00245 Ibuprofen
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 22
1 C8x C 30.7421 -16.2559
2 C8y C 30.7421 -17.6563
3 N5x N 31.9578 -18.3565
4 C8x C 33.1663 -17.6563
5 C8x C 33.1663 -16.2559
6 C8x C 31.9578 -15.5557
7 C1b C 29.5296 -18.3570
8 O7a O 28.3166 -17.6575
9 C7a C 27.1042 -18.3583
10 C1c C 25.8910 -17.6587
11 O6a O 27.1048 -19.7587
12 C8y C 24.6787 -18.3595
13 C8x C 23.4712 -17.6571
14 C8x C 22.2589 -18.3580
15 C8y C 22.2595 -19.7584
16 C8x C 23.4727 -20.4579
17 C8x C 24.6850 -19.7570
18 C1b C 21.0471 -20.4591
19 C1c C 19.8339 -19.7596
20 C1a C 18.6216 -20.4604
21 C1a C 19.8332 -18.3592
22 C1a C 25.8903 -16.2583
BOND 23
1 9 11 2
2 5 6 2
3 10 12 1
4 6 1 1
5 2 7 1
6 1 2 2
7 7 8 1
8 12 13 2
9 13 14 1
10 14 15 2
11 15 16 1
12 16 17 2
13 17 12 1
14 2 3 1
15 15 18 1
16 8 9 1
17 18 19 1
18 3 4 2
19 19 20 1
20 9 10 1
21 19 21 1
22 4 5 1
23 10 22 1
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