KEGG ORTHOLOGY: K04850

ORTHOLOGY: K04850

Entry

K04850                      KO

Symbol

CACNA1C, CAV1.2

Name

voltage-dependent calcium channel L type alpha-1C

Pathway

map04010

MAPK signaling pathway

map04020

Calcium signaling pathway

map04022

cGMP-PKG signaling pathway

map04024

cAMP signaling pathway

map04260

Cardiac muscle contraction

map04261

Adrenergic signaling in cardiomyocytes

map04270

Vascular smooth muscle contraction

map04713

Circadian entrainment

map04720

Long-term potentiation

map04723

Retrograde endocannabinoid signaling

map04724

Glutamatergic synapse

map04725

Cholinergic synapse

map04726

Serotonergic synapse

map04727

GABAergic synapse

map04728

Dopaminergic synapse

map04742

Taste transduction

map04911

Insulin secretion

map04912

GnRH signaling pathway

map04921

Oxytocin signaling pathway

map04924

Renin secretion

map04925

Aldosterone synthesis and secretion

map04927

Cortisol synthesis and secretion

map04929

GnRH secretion

map04930

Type II diabetes mellitus

map04934

Cushing syndrome

map04935

Growth hormone synthesis, secretion and action

map05010

Alzheimer disease

map05020

Prion disease

map05022

Pathways of neurodegeneration - multiple diseases

map05031

Amphetamine addiction

map05207

Chemical carcinogenesis - receptor activation

map05410

Hypertrophic cardiomyopathy

map05412

Arrhythmogenic right ventricular cardiomyopathy

map05414

Dilated cardiomyopathy

Disease

H00720

Long QT syndrome

H00728

Brugada syndrome

H02397

Neurodevelopmental disorder with movement abnormalities or hypotonia

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04020 Calcium signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04024 cAMP signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04022 cGMP-PKG signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04929 GnRH secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04912 GnRH signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04921 Oxytocin signaling pathway
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04935 Growth hormone synthesis, secretion and action
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04924 Renin secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04925 Aldosterone synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04927 Cortisol synthesis and secretion
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04261 Adrenergic signaling in cardiomyocytes
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04270 Vascular smooth muscle contraction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09156 Nervous system
   04724 Glutamatergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04727 GABAergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04725 Cholinergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04728 Dopaminergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04726 Serotonergic synapse
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04720 Long-term potentiation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04723 Retrograde endocannabinoid signaling
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09157 Sensory system
   04742 Taste transduction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09159 Environmental adaptation
   04713 Circadian entrainment
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09160 Human Diseases
  09161 Cancer: overview
   05207 Chemical carcinogenesis - receptor activation
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05020 Prion disease
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05022 Pathways of neurodegeneration - multiple diseases
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09165 Substance dependence
   05031 Amphetamine addiction
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   05414 Dilated cardiomyopathy
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
   04934 Cushing syndrome
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04040 Ion channels
    K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C
Ion channels [BR:ko04040]
Voltage-gated cation channels
  Calcium channel, voltage-gated (Cav)
   K04850  CACNA1C, CAV1.2; voltage-dependent calcium channel L type alpha-1C

Other DBs

GO:

0005245

TC:	1.A.1.11.4 1.A.1.11.6

Genes

HSA:	775(CACNA1C)

PTR:	466915(CACNA1C)

PPS:	100971701(CACNA1C)

GGO:	101134060(CACNA1C)

PON:	100442085(CACNA1C)

PPYG:

129009980

NLE:	100580437(CACNA1C)

HMH:	116472525(CACNA1C)

SSYN:

129483539

MCC:	721721(CACNA1C)

MCF:	101865175(CACNA1C)

MTHB:

126930225

MNI:	105484109(CACNA1C)

CSAB:

103218385(CACNA1C)

CATY:

105582968(CACNA1C)

PANU:

101026237(CACNA1C)

TGE:	112634000(CACNA1C)

MLEU:

105529889(CACNA1C)

RRO:	104659017(CACNA1C)

RBB:	108522695(CACNA1C)

TFN:

117090701

PTEH:

111520328(CACNA1C)

CANG:

105503912(CACNA1C)

CJC:	100406735(CACNA1C)

SBQ:	101040048(CACNA1C)

CIMI:

108315880(CACNA1C)

ANAN:

105733730(CACNA1C)

CSYR:

103259018(CACNA1C)

MMUR:

105861596(CACNA1C)

LCAT:

123640189(CACNA1C)

PCOQ:

105815791(CACNA1C)

OGA:	100964267(CACNA1C)

MMU:	12288(Cacna1c)

MCAL:

110295755

MPAH:

110317086(Cacna1c)

RNO:	24239(Cacna1c)

MCOC:

