Entry |
|
Name |
Naftopidil (JP18/INN); Flivas (TN) |
Formula |
C24H28N2O3
|
Exact mass |
392.2100
|
Mol weight |
392.49
|
Structure |
|
Class |
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
|
Remark |
Therapeutic category: | 2590 |
|
Efficacy |
Antidysuria, alpha1-Adrenergic receptor antagonist |
Target |
|
Pathway |
hsa04080 | Neuroactive ligand-receptor interaction |
hsa04270 | Vascular smooth muscle contraction |
|
Interaction |
|
Structure map |
map07215 | alpha-Adrenergic receptor agonists/antagonists |
|
Brite |
Therapeutic category of drugs in Japan [BR:br08301]
2 Agents affecting individual organs
25 Urogenital and anal organ agents
259 Miscellaneous
2590 Miscellaneous
D01674 Naftopidil (JP18/INN)
Drug groups [BR:br08330]
Cardiovascular agent
DG01466 Adrenergic receptor antagonist
DG01465 alpha-Adrenergic receptor antagonist
DG01457 alpha1-Adrenergic receptor antagonist
D01674 Naftopidil
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Adrenaline
ADRA1
D01674 Naftopidil (JP18/INN) <JP>
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
Chemicals
D01674 Naftopidil
D01674 Naftopidil tablets
D01674 Naftopidil orally disintegrating tablets
|
Other DBs |
|
LinkDB |
|
KCF data |
ATOM 29
1 N1y N 20.8567 -17.7071
2 C1x C 20.8567 -16.3024
3 C1x C 22.0762 -15.6000
4 N1y N 23.2885 -16.3024
5 C1x C 23.2885 -17.7071
6 C1x C 22.0762 -18.4095
7 C1b C 24.4963 -15.6072
8 C1c C 25.7094 -16.3096
9 C1b C 26.9226 -15.6142
10 O2a O 28.1358 -16.3165
11 C8y C 29.3490 -15.6213
12 O1a O 25.7064 -17.7143
13 C8x C 29.3534 -14.2231
14 C8x C 30.5666 -13.5279
15 C8x C 31.7753 -14.2307
16 C8y C 30.5575 -16.3244
17 C8y C 31.7632 -15.6300
18 C8x C 32.9674 -16.3271
19 C8x C 32.9657 -17.7184
20 C8x C 31.7601 -18.4126
21 C8x C 30.5560 -17.7157
22 C8y C 19.6405 -18.4102
23 C8x C 19.6458 -19.8078
24 C8x C 18.4295 -20.5108
25 C8x C 17.2126 -19.8090
26 C8x C 17.2119 -18.4042
27 C8y C 18.4282 -17.7014
28 O2a O 18.4316 -16.2966
29 C1a C 17.2108 -15.5876
BOND 32
1 13 14 1
2 14 15 2
3 15 17 1
4 16 11 1
5 1 2 1
6 7 8 1
7 2 3 1
8 8 9 1
9 3 4 1
10 9 10 1
11 16 17 1
12 17 18 2
13 18 19 1
14 19 20 2
15 20 21 1
16 21 16 2
17 4 5 1
18 1 22 1
19 10 11 1
20 5 6 1
21 8 12 1
22 6 1 1
23 22 23 2
24 23 24 1
25 24 25 2
26 25 26 1
27 26 27 2
28 27 22 1
29 4 7 1
30 27 28 1
31 11 13 2
32 28 29 1
|