| Entry |
|
|---|
| Name |
Tazarotene (JAN/USAN/INN);
Avage (TN);
Fabior (TN);
Tazorac (TN) |
|---|
| Product |
|
|---|
| Generic |
TAZAROTENE (Bryant Ranch Prepack), TAZAROTENE (Bryant Ranch Prepack), TAZAROTENE (Cosette Pharmaceuticals), TAZAROTENE (Cosette Pharmaceuticals), TAZAROTENE (Cosette Pharmaceuticals), TAZAROTENE (Mayne Pharma), TAZAROTENE (Mayne Pharma), TAZAROTENE (Pacific Pharma), TAZAROTENE (Padagis Israel Pharmaceuticals), TAZAROTENE (Padagis Israel Pharmaceuticals), TAZAROTENE (Solaris Pharma Corporation), TAZAROTENE (Taro Pharmaceuticals U.S.A.), TAZAROTENE (Taro Pharmaceuticals U.S.A.) |
|---|
| Formula |
C21H21NO2S
|
|---|
| Exact mass |
351.1293
|
|---|
| Mol weight |
351.46
|
|---|
| Structure |
|
|---|
| Simcomp |
|
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| Class |
Vitamin and mineral
DG01604 Retinol derivative
|
|---|
| Remark |
| Product (mixture): | D11932<US> |
|
|---|
| Efficacy |
Anti-acne, Antipsoriatic, Keratolytic, Retinoic acid receptor (RAR) agonist |
|---|
| Disease |
|
|---|
| Comment |
Active form of prodrug: Tazarotenic acid [CPD: C21518]
Carotenoid derivative
|
|---|
| Target |
|
|---|
| Pathway |
|
|---|
| Structure map |
| map07223 | Retinoic acid receptor (RAR) and retinoid X receptor (RXR) agonists/antagonists |
|
|---|
| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
D DERMATOLOGICALS
D05 ANTIPSORIATICS
D05A ANTIPSORIATICS FOR TOPICAL USE
D05AX Other antipsoriatics for topical use
D05AX05 Tazarotene
D01132 Tazarotene (JAN/USAN/INN) <US>
USP drug classification [BR:br08302]
Dermatological Agents
Acne and Rosacea Agents
Retinoids
Tazarotene
D01132 Tazarotene (JAN/USAN/INN)
Drug groups [BR:br08330]
Vitamin and mineral
DG01604 Retinol derivative
D01132 Tazarotene
Target-based classification of drugs [BR:br08310]
Nuclear receptors
Thyroid hormone like receptors
Retinoic acid receptor (RAR)
NR1B (RAR)
D01132 Tazarotene (JAN/USAN/INN) <US>
Hepatocyte nuclear factor 4 like receptors
Retinoid X receptor (RXR)
NR2B2 (RXRB)
D01132 Tazarotene (JAN/USAN/INN) <US>
Prodrugs [br08324.html]
D01132
|
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| Other DBs |
|
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| LinkDB |
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| KCF data |
ATOM 25
1 C8y C 26.8694 -16.3717
2 C8x C 28.0726 -17.0781
3 C8x C 29.2881 -16.3833
4 C8y C 29.2941 -14.9831
5 C8x C 28.0845 -14.2777
6 N5x N 26.8689 -14.9727
7 C7a C 30.5096 -14.2881
8 O7a O 31.7192 -14.9934
9 O6a O 30.5157 -12.8879
10 C1b C 32.9349 -14.2984
11 C1a C 34.1445 -15.0038
12 C1x C 18.3938 -18.4674
13 C1x C 18.3938 -19.8676
14 S2x S 19.6093 -20.5677
15 C1z C 19.6093 -17.7673
16 C8y C 20.8177 -18.4674
17 C8y C 20.8116 -19.8676
18 C8x C 22.0212 -20.5728
19 C8x C 23.2369 -19.8780
20 C8y C 23.2428 -18.4778
21 C8x C 22.0332 -17.7724
22 C1a C 20.5930 -16.7702
23 C1a C 18.6059 -16.7702
24 C3b C 24.4584 -17.7830
25 C3b C 25.6634 -17.0742
BOND 27
1 2 3 1
2 3 4 2
3 4 5 1
4 5 6 2
5 6 1 1
6 4 7 1
7 7 8 1
8 7 9 2
9 8 10 1
10 10 11 1
11 13 14 1
12 14 17 1
13 16 15 1
14 15 12 1
15 16 17 2
16 17 18 1
17 18 19 2
18 19 20 1
19 20 21 2
20 21 16 1
21 15 22 1
22 12 13 1
23 15 23 1
24 20 24 1
25 1 2 2
26 24 25 3
27 25 1 1
|
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