KEGG   DRUG: Clobetasol propionate
Entry
D01272                      Drug                                   
Name
Clobetasol propionate (JP18/USP);
Clobex (TN);
Cormax (TN);
Olux (TN)
Product
CLOBETASOL PROPIONATE (Eyenovia), CLOBEX (Galderma Laboratories), CLOBEX (Galderma Laboratories), CLOBEX (Galderma Laboratories), IMPOYZ (Primus Pharmaceuticals)
  Generic
CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (A-S Medication Solutions), CLOBETASOL PROPIONATE (Actavis Pharma), CLOBETASOL PROPIONATE (Actavis Pharma), CLOBETASOL PROPIONATE (Actavis Pharma), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Alembic Pharmaceuticals), CLOBETASOL PROPIONATE (Amneal Pharmaceuticals NY LLC), CLOBETASOL PROPIONATE (Amneal Pharmaceuticals NY LLC), CLOBETASOL PROPIONATE (Aurobindo Pharma Limited), CLOBETASOL PROPIONATE (AvKARE), CLOBETASOL PROPIONATE (AvKARE), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Bryant Ranch Prepack), CLOBETASOL PROPIONATE (Cosette Pharmaceuticals), CLOBETASOL PROPIONATE (DIRECT RX), CLOBETASOL PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLOBETASOL PROPIONATE (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLOBETASOL PROPIONATE (EMMOLIENT) (NuCare Pharmaceuticals), CLOBETASOL PROPIONATE (EMOLLIENT) (E. Fougera & Co. a division of Fougera Pharmaceuticals), CLOBETASOL PROPIONATE (Encube Ethicals Private Limited), CLOBETASOL PROPIONATE (Encube Ethicals Private Limited), CLOBETASOL PROPIONATE (Glenmark Pharmaceutcials), CLOBETASOL PROPIONATE (Glenmark Pharmaceuticals), CLOBETASOL PROPIONATE (Glenmark Pharmaceuticals), CLOBETASOL PROPIONATE (Glenmark Pharmaceuticals), CLOBETASOL PROPIONATE (Glenmark Pharmaceuticals), CLOBETASOL PROPIONATE (Glenmark Pharmaceuticals), CLOBETASOL PROPIONATE (Golden State Medical Supply), CLOBETASOL PROPIONATE (IPG PHARMACEUTICALS), CLOBETASOL PROPIONATE (Lupin Pharmaceuticals), CLOBETASOL PROPIONATE (Lupin Pharmaceuticals), CLOBETASOL PROPIONATE (Lupin Pharmaceuticals), CLOBETASOL PROPIONATE (Lupin Pharmaceuticals), CLOBETASOL PROPIONATE (Macleods Pharmaceuticals Limited), CLOBETASOL PROPIONATE (Macleods Pharmaceuticals Limited), CLOBETASOL PROPIONATE (Mayne Pharma), CLOBETASOL PROPIONATE (Micro Labs Limited), CLOBETASOL PROPIONATE (NORTHSTAR RX LLC), CLOBETASOL PROPIONATE (Northstar Rx LLC), CLOBETASOL PROPIONATE (Novel Laboratories), CLOBETASOL PROPIONATE (Novel Laboratories), CLOBETASOL PROPIONATE (NuCare Pharmaceuticals), CLOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), CLOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), CLOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), CLOBETASOL PROPIONATE (Padagis Israel Pharmaceuticals), CLOBETASOL PROPIONATE (Preferred Pharmaceuticals), CLOBETASOL PROPIONATE (Preferred Pharmaceuticals), CLOBETASOL PROPIONATE (Proficient Rx LP), CLOBETASOL PROPIONATE (Proficient Rx LP), CLOBETASOL PROPIONATE (Quagen Pharmaceuticals LLC), CLOBETASOL PROPIONATE (RPK Pharmaceuticals), CLOBETASOL PROPIONATE (Rising Pharmaceuticals), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Taro Pharmaceuticals U.S.A.), CLOBETASOL PROPIONATE (Torrent Pharmaceuticals Limited), CLOBETASOL PROPIONATE (Viona Pharmaceuticals), CLOBETASOL PROPIONATE (Xiromed), CLOBETASOL PROPIONATE (Xiromed), CLOBETASOL PROPIONATE (Zydus Lifesciences Limited), CLOBETASOL PROPIONATE (Zydus Lifesciences Limited), CLOBETASOL PROPIONATE (Zydus Lifesciences Limited), CLOBETASOL PROPIONATE (Zydus Lifesciences Limited), CLOBETASOL PROPIONATE (Zydus Pharmaceuticals USA), CLOBETASOL PROPIONATE (Zydus Pharmaceuticals USA), CLOBETASOL PROPIONATE (Zydus Pharmaceuticals USA), CLOBETASOL PROPIONATE CREAM USP, 0.05% (A-S Medication Solutions), CLOBETASOL PROPIONATE CREAM USP, 0.05% (Bryant Ranch Prepack), CLOBETASOL PROPIONATE CREAM USP, 0.05% (Encube Ethicals Private Limited), CLOBETASOL PROPIONATE CREAM USP, 0.05% (NuCare Pharmaceuticals), CLOBETASOL PROPIONATE CREAM, 0.05% (Proficient Rx LP), CLODAN (Medimetriks Pharmaceuticals), TOVET (EMOLLIENT FORMULATION) (Medimetriks Pharmaceuticals)
Formula
C25H32ClFO5
Exact mass
466.1922
Mol weight
466.97
Structure
Simcomp
Class
Anti-inflammatory
 DG01955  Corticosteroid
  DG02068  Glucocorticoid
Dermatological agent
 DG03243  Atopic dermatitis agent
Remark
Therapeutic category: 2646
ATC code: D07AD01
