KEGG   DRUG: Ethyl loflazepateHelp
Entry
D01293                      Drug                                   

Name
Ethyl loflazepate (JAN/INN);
Meilax (TN)
Formula
C18H14ClFN2O3
Exact mass
360.0677
Mol weight
360.7668
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01567  GABA-A receptor agonist
 DG01914  Anxiolytics, benzodiazepine derivatives
Enzyme substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 1124
ATC code: N05BA18
Product: D01293<JP>
Efficacy
Antianxiety
Comment
Benzodiazepine derivative
Target
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
map07030  Anxiolytics
map07230  GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA18 Ethyl loflazepate
      D01293  Ethyl loflazepate (JAN/INN) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   112  Hypnotics and sedatives, anxiolytics
    1124  Benzodiazepins
     D01293  Ethyl loflazepate (JAN/INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Ligand-gated ion channels
   GABA (ionotropic)
    GABR
     D01293  Ethyl loflazepate (JAN/INN) <JP>
Drug classes of therapeutic agents [br08360.html]
 Psychiatric agents
  D01293
BRITE hierarchy
Other DBs
CAS: 29177-84-2
PubChem: 7848356
ChEBI: 31573
ChEMBL: CHEMBL1213460
DrugBank: DB01545
LigandBox: D01293
NIKKAJI: J21.650J
LinkDB All DBs
KCF data Show

ATOM        25
            1   C2y C    19.3834  -15.4794
            2   C8y C    18.5413  -14.3698
            3   C8y C    18.8765  -13.0130
            4   N1x N    20.1375  -12.4349
            5   N2x N    20.7892  -15.5046
            6   C5x C    21.3911  -13.0572
            7   C1y C    21.6776  -14.4259
            8   C8x C    17.8694  -12.0446
            9   C8x C    16.5274  -12.4327
            10  C8y C    16.1922  -13.7895
            11  C8x C    17.1993  -14.7576
            12  X   Cl   14.8274  -14.1839
            13  C8y C    18.7489  -16.7291
            14  C8x C    17.3473  -16.7291
            15  C8x C    16.6473  -17.9416
            16  C8x C    17.3473  -19.1540
            17  C8x C    18.7489  -19.1540
            18  C8y C    19.4489  -17.9416
            19  X   F    20.8598  -17.9417
            20  C7a C    22.8901  -15.1259
            21  O7a O    24.1025  -14.4259
            22  O5x O    22.5003  -12.1995
            23  O6a O    22.8901  -16.5200
            24  C1b C    25.2954  -15.1148
            25  C1a C    26.4865  -14.4271
BOND        27
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13   10  12 1
            14    1  13 1
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   13  18 2
            21   18  19 1
            22    7  20 1
            23   20  21 1
            24    6  22 2
            25   20  23 2
            26   21  24 1
            27   24  25 1

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