116099482(Cacna1c)

ANU:	117715086(Cacna1c)

MUN:	110541273(Cacna1c)

CGE:	100754788(Cacna1c)

MAUA:

101834428(Cacna1c)

PROB:

127236163(Cacna1c)

PLEU:

114700762(Cacna1c)

MORG:

121441414(Cacna1c)

MFOT:

126505446

AAMP:

119806908(Cacna1c)

NGI:	103739378(Cacna1c)

HGL:	101717129(Cacna1c)

CPOC:

100135490(Cacna1c)

DORD:

105991064(Cacna1c)

PLOP:

125342716(Cacna1c)

NCAR:

124982084

MMMA:

107154890(Cacna1c)

OCU:	100101555(CACNA1C)

OPI:	101536063(CACNA1C)

GVR:	103595029(CACNA1C)

CFA:	403516(CACNA1C)

CLUD:

112668971(CACNA1C)

VVP:	112917426(CACNA1C)

VLG:	121479835(CACNA1C)

NPO:	129503382(CACNA1C)

AML:	100479715(CACNA1C)

UMR:	103675706(CACNA1C)

UAH:	113258052(CACNA1C)

UAR:	123777895(CACNA1C)

ELK:

111159674

LLV:

125107204

MPUF:

101679746(CACNA1C)

MNP:	132019988(CACNA1C)

MLK:	131838359(CACNA1C)

NVS:	122892214(CACNA1C)

ORO:	101365624(CACNA1C)

EJU:	114222521(CACNA1C)

ZCA:	113921757(CACNA1C)

MLX:	118025809(CACNA1C)

NSU:	110581023(CACNA1C)

FCA:	101082923(CACNA1C)

PYU:	121022112(CACNA1C)

PCOO:

112867221(CACNA1C)

PBG:	122473119(CACNA1C)

PVIV:

125170417(CACNA1C)

LRUF:

124501399

PTG:	102956322(CACNA1C)

PPAD:

109276255(CACNA1C)

PUC:

125920056

AJU:

106965473

HHV:	120243774(CACNA1C)

BTA:	408015(CACNA1C)

BOM:	102277590(CACNA1C)

BIU:	109558615(CACNA1C)

BBUB:

102407190(CACNA1C)

BBIS:

104992358(CACNA1C)

CHX:	100861292(CACNA1C)

OAS:	101116562(CACNA1C)

BTAX:

128048945(CACNA1C)

ODA:	120857839(CACNA1C)

CCAD:

122424089(CACNA1C)

MBEZ:

129535727(CACNA1C)

SSC:	100518733(CACNA1C)

CFR:	102524149(CACNA1C)

CBAI:

105076642(CACNA1C)

CDK:	105100748(CACNA1C)

VPC:	102538871(CACNA1C)

BACU:

103019389(CACNA1C)

BMUS:

118901684(CACNA1C)

LVE:	103087340(CACNA1C)

OOR:	101272740(CACNA1C)

DLE:	111176594(CACNA1C)

PCAD:

102989784(CACNA1C)

PSIU:

116760103(CACNA1C)

NASI:

112391637(CACNA1C)

ECB:	100049924(CACNA1C)

EAI:	106839455(CACNA1C)

MYB:	102240225(CACNA1C)

MYD:	102753812(CACNA1C)

MMYO:

118652154(CACNA1C)

MLF:	102424719(CACNA1C)

MDT:	132228098(CACNA1C)

PKL:	118730029(CACNA1C)

EFUS:

103296724(CACNA1C)

MNA:	107546425(CACNA1C)

DRO:	112309331(CACNA1C)

SHON:

118999983(CACNA1C)

AJM:	119051688(CACNA1C)

PDIC:

114512949(CACNA1C)

PHAS:

123813423(CACNA1C)

MMF:	118624255(CACNA1C)

PPAM:

129073529(CACNA1C)

HAI:	109388950(CACNA1C)

RFQ:	117029264(CACNA1C)

PALE:

102882682(CACNA1C)

PGIG:

120607351(CACNA1C)

PVP:	105297298(CACNA1C)

RAY:	107500540(CACNA1C)

MJV:	108387253(CACNA1C)

TOD:	119247058(CACNA1C)

SARA:

101557862(CACNA1C)

SETR:

126022196(CACNA1C)

TMU:

101360945

ETF:	101656925(CACNA1C)

DNM:	101431301(CACNA1C)

MDO:	100021421(CACNA1C)

GAS:	123250056(CACNA1C)

SHR:

100926503

AFZ:

127564847

PCW:	110218748(CACNA1C)

TVP:	118849734(CACNA1C)

OAA:	100082618(CACNA1C)

GGA:	395891(CACNA1C)

PCOC:

116226870(CACNA1C)