Chemical structure group: DG00422
Product (DG00422): D01272<JP/US>
Efficacy
Anti-inflammatory, Glucocorticoid receptor agonist
  Disease
Plaque psoriasis [DS:H01656]
Psoriasis [DS:H01656]
Target
NR3C1 (GR) [HSA:2908] [KO:K05771]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D07 CORTICOSTEROIDS, DERMATOLOGICAL PREPARATIONS
   D07A CORTICOSTEROIDS, PLAIN
    D07AD Corticosteroids, very potent (group IV)
     D07AD01 Clobetasol
      D01272  Clobetasol propionate (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
 Dermatological Agents
  Dermatitis and Pruitus Agents
   Glucocorticoids, Very High Potency
    Clobetasol
     D01272  Clobetasol propionate (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  26  Epidermides
   264  Analgesics, anti-itchings, astringents, anti-inflammatory agents
    2646  Adrenocorticotropic hormones
     D01272  Clobetasol propionate (JP18/USP)
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00422  Clobetasol
     D01272  Clobetasol propionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01272  Clobetasol propionate
Drug classes [BR:br08332]
 Anti-inflammatory
  DG01955  Corticosteroid
   D01272  Clobetasol propionate
 Dermatological agent
  DG03243  Atopic dermatitis agent
   D01272  Clobetasol propionate
Target-based classification of drugs [BR:br08310]
 Nuclear receptors
  Estrogen like receptors
   3-Ketosteroid receptor
    NR3C1 (GR)
     D01272  Clobetasol propionate (JP18/USP) <JP/US>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01272  Clobetasol propionate
Topical steroids potency [br08317.html]
 Classification in the USA
  D01272
 Classification in Japan
  D01272
Drug groups [BR:br08330]
 Anti-inflammatory
  DG01955  Corticosteroid
   DG02068  Glucocorticoid
    DG00422  Clobetasol
Other DBs
CAS: 25122-46-7
PubChem: 7848335
ChEBI: 31414
PDB-CCD: XRD[PDBj]
LigandBox: D01272
NIKKAJI: J21.005F
LinkDB
KCF data

ATOM        32
            1   C1z C    25.9683  -13.7546
            2   C1z C    24.8006  -14.4311
            3   C1y C    27.1363  -14.4367
            4   O7a O    27.1419  -13.0724
            5   C5a C    25.9567  -12.3961
            6   C1y C    24.8006  -15.7780
            7   C1x C    23.6327  -13.7489
            8   C1a C    24.7947  -13.0551
            9   C1x C    27.1304  -15.7839
            10  C7a C    29.0033  -13.0724
            11  C1b C    27.1479  -11.7080
            12  O5a O    24.7659  -11.7196
            13  C1y C    23.6270  -16.4545
            14  C1y C    22.4591  -14.4252
            15  X   Cl   27.1363  -10.3320
            16  C1z C    22.4534  -15.7780
            17  C1x C    23.6327  -17.8073
            18  O1a O    21.2798  -13.7373
            19  C1z C    21.2856  -16.4545
            20  X   F    22.4476  -17.1252
            21  C1x C    22.4591  -18.4896
            22  C2y C    21.2856  -17.8131
            23  C2x C    20.1120  -15.7780
            24  C1a C    21.2740  -15.1016
            25  C2x C    20.1120  -18.4896
            26  C2x C    18.9383  -16.4545
            27  C5x C    18.9383  -17.8131
            28  O5x O    17.7590  -18.4836
            29  C1a C    28.5156  -14.4341
            30  O6a O    29.6949  -14.2703
            31  C1b C    29.6949  -11.8745
            32  C1a C    31.0780  -11.8745
BOND        35
            1     1   5 1 #Up
            2     2   6 1
            3     2   7 1
            4     2   8 1 #Up
            5     3   9 1
            6     4  10 1
            7     5  11 1
            8     5  12 2
            9     6  13 1
            10    7  14 1
            11   11  15 1
            12   13  16 1
            13   13  17 1
            14   14  18 1 #Up
            15   16  19 1
            16   16  20 1 #Down
            17   17  21 1
            18   19  22 1
            19   19  23 1
            20   19  24 1 #Up
            21   22  25 2
            22   23  26 2
            23   25  27 1
            24   27  28 2
            25    6   9 1
            26   14  16 1
            27   21  22 1
            28   26  27 1
            29    3  29 1 #Up
            30    1   2 1
            31   10  30 2
            32    1   3 1
            33   10  31 1
            34    1   4 1 #Down
            35   31  32 1

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