 | | DRUG: Hydralazine hydrochloride | |
| Entry |
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| Name |
Hydralazine hydrochloride (JP18/USP);
Apresoline (TN) |
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| Product |
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| Generic |
HYDRALAZINE (Nivagen Pharmaceuticals), HYDRALAZINE HCL (DirectRX), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (A-S Medication Solutions), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Health Packaging), HYDRALAZINE HYDROCHLORIDE (American Regent), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), HYDRALAZINE HYDROCHLORIDE (Ascend Laboratories), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Bryant Ranch Prepack), HYDRALAZINE HYDROCHLORIDE (Cadila Pharmaceuticals Limited), HYDRALAZINE HYDROCHLORIDE (Camber Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Cardinal Health 107), HYDRALAZINE HYDROCHLORIDE (Chartwell RX), HYDRALAZINE HYDROCHLORIDE (Civica), HYDRALAZINE HYDROCHLORIDE (Denton Pharma), HYDRALAZINE HYDROCHLORIDE (Direct_Rx), HYDRALAZINE HYDROCHLORIDE (Eugia US LLC), HYDRALAZINE HYDROCHLORIDE (Exelan Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Fresenius Kabi USA), HYDRALAZINE HYDROCHLORIDE (Glenmark Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDRALAZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDRALAZINE HYDROCHLORIDE (HF Acquisition Co LLC), HYDRALAZINE HYDROCHLORIDE (Henry Schein), HYDRALAZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Heritage Pharmaceuticals Inc. d/b/a Avet Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Hikma Pharmaceuticals USA), HYDRALAZINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), HYDRALAZINE HYDROCHLORIDE (Major Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDRALAZINE HYDROCHLORIDE (McKesson Corporation dba SKY Packaging), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Medical Purchasing Solutions), HYDRALAZINE HYDROCHLORIDE (Modavar Pharmaceuticals LLC), HYDRALAZINE HYDROCHLORIDE (Mylan Institutional), HYDRALAZINE HYDROCHLORIDE (NCS HealthCare of KY), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Northwind Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (NuCare Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (PD-Rx Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Preferred Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (Proficient Rx LP), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (REMEDYREPACK), HYDRALAZINE HYDROCHLORIDE (Radha Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (ScieGen Pharmaceuticals), HYDRALAZINE HYDROCHLORIDE (Strides Pharma Science Limited), HYDRALAZINE HYDROCHLORIDE (Teva Pharmaceuticals USA) |
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| Formula |
C8H8N4. HCl
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| Exact mass |
196.0516
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| Mol weight |
196.64
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| Structure |
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| Simcomp |
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| Class |
Cardiovascular agent
DG03231 Antihypertensive
DG02046 Hydrazinophthalazine derivative
Metabolizing enzyme substrate
DG02928 NAT substrate
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
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| Remark |
| Therapeutic category: | 2142 |
| Product (DG00261): | D01302<JP/US> |
| Product (mixture): | D10209<US> |
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| Efficacy |
Antihypertensive |
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| Disease |
Essential hypertension [DS: H01633] |
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| Comment |
Hydrazinophthalazine derivative
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| Metabolism |
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565]
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| Brite |
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
C CARDIOVASCULAR SYSTEM
C02 ANTIHYPERTENSIVES
C02D ARTERIOLAR SMOOTH MUSCLE, AGENTS ACTING ON
C02DB Hydrazinophthalazine derivatives
C02DB02 Hydralazine
D01302 Hydralazine hydrochloride (JP18/USP) <JP/US>
USP drug classification [BR:br08302]
Cardiovascular Agents
Vasodilators
Vasodilators, Direct-acting Arterial
Hydralazine
D01302 Hydralazine hydrochloride (JP18/USP)
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2142 Hydralazines
D01302 Hydralazine hydrochloride (JP18/USP)
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG00261 Hydralazine
D01302 Hydralazine hydrochloride
DG02046 Hydrazinophthalazine derivative
DG00261 Hydralazine
D01302 Hydralazine hydrochloride
Metabolizing enzyme substrate
DG02928 NAT substrate
DG00261 Hydralazine
D01302 Hydralazine hydrochloride
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00261 Hydralazine
D01302 Hydralazine hydrochloride
Drug classes [BR:br08332]
Cardiovascular agent
DG03231 Antihypertensive
D01302 Hydralazine hydrochloride
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01302 Hydralazine hydrochloride
D01302 Hydralazine hydrochloride tablets
D01302 Hydralazine hydrochloride powder
D01302 Hydralazine hydrochloride for injection
Drug metabolizing enzymes and transporters [br08309.html]
Drug metabolizing enzymes
D01302
Drug groups [BR:br08330]
Cardiovascular agent
DG03231 Antihypertensive
DG00261 Hydralazine
DG02046 Hydrazinophthalazine derivative
DG00261 Hydralazine
Metabolizing enzyme substrate
DG02928 NAT substrate
DG00261 Hydralazine
Metabolizing enzyme inhibitor
DG01645 CYP2D6 inhibitor
DG00261 Hydralazine
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| Other DBs |
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| LinkDB |
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| KCF data |
ATOM 13
1 C8x C 19.0523 -16.4104
2 C8x C 19.0523 -17.8110
3 C8x C 20.2682 -18.5113
4 C8x C 20.2682 -15.7101
5 C8y C 21.4769 -16.4104
6 C8y C 21.4710 -17.8110
7 C8x C 22.6809 -18.5163
8 N5x N 23.8968 -17.8213
9 N5x N 23.9027 -16.4208
10 C8y C 22.6928 -15.7154
11 N1b N 22.6987 -14.3148
12 N1a N 23.9148 -13.6196
13 X Cl 28.1844 -16.5518
BOND 13
1 1 2 2
2 2 3 1
3 3 6 2
4 5 4 2
5 5 6 1
6 6 7 1
7 7 8 2
8 8 9 1
9 9 10 2
10 10 5 1
11 4 1 1
12 10 11 1
13 11 12 1
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