Entry |
|
Name |
Efonidipine hydrochloride ethanolate (JAN); Efonidipine hydrochloride ethanol; Efonidipine hydrochloride; NZ 105 ethanolate; Landel (TN) |
Formula |
C34H38N3O7P. C2H6O. HCl
|
Exact mass |
713.2633
|
Mol weight |
714.18
|
Structure |
|
Simcomp |
|
Class |
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01573 Calcium channel T type blocker
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
|
Remark |
Therapeutic category: | 2149 |
Product (DG01382): | D01604<JP> |
|
Efficacy |
Antihypertensive, Vasodilator, Calcium channel blocker |
Comment |
Dihydropyridine derivative
|
Target |
|
Pathway |
hsa04261 | Adrenergic signaling in cardiomyocytes |
hsa04270 | Vascular smooth muscle contraction |
|
Interaction |
|
Structure map |
|
Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
21 Cardiovascular agents
214 Antihypertensives
2149 Others
D01604 Efonidipine hydrochloride ethanolate (JAN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01382 Efonidipine
D01604 Efonidipine hydrochloride ethanolate
DG01573 Calcium channel T type blocker
DG01382 Efonidipine
D01604 Efonidipine hydrochloride ethanolate
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG01382 Efonidipine
D01604 Efonidipine hydrochloride ethanolate
Drug classes [BR:br08332]
Cardiovascular agent
DG01928 Dihydropyridine calcium channel blocker
D01604 Efonidipine hydrochloride ethanolate
DG03231 Antihypertensive
D01604 Efonidipine hydrochloride ethanolate
Target-based classification of drugs [BR:br08310]
Ion channels
Voltage-gated ion channels
Calcium channels
CACNA1-L
D01604 Efonidipine hydrochloride ethanolate (JAN) <JP>
Drug groups [BR:br08330]
Cardiovascular agent
DG01575 Calcium channel blocker
DG01496 Calcium channel L type blocker
DG01382 Efonidipine
DG01573 Calcium channel T type blocker
DG01382 Efonidipine
DG03231 Antihypertensive
DG01928 Dihydropyridine calcium channel blocker
DG01382 Efonidipine
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 49
1 X Cl 33.4838 -19.3127
2 C1y C 27.1641 -14.0463
3 C2y C 28.3578 -13.3441
4 C2y C 25.9002 -13.3441
5 C8y C 27.1641 -15.4507
6 C2y C 28.3578 -11.9398
7 C7a C 29.5515 -14.0463
8 C2y C 25.9002 -11.9398
9 P1b P 24.7064 -14.0463
10 C8x C 28.3578 -16.1529
11 C8x C 25.9002 -16.1529
12 N1x N 27.1641 -11.2376
13 C1a C 29.5515 -11.1674
14 O7a O 30.7452 -13.3441
15 O6a O 29.5515 -15.4507
16 C1a C 24.7064 -11.2376
17 C8y C 28.3578 -17.5573
18 C8x C 25.9002 -17.5573
19 C1b C 32.0092 -14.0463
20 C8x C 27.1641 -18.2594
21 N2b N 29.5515 -18.2594 #+
22 C1b C 33.2029 -13.2739
23 O3a O 30.9555 -17.4173
24 O3a O 29.5515 -19.6638 #-
25 O2x O 24.7064 -15.4507
26 C1x C 23.4425 -16.1529
27 C1z C 22.2488 -15.4507
28 C1x C 22.2488 -14.0463
29 O2x O 23.5127 -13.3441
30 O3b O 24.7064 -12.6420
31 N1c N 34.3966 -13.9761
32 C1b C 35.6605 -13.3441
33 C8y C 36.8543 -13.9761
34 C8x C 38.0480 -13.3441
35 C8x C 39.2417 -14.0463
36 C8x C 39.2417 -15.3805
37 C8x C 38.0480 -16.0827
38 C8x C 36.8543 -15.3805
39 C8y C 34.3968 -15.3805
40 C8x C 35.5905 -16.0827
41 C8x C 35.5905 -17.4870
42 C8x C 34.3968 -18.1892
43 C8x C 33.2031 -17.4870
44 C8x C 33.2031 -16.0827
45 C1a C 21.0338 -16.1456
46 C1a C 21.0545 -14.7581
47 C1a C 39.1012 -19.3127
48 C1b C 37.9075 -18.6105
49 O1a O 36.6436 -19.3127
BOND 51
1 21 23 2
2 21 24 1
3 8 12 1
4 18 20 2
5 2 3 1
6 2 4 1
7 2 5 1
8 9 25 1
9 25 26 1
10 26 27 1
11 27 28 1
12 28 29 1
13 29 9 1
14 3 6 2
15 9 30 2
16 3 7 1
17 4 8 2
18 4 9 1
19 22 31 1
20 5 10 1
21 31 32 1
22 5 11 2
23 32 33 1
24 6 12 1
25 6 13 1
26 7 14 1
27 7 15 2
28 8 16 1
29 33 34 2
30 34 35 1
31 35 36 2
32 36 37 1
33 37 38 2
34 38 33 1
35 10 17 2
36 31 39 1
37 11 18 1
38 14 19 1
39 17 20 1
40 17 21 1
41 19 22 1
42 39 40 2
43 40 41 1
44 41 42 2
45 42 43 1
46 43 44 2
47 44 39 1
48 27 45 1
49 27 46 1
50 47 48 1
51 48 49 1
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