KEGG   DRUG: Dihydrocodeine phosphateHelp
Entry
D01481                      Drug                                   

Name
Dihydrocodeine phosphate (JP17);
Dihydro (TN)
Formula
C18H23NO3. H3PO4
Exact mass
399.1447
Mol weight
399.3753
Structure
Mol fileKCF fileDB search
Simcomp SIMCOMP
Class
Neuropsychiatric agent
 DG01564  Opioid receptor agonist
  DG01563  mu-Opioid receptor agonist
Analgesic
 DG01984  Opioid analgesics
Enzyme substrate
 DG01644  CYP2D6 substrate
Remark
Therapeutic category: 2242 8115
ATC code: N02AA08
Chemical structure group: DG00814
Product (DG00814): D01481<JP>
Product (mixture): D04338<JP> D04313<JP> D08695<JP> D08697<JP>
Efficacy
Antitussive, Narcotic, Opioid receptor agonist
Comment
Opium alkaloid
Target
OPRM1 [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
Metabolism
Enzyme: UGT2B7 [HSA:7364], UGT2B4 [HSA:7363]; CYP3A4 [HSA:1576], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
map07224  Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AA Natural opium alkaloids
     N02AA08 Dihydrocodeine
      D01481  Dihydrocodeine phosphate (JP17) <JP>
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   224  Antitussives and expectorants
    2242  Codeines
     D01481  Dihydrocodeine phosphate (JP17)
 8  Narcotics
  81  Alkaloidal narcotics
   811  Opium alkaloids
    8115  Codeines
     D01481  Dihydrocodeine phosphate (JP17)
Classification of Japanese OTC drugs [BR:br08313]
 Agents for respiratory organs
  26 Antitussives and expectorants
   D01481  Dihydrocodeine phosphate (JP17)
Risk category of Japanese OTC drugs [BR:br08312]
 Designated second-class OTC drugs
  Inorganic and organic chemicals
   Dihydrocodeine
    D01481  Dihydrocodeine phosphate (JP17)
 Second-class OTC drugs
  Inorganic and organic chemicals
   Dihydrocodeine
    D01481  Dihydrocodeine phosphate (JP17)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    OPRM1
     D01481  Dihydrocodeine phosphate (JP17) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D01481  Dihydrocodeine phosphate
  D01481  1% dihydrocodeine phosphate powder
  D01481  10% dihydrocodeine phosphate powder
Drug classes of therapeutic agents [br08360.html]
 Anesthetics, analgesics and anti-inflammatory drugs
  D01481
BRITE hierarchy
Other DBs
CAS: 24204-13-5
PubChem: 7848544
ChEBI: 31489
DrugBank: DB01551
LigandBox: D01481
NIKKAJI: J264.706K
LinkDB All DBs
KCF data Show

ATOM        27
            1   C1z C     7.1291  -11.7332
            2   C8y C     7.1349  -10.4399
            3   C1y C     8.2478  -12.3917
            4   C1y C     6.0047  -12.3917
            5   C1x C     8.0556  -10.8244
            6   C8y C     6.0280   -9.7816
            7   C8y C     8.2653   -9.8049
            8   C1y C     9.3839  -11.7507
            9   C1x C     8.2536  -13.6910
            10  O2x O     4.7521  -11.0749
            11  C1y C     6.0047  -13.6910
            12  C1x C    10.4850  -10.8127
            13  C8y C     6.0337   -8.4881
            14  C1x C     9.3897  -10.4516
            15  C8x C     8.2768   -8.5112
            16  N1y N    10.5084  -12.4091
            17  C1x C     7.1291  -14.3376
            18  C8x C     7.1641   -7.8471
            19  O2a O     4.9151   -7.8298
            20  O1a O     4.8799  -14.3415
            21  C1a C     3.7063   -8.5145
            22  C1a C    11.9044  -12.4091
            23  P1b P    16.2129  -11.4022
            24  O1c O    17.5248  -11.4141
            25  O1c O    14.9839  -11.4141
            26  O1c O    16.2720  -12.8330
            27  O1c O    16.2482   -9.7756
BOND        30
            1     4  10 1 #Down
            2     4  11 1
            3     5  12 1
            4     6  13 2
            5     7  14 1
            6     7  15 1
            7     8  16 1 #Up
            8     9  17 1
            9    13  18 1
            10   13  19 1
            11    6  10 1
            12    8  14 1
            13   11  17 1
            14   12  16 1
            15   15  18 2
            16   11  20 1 #Down
            17    1   2 1
            18    1   3 1
            19    1   4 1
            20    1   5 1 #Up
            21    2   6 1
            22    2   7 2
            23    3   8 1
            24    3   9 1
            25   19  21 1
            26   16  22 1
            27   23  24 1
            28   23  25 1
            29   23  26 1
            30   23  27 2

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