Homo sapiens (human): 6257
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Entry
6257 CDS
T01001
Symbol
RXRB, DAUDI6, H-2RIIBP, NR2B2, RCoR-1, RXR-beta, RXRbeta
Name
(RefSeq) retinoid X receptor beta
KO
K08525
retinoid X receptor beta
Organism
hsa
Homo sapiens (human)
Pathway
hsa03320
PPAR signaling pathway
hsa04659
Th17 cell differentiation
hsa04919
Thyroid hormone signaling pathway
hsa04920
Adipocytokine signaling pathway
hsa04928
Parathyroid hormone synthesis, secretion and action
hsa05200
Pathways in cancer
hsa05202
Transcriptional misregulation in cancer
hsa05207
Chemical carcinogenesis - receptor activation
hsa05216
Thyroid cancer
hsa05222
Small cell lung cancer
hsa05223
Non-small cell lung cancer
hsa05226
Gastric cancer
hsa05417
Lipid and atherosclerosis
Network
nt06240
Transcription (cancer)
nt06274
Thyroid cancer
nt06322
TRH-TSH-TH signaling
Element
N00126
PAX8-PPARG fusion to PPARG-mediated transcription
N00798
Thyroid hormone signaling pathway
Drug target
Acitretin:
D02754
<US>
Adapalene:
D01112
<JP/US>
Alitretinoin:
D02815
<US>
Bexarotene:
D03106
<JP/US>
Etretinate:
D00316
<JP>
Tazarotene:
D01132
<US>
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09150 Organismal Systems
09151 Immune system
04659 Th17 cell differentiation
6257 (RXRB)
09152 Endocrine system
04920 Adipocytokine signaling pathway
6257 (RXRB)
03320 PPAR signaling pathway
6257 (RXRB)
04919 Thyroid hormone signaling pathway
6257 (RXRB)
04928 Parathyroid hormone synthesis, secretion and action
6257 (RXRB)
09160 Human Diseases
09161 Cancer: overview
05200 Pathways in cancer
6257 (RXRB)
05202 Transcriptional misregulation in cancer
6257 (RXRB)
05207 Chemical carcinogenesis - receptor activation
6257 (RXRB)
09162 Cancer: specific types
05226 Gastric cancer
6257 (RXRB)
05216 Thyroid cancer
6257 (RXRB)
05222 Small cell lung cancer
6257 (RXRB)
05223 Non-small cell lung cancer
6257 (RXRB)
09166 Cardiovascular disease
05417 Lipid and atherosclerosis
6257 (RXRB)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors [BR:
hsa03000
]
6257 (RXRB)
09183 Protein families: signaling and cellular processes
03310 Nuclear receptors [BR:
hsa03310
]
6257 (RXRB)
Transcription factors [BR:
hsa03000
]
Eukaryotic type
Zinc finger
Cys4 hepatocyte nuclear factor 4-like
6257 (RXRB)
Nuclear receptors [BR:
hsa03310
]
2. Hepatocyte nuclear factor 4 like
2B. Retinoid X receptor (RXR)
6257 (RXRB)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
Hormone_recep
zf-C4
Nuc_recep-AF1
Motif
Other DBs
NCBI-GeneID:
6257
NCBI-ProteinID:
NP_068811
OMIM:
180246
HGNC:
10478
Ensembl:
ENSG00000204231
UniProt:
P28702
Q5STP9
Structure
PDB
PDBj
LinkDB
All DBs
Position
6:complement(33193588..33200853)
Genome browser
AA seq
533 aa
AA seq
DB search
MSWAARPPFLPQRHAAGQCGPVGVRKEMHCGVASRWRRRRPWLDPAAAAAAAVAGGEQQT
PEPEPGEAGRDGMGDSGRDSRSPDSSSPNPLPQGVPPPSPPGPPLPPSTAPSLGGSGAPP
PPPMPPPPLGSPFPVISSSMGSPGLPPPAPPGFSGPVSSPQINSTVSLPGGGSGPPEDVK
PPVLGVRGLHCPPPPGGPGAGKRLCAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLTYS
CRDNKDCTVDKRQRNRCQYCRYQKCLATGMKREAVQEERQRGKDKDGDGEGAGGAPEEMP
VDRILEAELAVEQKSDQGVEGPGGTGGSGSSPNDPVTNICQAADKQLFTLVEWAKRIPHF
SSLPLDDQVILLRAGWNELLIASFSHRSIDVRDGILLATGLHVHRNSAHSAGVGAIFDRV
LTELVSKMRDMRMDKTELGCLRAIILFNPDAKGLSNPSEVEVLREKVYASLETYCKQKYP
EQQGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQLA
NT seq
1602 nt
NT seq
+upstream
nt +downstream
nt
atgtcttgggccgctcgcccgcccttcctccctcagcggcatgccgcagggcagtgtggg
ccggtgggggtgcgaaaagaaatgcattgtggggtcgcgtcccggtggcggcggcgacgg
ccctggctggatcccgcagcggcggcggcggcggcggtggcaggcggagaacaacaaacc
ccggagccggagccaggggaggctggacgggacgggatgggcgacagcgggcgggactcc
cgaagcccagacagctcctccccaaatccccttccccagggagtccctcccccttctcct
cctgggccacccctacccccttcaacagctccatcccttggaggctctggggccccaccc
ccacccccgatgccaccacccccactgggctctccctttccagtcatcagttcttccatg
gggtcccctggtctgccccctccagctcccccaggattctccgggcctgtcagcagcccc
cagattaactcaacagtgtcactccctgggggtgggtctggcccccctgaagatgtgaag
ccaccagtcttaggggtccggggcctgcactgtccaccccctccaggtggccctggggct
ggcaaacggctatgtgcaatctgcggggacagaagctcaggcaaacactacggggtttac
agctgtgagggttgcaagggcttcttcaaacgcaccatccgcaaagaccttacatactct
tgccgggacaacaaagactgcacagtggacaagcgccagcggaaccgctgtcagtactgc
cgctatcagaagtgcctggccactggcatgaagagggaggcggtacaggaggagcgtcag
cggggaaaggacaaggatggggatggggagggggctgggggagcccccgaggagatgcct
gtggacaggatcctggaggcagagcttgctgtggaacagaagagtgaccagggcgttgag
ggtcctgggggaaccgggggtagcggcagcagcccaaatgaccctgtgactaacatctgt
caggcagctgacaaacagctattcacgcttgttgagtgggcgaagaggatcccacacttt
tcctccttgcctctggatgatcaggtcatattgctgcgggcaggctggaatgaactcctc
attgcctccttctcacaccgatccattgatgttcgagatggcatcctccttgccacaggt
cttcacgtgcaccgcaactcagcccattcagcaggagtaggagccatctttgatcgggtg
ctgacagagctagtgtccaaaatgcgtgacatgaggatggacaagacagagcttggctgc
ctgagggcaatcattctgtttaatccagatgccaagggcctctccaaccctagtgaggtg
gaggtcctgcgggagaaagtgtatgcatcactggagacctactgcaaacagaagtaccct
gagcagcagggacggtttgccaagctgctgctacgtcttcctgccctccggtccattggc
cttaagtgtctagagcatctgtttttcttcaagctcattggtgacacccccatcgacacc
ttcctcatggagatgcttgaggctccccatcaactggcctga
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