MGP:	100547459 104911865

CJO:	107315213(CACNA1C)

TPAI:

128073122(CACNA1C)

LMUT:

125693421(CACNA1C)

NMEL:

110395457(CACNA1C)

APLA:

101790062(CACNA1C)

ACYG:

106030933(CACNA1C)

CATA:

118250054(CACNA1C)

AFUL:

116489537(CACNA1C)

TGU:	100218244(CACNA1C)

LSR:	110472925(CACNA1C)

SCAN:

103820462(CACNA1C)

PMOA:

120501729(CACNA1C)

OTC:	121332892(CACNA1C)

PRUF:

121362733(CACNA1C)

GFR:

102031898

FAB:	101815051(CACNA1C)

OMA:	130263585(CACNA1C)

PHI:	102106069(CACNA1C)

PMAJ:

107204397(CACNA1C)

CCAE:

111928486

CCW:	104692245(CACNA1C)

CBRC:

103624725(CACNA1C)

ETL:	114069083(CACNA1C)

ZAB:	102070167(CACNA1C)

ZLE:	135459658(CACNA1C)

ACHL:

103806638(CACNA1C)

SVG:	106849354(CACNA1C)

MMEA:

130588985(CACNA1C)

HRT:	120751816(CACNA1C)

SATI:

136361465(CACNA1C)

FPG:	101916694(CACNA1C)

FCH:	102048150(CACNA1C)

NNT:

104410749

SHAB:

115605742(CACNA1C)

ACUN:

113475961(CACNA1C)

TALA:

104361153(CACNA1C)

ACHC:

115352314(CACNA1C)

HALD:

104325178

HLE:	104830930(CACNA1C)

AGEN:

126047933

GCL:

127013811

CSTI:

104563363

LDI:	104353406(CACNA1C)

MNB:	103768936(CACNA1C)

DPUB:

104299582(CACNA1C)

AVIT:

104278438(CACNA1C)

EGZ:	104134399(CACNA1C)

NNI:	104020209(CACNA1C)

PADL:

103924366(CACNA1C)

AFOR:

103898648(CACNA1C)

FGA:

104072796

CLV:	102095010(CACNA1C)

MUI:

PGUU:

PLET:

EHS:

CMAC:

104487032(CACNA1C)

CUCA:

104055901(CACNA1C)

OHA:	104330270(CACNA1C)

CPEA:

104386585(CACNA1C)

CVF:	104281606(CACNA1C)

RTD:	128909658(CACNA1C)

AAM:	106488364(CACNA1C)

AROW:

112968301(CACNA1C)

DNE:	112993380(CACNA1C)

SCAM:

104147270(CACNA1C)

ASN:	102377475(CACNA1C)

AMJ:	102575519(CACNA1C)

CPOO:

109316457(CACNA1C)

GGN:	109296233(CACNA1C)

PSS:	102451554(CACNA1C)

CMY:	102940198(CACNA1C)

CCAY:

125625969(CACNA1C)

DCC:	119848353(CACNA1C)

CPIC:

101946823(CACNA1C)

TST:	117882551(CACNA1C)

CABI:

116834346

MRV:	120408934(CACNA1C)

ACS:	100553244(cacna1c)

ASAO:

132775772(CACNA1C)

PVT:	110076659(CACNA1C)

SUND:

121932087(CACNA1C)

PMUR:

107288329(CACNA1C)

CTIG:

120315478(CACNA1C)

PGUT:

117655788(CACNA1C)

APRI:

131202696(CACNA1C)

PTEX:

113447447(CACNA1C)

NSS:	113419359(CACNA1C)

VKO:	123016508(CACNA1C)

PMUA:

114605885

PRAF:

128422166(CACNA1C)

ZVI:	118090932(CACNA1C)

HCG:	128326984(CACNA1C)

GJA:	107120231(CACNA1C)

STOW:

125434341(CACNA1C)

EMC:	129335461(CACNA1C)

XLA:	100462911(cacna1c.S) 108704565(cacna1c.L)

XTR:	100488055(cacna1c)

NPR:

108791575

RTEM:

120932711(CACNA1C)

BBUF:

121004433(CACNA1C)

BGAR:

122928487(CACNA1C)

MUO:	115477346(CACNA1C)

GSH:	117363429(CACNA1C)

DRE:	170581(cacna1c)

SRX:

107732972

SANH:

107694143

SGH:	107589041 107590584

CCAR:

109104295

CAUA:

113048094 113062313

CGIB:

127956189 127973732

PTET:

122342654(cacna1c)

LROH:

127164112(cacna1c)

OMC:	131538945(cacna1c)

PPRM:

120476944(cacna1c)

RKG:	130072307(cacna1c)

MAMB:

125245652(cacna1c)

CIDE:

127511476

CERY:

137024507(cacna1c)

MASI:

127435437 127436755

TROS:

130547673(cacna1c)

TDW:	130420342(cacna1c)

MANU:

129431773(cacna1c)

IPU:	108279829(cacna1c)

IFU:	128622995(cacna1c)

PHYP:

113544629

SMEO:

124401221(cacna1c)

TFD:	113663733(cacna1c)

TVC:	132858817(cacna1c)

TRN:	134312571(cacna1c)

AMEX:

103041474(cacna1c)

CMAO:

118812645(cacna1c)

EEE:

113576556

CHAR:

105911367(cacna1c)

TRU:	101064574(cacna1c)

TFS:	130519478(cacna1c)

LCO:

104940547

TBEN:

117484877(cacna1c)

CGOB:

115028206(cacna1c)

PGEO:

117468450(cacna1c)

GACU:

117536109(cacna1c)

EMAC:

134879379(cacna1c)

ELY:	117249155(cacna1c)

EFO:	125883250(cacna1c)

PLEP:

121961140

SLUC:

116059999(cacna1c)

ECRA:

117938808(cacna1c)

ESP:

116672836

PFLV:

114549894

GAT:	120818340(cacna1c)

PPUG:

119210128(cacna1c)

AFB:	129112503(cacna1c)

CLUM:

117726173(cacna1c)

PSWI:

130200799(cacna1c)

MSAM:

119918210(cacna1c)

SCHU:

122871614(cacna1c)

CUD:	121505730(cacna1c)

ALAT:

119032303(cacna1c)

MZE:	101471946(cacna1c)

ONL:	100711294(cacna1c)

OAU:	116309817(cacna1c)

OLA:

101173517

OML:	112156742(cacna1c)

CSAI:

133424498(cacna1c)

XMA:	102230290(cacna1c)

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122826690(cacna1c)

PPRL:

129375629(cacna1c)

CVG:

107095494

CTUL:

119786207(cacna1c)

GMU:	124882886(cacna1c)

NFU:	107385235(cacna1c)

KMR:	108235074(cacna1c)

ALIM:

106515158

NWH:	119428184(cacna1c)

AOCE:

111571438

MCEP:

124999862(cacna1c)

CSEM:

103382787(cacna1c)

POV:

109632862

SSEN:

122767001(cacna1c)

HHIP:

117757229(cacna1c)

HSP:	118101730(cacna1c)

PPLT:

128428423(cacna1c)

SMAU:

118292530(cacna1c)

LCF:	108879625(cacna1c)

SDU:	111224579(cacna1c)

SLAL:

111658797(cacna1c)

XGL:	120800940(cacna1c)

HCQ:

109520063

SSCV:

125992468

SBIA:

133493429(cacna1c)

PEE:	133397145(cacna1c)

PTAO:

133471941(cacna1c)

BPEC:

110162494

MALB:

109959866

BSPL:

114862070(cacna1c)

SJO:	128353427(cacna1c)

OTW:

112240960

OMY:	110518351 110518394

OGO:	123995860 124020959 124024504

OKI:

109882530

OKE:	127925063(cacna1c)

SNH:	120032122(cacna1c)

CCLU:

121553635(cacna1c)

ELS:	105023097(cacna1c)

SFM:	108920904(cacna1c)

PKI:	111843125(cacna1c)

AANG:

118231977(cacna1c)

LOC:	102684408(cacna1c)

PSPA:

121318589 121319532

ARUT:

117415426 117419745

PSEX:

120540046

LCM:	102357941(CACNA1C)

CMK:	103179419(cacna1c)

RTP:

109920177

CPLA:

122559424(cacna1c)

HOC:	132824959(cacna1c)

LERI:

129706126(cacna1c)

PMRN:

116942266

LRJ:	133349342 133356809

SCLV:

TPAL:

LPOL:

PMEO:

PVUL:

BGT:

CRG:

CANU:

CVN:

MCAF:

MMER:

DPOL:

XEN:

HSY:

Reference

PMID:17071743

Authors

Tiwari S, Zhang Y, Heller J, Abernethy DR, Soldatov NM

Title

Atherosclerosis-related molecular alteration of the human CaV1.2 calcium channel alpha1C subunit.

Journal

Proc Natl Acad Sci U S A 103:17024-9 (2006)
DOI:10.1073/pnas.0606539103

Sequence

[hsa:775]

Reference

PMID:1316612

Authors

Soldatov NM

Title

Molecular diversity of L-type Ca2+ channel transcripts in human fibroblasts.

Journal

Proc Natl Acad Sci U S A 89:4628-32 (1992)
DOI:10.1073/pnas.89.10.4628

Sequence

[hsa:775]

LinkDB

DBGET integrated database retrieval system